[PDF] Top 20 Epithelial hypoxia inducible factor 1 is protective in murine experimental colitis

... of colitis in models other than TNBS might be different between WT and conditional Hif1a mutant ...oxazolone-induced colitis (30), a hapten-based model with a more Th2-type phenotype analogous to human ... See full document

... HIF- 1 α may also exert catabolic effects – for example, by inducing the cytokines IL-1 β and ...compensatory protective role or trigger the disease ... See full document

... caspase- 1 deficiency to a reduction in intestinal IL-18 activity (14–16), which supports our findings and implicates the noncanonical inflammasome in DSS-mediated intestinal ...DSS colitis, highlighting ... See full document

... All experimental procedu- res conformed to the Guide for the Care and Use of Laboratory Animals by the National Ins- titutes of Health (NIH) and were approved by the Animal Care and Use Committee of Pingjin ... See full document

... To investigate whether the aforementioned results were evi- dent in vivo, we used an FTC133 orthotopic xenograft mouse model generated by injection of shHIF-1α cells or LVcontrol cells into the thyroid gland. All mice ... See full document

... a murine model, HIF expression is only sustained for a few hours in a hypoxic environment, implying that factors other than hypoxia are necessary for sustained elevation of HIF levels ...reduce ... See full document

... protein 1 and hypoxia-inducible factor-1α (HIF-1α) (see ...in murine pristane-induced arthritis ...other experimental autoimmune conditions suggest that polymorphisms in the Ncf1 ... See full document

... score derived on the basis of loss in body weight, stool consistency, and appearance of blood in feces. Briefly, body weights were monitored daily, whereas stool consistency and rectal bleeding were examined every ... See full document

... renal epithelial Hif-1α is fibrogenic in a chronic renal injury model and thus exerts a disease-promoting ...tubular epithelial cells (17), has been Figure ... See full document

... without using contrasts. It has been widely applied in various kidney diseases including chronic renal failure, kidney transplantation, hypertensive kidney dysfunction, ischemic renal injury and renal tumors [8, 9]. One ... See full document

... escape. Hypoxia occurs during placenta and tumor development and was shown to activate ...combining hypoxia-mimicking treatment and 5-aza-2’deoxycytidine, a DNA demethylating agent used in anti-cancer ... See full document

... under hypoxia status, thus inhib- iting cell growth, differentiation and prolifera- ...under hypoxia environment, a series of signaling path- ways will be activated to induce the cell apopto- sis for ... See full document

... Figure 4.1 Approaches to inhibiting HIF-1 induced gene expression……………….85 Figure 4.2 DNase I footprinting experiments of polyamides and echinomycin…….86 Figure 4.3 Effects on VEGF and FLT1 ... See full document

... (CGTG to AAAA). Hep3B cells were transfected with 1 mg of the reporter plasmid using Lipofectamin 2000 (Life Technologies). After stabilized for 48 hours, the Hep3B cell lines stably harboring the reporter plasmid ... See full document

... intracellular protective proteins [18-20] that can protect cells from damage, promote the degradation and clearance of abnormal proteins, and maintain the normal physiological function of ...groups. Hypoxia ... See full document

... The foremost hypothesis regarding the initiating event in preeclampsia is that insufficient trophoblast invasion and abnormal spiral artery remodeling pla- cental ischemia, which initiates the hypoxia stress and ... See full document

... Results: In our study, we found that 96% of pregnant females had anemia of varying severity, the majority being moderately anemic. Analysis of demographics showed that anemia was more prevalent in younger (mean age was ... See full document

... Based on these findings, the diagnosis of myeloprolifera- tive neoplasm (MPN)-ET was made. The thromboreductive therapy with anagrelide within the multicenter clinical study was started when his Plt count was 1309×10 9 ... See full document

... Ulcerative colitis is somewhat slightly more common in males, whereas CD is marginally more frequent in women (female-to-male ratio range, 1:1 to ... See full document

... in hypoxia signal expression and likely secreted insulin ...containing 1 million cells, aggregates 150 μm or larger represented nearly 12% of aggregates while making up less than 2% of aggregates in ... See full document