[PDF] Top 20 The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms

... The p53 gene encodes a multifunctional protein that partic- ipates in cell cycle control, programmed cell death, genomic stability, and DNA replication, transcription, and repair (42, 53, 54, ...conditions, ... See full document

... serine/threonine protein kinase and is the only protein kinase identified in the EBV genome (2, 3, 13, 14, ...viral protein kinase in the EBV life cycle is largely ...this protein kinase in ... See full document

... nuclear protein has been found to initiate basal transcription and to physically interact with SP1 and the TATA-binding protein (21, 44, ...dependent function of YY1 has been suggested and may ex- ... See full document

... of Epstein-Barr virus (EBV) is mediated by the immediate early protein BZLF1 ...Z function has not been ...of early lytic viral promoters in reporter gene ... See full document

... The Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) is a key regulator of the EBV latent-to- lytic ...EBV early gene ...CREB-binding protein ... See full document

... activators function through an interac- tion with CREB-binding protein ...include p53, NF-␬B, p65, c-Fos, c-Jun, and c-Myb, among others (5, 7, 10, 13, 19, 33, 44, ...ian virus 40 T ... See full document

... that BZLF1 expression by itself is apparently not sufficient to activate full S-phase progression in keratino- cytes or AGS cells whereas the lytically infected population of EBV-positive AGS cells has an ... See full document

... viewpoints, BZLF1 expression during latent infection may be a remnant of lytic ...were BZLF1 positive, suggesting that BZLF1-expressing cells un- dergo lytic replication and die, whereas other cells ... See full document

... RNA-binding protein DGCR8 ...binding protein, and an Argonaute protein (31, ...Argonaute protein, the mature miRNAs bind to the 3= untranslated region (UTR) of mRNAs through a highly ... See full document

... mic component of BRLF1. Thus, it is possible that BRLF1 regulates signal transduction pathways through protein-protein interactions in the cytoplasm. Alternatively, BRLF1 may tran- ... See full document

... simplex virus (HSV) ...the immediate-early gene ICP0 and can function to down regulate ICP0 production in transient assays ...antisense BZLF1 EBNA1 intron hy- bridization, a recent ... See full document

... the immediate-early protein Z alone but not R alone is sufficient to disperse PML ...replication function) are required for PML body ...this function is important for efficient lytic ... See full document

... proteins BZLF1 and BRLF1, are expressed (8, 10, 23, 35, 36, 39, ...These immediate-early genes encode transcrip- tional activators that bind to and activate EBV early gene promoters (8, 11, ... See full document

... genes. Through binding to the plasmid origin of viral replication, OriP, EBNA1 tethers the viral episome to chromosomes in dividing cells to ensure that every daughter cell retains the viral episome after mitosis ... See full document

... We have demonstrated that the spliced mRNA spanning the BZLF1 gene expresses the BZLF1 protein and is active in inducing the productive cycle of EBV in BL41/CL16 cells and in X50-7 cells[r] ... See full document

... or early were either late transcripts or transcripts whose kinetic class has not been formally ...were early lytic transcripts or transcripts whose kinetic class has not been formally ... See full document

... Epstein-Barr virus (EBV) is a gamma herpesvirus that infects approximately 85% of the ...EBV immediate-early protein BZLF1 is a transcriptional activator which binds to ... See full document

... EBNA-3A protein of Epstein-Barr virus were shown to be capable of binding to the cell protein RBP-Jk (also known as CBF-1), a component of the Notch signaling ...activation ... See full document

... The distinction between the elements involved in TPA induction and the ZIIIB domain was further demonstrated by site-directed mutagenesis, which affected ZEBRA binding and transactivatio[r] ... See full document

... To determine whether antiIgG induction of Zp and Rp in the Akata cell line is dependent on de novo protein synthesis, cells were treated with anti-IgG in the presence and absence of two [r] ... See full document