[PDF] Top 20 Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
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Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
... of lymphocytes from monocytes and ...for lymphocytes using elutriation for manufac- turing 8 CD19- and 5 GD2-CAR T cell ...+ cells and reduced proportions of CD14 + and CD15 + ...CAR T ... See full document
8
Chimeric antigen receptor T cells: a novel therapy for solid tumors
... membrane antigen; RCC: Renal cell carcinoma; RFS: Recurrence-free survival; scFv: Single-chain variable fragment; SCID: Severe combined immune deficiency; SD: Stable disease; TAAs: Tumor-associated antigens; ... See full document
13
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
... of cells in the presence of ...drives T cell dif- ferentiation and results in the loss of in vivo antitumor effi- cacy, new strategies for handling cultured T cells have been developing ... See full document
7
Chimeric antigen receptor T cell therapy for multiple myeloma
... cancer-specific antigen epitopes formed by post-translational events, such as glycosylation, complex formation, or conformational changes, might have been missed in previous ...CAR T cells against ... See full document
5
Chimeric Antigen Receptor T Cell Research For Clinical Applications
... CAR T cells through automation The dissemination of CAR T cell therapies to a wider number of patients is still hampered by the complexity of the manufacturing process requiring both ... See full document
139
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
... tumor-infiltrating lymphocytes is a predictor of favorable patient prognosis for many indications and is a requirement for responsiveness to immune checkpoint blockade therapy targeting programmed cell death ... See full document
19
Clinical and immunological responses after CD30 specific chimeric antigen receptor–redirected lymphocytes
... tion, T cells were expanded ex vivo in the presence of IL-2 (100 U/ml) or IL-7 (10 ng/ml) and IL-15 (5 ng/ml), added twice a ...the T cell products are sum- marized in Figure 2 and Supplemental Table ... See full document
11
Preclinical safety evaluation of chimeric antigen receptor modified T cells against CD19 in NSG mice
... Raji cells in the mice was effectively ...CART cells per animal, which was equivalent to 9-fold human therapeutic use dosage, and the main toxicological targets were the liver, lungs, spleen, brain, heart, ... See full document
18
CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
... Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric anti- gen receptors (CARs) are designed to benefit patients with ...CAR-redirected T ... See full document
6
Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia
... immunity, T lymphocytes satisfy all the above characteristics, and thus are most widely used as effector cells for CAR technology ...CAR-T cells specifically recognize tumor cell ... See full document
7
Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS prodigy system
... of cells for therapeutic doses, with a minimal starting cell ...CAR T cells presented lower immune suppression, higher activation status, differentiation toward Th1, Tc1 and T EM , and no ... See full document
14
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
... of T lymphocytes to target and treat cancer is a field that has been evolving over the past 25 ...bulk T cells from peripheral blood or tumor infil- trates, expansion ex vivo in the presence ... See full document
14
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... two chimeric antigen receptor-modified T cell types by the US Food and Drug Administration (FDA) for the treatment of hematologic malignancies is a milestone in immunotherapy; however, the ... See full document
10
T cells expressing chimeric antigen receptor promote immune tolerance
... target cells justifies use of stably transduced CAR T ...in antigen-specific peripheral tolerance, as MHC-matched second- ary skin grafts were accepted, while “third-party” grafts were ...induces ... See full document
18
Alloantigen specific regulatory T cells generated with a chimeric antigen receptor
... transplant-relevant antigen using a CAR. Expression of an A2-CAR in Tregs enables antigen-specific activation and pro- liferation that is stronger than that stimulated by the endogenous ...therapeutic ... See full document
13
Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
... CAR T cells against solid cancers, including mesothelioma, lung cancer, breast cancer, and pancreas cancer ...CAR T cells to treat GC remains to be ...and cells and then characterized ... See full document
14
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
... CAR T cells, we generated two versions of CARs, with or without a hinge domain, targeting CD19, mesothelin, PSCA (prostate stem cell antigen), MUC1, and HER2 (human epidermal growth factor ... See full document
11
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
... CAR-T cells with a new CAR architecture that is directly dimerized at the hinge domain with addition of the specific molecule ...conventional T cells into smart T cells whose ... See full document
11
Novel toxicology challenges in the era of chimeric antigen receptor T-cells therapies
... CAR T-cells based therapeutic clinical trials are increasingly performed worldwide with high expectations from scientists, clinicians and patients ...targeted antigen, but especially, in regard to ... See full document
6
Interleukin 12-Secreting Chimeric Antigen Receptor T Cells And Cancer Immunotherapy
... CAR T cell ...CAR T cell therapy also induces neurological abnormalities characterized by seizures, aphasia, and ...CAR T cell function and, on the other hand, also induces fever, hypotension, and ... See full document
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