Top PDF Epstein-Barr Virus Nuclear Antigen 1 Replication and Segregation Functions in Nasopharyngeal Carcinoma Cell Lines
Epstein-Barr Virus Nuclear Antigen 1 Replication and Segregation Functions in Nasopharyngeal Carcinoma Cell Lines
... Epstein-Barr virus (EBV) is causatively associated with the development of nasopharyngeal carcinoma (NPC), as almost all undifferentiated NPCs are comprised of monoclonal expan- sions ...
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Study of Epstein-Barr virus nuclear antigen (EBNA-1) variations: V-val type preferentially exists in biopsies of nasopharyngeal carcinoma from Vietnamese patients
... genome during cell division by binding to viral latent replication origin regions (10). Up to now, many studies attempted to identify NPC-specific EBV subtypes based on the sequence variation of ...
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Epstein-Barr Virus Nuclear Antigen 1 Interacts with Nm23-H1 in Lymphoblastoid Cell Lines and Inhibits Its Ability To Suppress Cell Migration
... Moreover, EBNA1 increased the tumorigenic potential and metastatic capability of a NPC cell line (43). These studies suggest that EBNA1 may have a direct role in contributing to the tumorigenic potential of EBV. ...
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Comprehensive Profiling of Epstein-Barr Virus MicroRNAs in Nasopharyngeal Carcinoma
... infected cell lines to suggest differential expression of EBV miRNAs in different latency states (6, 7, 10, 16, 19, 21, 27, 38, ...not cell type specific (10) and highlight the difficulties and ...
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Molecular Detection of Epstein - Barr virus in Nasopharyngeal Carcinoma among Sudanese population
... of nasopharyngeal carcinoma by several different lines of compelling ...with nasopharyngeal carcinoma were often more positive for precipitating antibodies to antigens prepared from ...
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Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment
... EBNA1-dependent replication at ...EBV-negative cell lines BJAB and DG75 and the EBV-positive cell lines Raji, LCL3456, and LCL3472 were cultured in the absence (control) or presence of ...
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Autorepression of Epstein-Barr Virus Nuclear Antigen 1 Expression by Inhibition of Pre-mRNA Processing
... Epstein-Barr virus (EBV) latent infection, and its associated oncogenic potential, is dependent on genome maintenance functions of EBV nuclear antigen 1 (EBNA-1), ...
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Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator.
... other cell lines, EBNA-3C inhibited activation of the LMP-1 promoter by ...EBNA-3C functions as an activation domain in both Gal4 and EBNA-2 chimeric ...
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Nucleosome Assembly Proteins Bind to Epstein-Barr Virus Nuclear Antigen 1 and Affect Its Functions in DNA Replication and Transcriptional Activation
... HeLa cell lysates on EBNA1 affinity ...Raji nuclear lysates with antibodies against NAP1, TAF-I (both ␣ and  subunits are recognized), or TAF-I  or with a nonspecific rabbit IgG ...Raji nuclear ...
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Epstein-Barr Virus Nuclear Antigen 1 Hijacks the Host Kinase CK2 To Disrupt PML Nuclear Bodies
... EBV replication, plasmid maintenance or tran- scriptional activation (30, 45; our unpublished data), nor is the S21 site conserved in EBNA1 homologous in the EBV-like cynomolgus monkey virus and herpesvirus ...
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Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2
... either cell line was also ...both cell lines according to the Affymetrix ...EBNA-2 functions. All published target genes were confirmed in one or both cell lines with two ...
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Triptolide inhibits Epstein-Barr nuclear antigen 1 expression by increasing sensitivity of mitochondria apoptosis of nasopharyngeal carcinoma cells
... NPC cell lines, suggesting that targeting on EBNA1 is a substantial strategy of treating EBV- positive ...PML nuclear bodies and causes PML nuclear bodies disruption [9, 10, ...
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Novel Approach to the Formulation of an Epstein-Barr Virus Antigen-Based Nasopharyngeal Carcinoma Vaccine
... Epstein-Barr virus (EBV) is associated with several malignant diseases including nasopharyngeal carcinoma (NPC), a common neoplasm throughout southeast ...protein 1 (LMP1) and ...
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Separation of the DNA Replication, Segregation, and Transcriptional Activation Functions of Epstein-Barr Nuclear Antigen 1
... Epstein-Barr virus (EBV) persists in the nuclei of latently infected human B lymphocytes as double-stranded circular DNA episomes ...DNA replication per cell cycle and are efficiently ...
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Epstein-Barr Virus Latent Membrane Protein 1 Induces Cancer Stem/Progenitor-Like Cells in Nasopharyngeal Epithelial Cell Lines
... Epstein-Barr virus (EBV) is a human herpesvirus that is associated with several malignancies, such as Burkitt lym- phoma (BL), Hodgkin lymphoma (HL), gastric cancer, and, most importantly, ...
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Epstein-Barr Virus Nuclear Antigen 3C Activates the Latent Membrane Protein 1 Promoter in the Presence of Epstein-Barr Virus Nuclear Antigen 2 through Sequences Encompassing an Spi-1/Spi-B Binding Site
... The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B ...
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mRNA Translation Regulation by the Gly-Ala Repeat of Epstein-Barr Virus Nuclear Antigen 1
... Overriding the effect of the GAr by altering the 5 ⴕ UTR. The observation that changes in the codon sequence have little effect on GAr-mediated translation suppression compared to major disruptions caused by single ...
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Epstein-Barr Virus Nuclear Antigen 3C Recruits Histone Deacetylase Activity and Associates with the Corepressors mSin3A and NCoR in Human B-Cell Lines
... with 1% NP-40 and then cleared by centrifugation and transferred to a cold, sterile microcentrifuge ...of 1:100 in phosphate-buffered ...NLS, nuclear localization signal; AD, acidic ...
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Epstein-Barr Virus Infection of Human Astrocyte Cell Lines
... our cell lines, we cannot explain this observation by the coexistence of one population latently infected with a transcription pattern close to the LCL pattern and another infected lytically (15, 41, 47, ...
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Epstein Barr virus induced autoimmune responses I Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein Barr virus nuclear antigen 1
... conserved autoepitopes. The other gene (p554) encodes a protein that is not demonstrably cross-reactive with Epstein-Barr virus nuclear antigen-1 or with any other EBV protein, ...
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