[PDF] Top 20 The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double blind, double dummy, parallel group study

... occurred after 6 weeks of treatment. Analysis of non- inferiority indicated that ER was non-inferior to IR in improving ADLs and motor function of PD patients. Both arms showed similar overall ... See full document

... in Chinese patients with early PD are consistent with those reported for Caucasian ...present study revealed that mental function assessed by the UPDRS I subscale, but not daily activities or motor ... See full document

... PR group, although the overall incidence of AEs was comparable between treatment ...known safety profile of the opioid analgesic class of drugs, and with those seen in previous Phase III trials of OXN PR in ... See full document

... this study was to assess the efficacy and safety of entacapone, a catechol-O- methyltransferase (COMT) inhibitor in Parkinson's disease (PD) patients with wearing-off ...PD ... See full document

... test efficacy is high. The recruitment of patients is a diffi- cult task in rare diseases because of the paucity of available patients who fulfill the selection criteria, the quite hetero- geneity of ... See full document

... These study data supported that XFC deserve further research as a poten- tial Chinese medicine compound preparation for RA ...domized, double-blind, double parallel controlled ... See full document

... greater efficacy and a better safety profile than the individual ...recent study that the combination tablet might be as effective as gabapentin in the treatment of painful diabetic neuropathy in ... See full document

... additional efficacy over that observed with 175 μ g ...longer-term safety and efficacy ...in patients with COPD who require or prefer a nebulized drug delivery ... See full document

... placebo-controlled, double-blind study conducted in Asian patients with schizophrenia supports the advantages of PP treatment in this population, and suggests that PP could be used as a ... See full document

... 30 patients diagnosed with RA for at least 3 months and with a Disease Activity Score for 28 joints (DAS28) ≥ ...experimental group or the placebo group, in a 1:1 ratio and will make four ... See full document

... 226 patients were randomized to intravenous secukinumab 10 mg/kg (baseline, weeks 2 and 4) followed by subcutaneous secukinumab 300 mg (IV-300 mg) or 150 mg (IV-150 mg) every 4 weeks, or matched ...placebo. ... See full document

... Keywords: Chinese, donepezil, galantamine, randomized controlled trial, Alzheimer’s disease Introduction Alzheimer’s disease is a progressive neurodegenerative disorder with a mean duration of ... See full document

... • In RECORD4, 10 mg once-daily ‘Xarelto’ was compared to the U.S.-approved regimen for enoxaparin of 30 mg injected twice-daily. ‘Xarelto’ demonstrated a 31.4% RRR in total VTE in patients undergoing TKR surgery ... See full document

... MAD study, the highest dose in this study was chosen as 800 ...present study was unable to identify a definitive dose of AZD3199 to carry forward to Phase III ...COPD patients a plateau of the ... See full document

... Continuous data were assessed using analysis of cova- riance (ANCOVA) models of pairwise comparisons and generally included terms for treatment and the baseline measurement value as a covariate. Type III sums of squares ... See full document

... Migraine is divided into acute episode and chronic remission period. Accordingly, the treatment is divided into abortive treatment and preventive treatment. The former intends to return the patient to full function ... See full document

... pulmonary disease, exacerbation, zabofloxacin, quinolone, EXACT-PRO, CAT Introduction Exacerbation of chronic obstructive pulmonary disease (COPD) is characterized by a worsening of respiratory ... See full document

... in patients suffering from ...diabetic patients was not predictive of reduction in HbA1c, the effect of pro- longed-release melatonin on HbA1c is probably not related to the improvement in sleep, but rather ... See full document

... mostly patients with knee OA with mild to moderate pain scores at baseline, which might have made it difficult to detect the benefits of combined ...our patients with knee OA were mainly ...our study ... See full document

... randomised, double-blind, placebo-controlled study, 62 subjects with non-insulin treated type 2 diabetes were randomised to five treatment arms; CBD (100 mg twice daily), THCV (5 mg twice daily), 1:1 ... See full document