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[PDF] Top 20 Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2

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Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2

Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2

... in regulating G 1 progression of the cell cycle. These three cyclin D proteins are highly conserved in human cells, but the coding genes are located at sites on different chromosomes of the human ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity

Epstein-Barr Virus Nuclear Antigen 3C Regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity

... of cyclin A-dependent kinase activity. To determine whether rescue of cyclin A-dependent kinase activity could be mapped to the same carboxy-terminal region of EBNA3C as in vitro cyclin A binding, ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2

Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2

... Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is one of the essential latent antigens for primary B-cell ...EBNA3C facilitates degradation of several vital ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2

Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2

... FIG. 8. Proposed roles of EBNA-3C in regulating EBNA-2 trans- activation activity in EBV-infected B lymphocytes. The Wp EBNA promoter directs initial transcription of EBNA-2 and EBNA-LP mRNAs, which are ... See full document

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Regulation of Matrix Metalloproteinase 9 Expression by Epstein-Barr Virus Nuclear Antigen 3C and the Suppressor of Metastasis Nm23-H1

Regulation of Matrix Metalloproteinase 9 Expression by Epstein-Barr Virus Nuclear Antigen 3C and the Suppressor of Metastasis Nm23-H1

... tumor cell intravasation and extravasation during metastasis ...in regulating MMP-9 has not been investigated in ...mous cell carcinoma cells, Nm23-H1 can suppress cell migra- tion without ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Recruits Histone Deacetylase Activity and Associates with the Corepressors mSin3A and NCoR in Human B-Cell Lines

Epstein-Barr Virus Nuclear Antigen 3C Recruits Histone Deacetylase Activity and Associates with the Corepressors mSin3A and NCoR in Human B-Cell Lines

... EBNA3C cell lines and may be a function of the additional EBNAs expressed in EBV-trans- formed ...same nuclear com- ...in regulating chromatin acetylation and deacetylation, resulting in ... See full document

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Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2

Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2

... Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation ...cause cell cycle entry and the ... See full document

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Structural, Functional, and Genetic Comparisons of Epstein-Barr Virus Nuclear Antigen 3A, 3B, and 3C Homologues Encoded by the Rhesus Lymphocryptovirus

Structural, Functional, and Genetic Comparisons of Epstein-Barr Virus Nuclear Antigen 3A, 3B, and 3C Homologues Encoded by the Rhesus Lymphocryptovirus

... regulate cell CD21 expression and viral LMP1 expression, and all three EBNA-3s can act together to induce pleckstrin expression (1, 17, ...by regulating expression of cell genes important for acute ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B

Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B

... recombinant virus showed a reduction in cell proliferation compared to that of WT LCLs, we were interested in investigating whether this phenotype could be linked to an impairment of EBNA3C ... See full document

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Expression of Epstein-Barr Virus Nuclear Antigen 1 Is Associated with Enhanced Expression of CD25 in the Hodgkin Cell Line L428

Expression of Epstein-Barr Virus Nuclear Antigen 1 Is Associated with Enhanced Expression of CD25 in the Hodgkin Cell Line L428

... cell proliferation. Similar findings have been described for B-cell chronic lymphocytic leukemia, where the neoplastic cells expressed only the IL-2R a chain (CD25), while the b chain was only weakly ... See full document

7

Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator.

Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator.

... EBNA- 3C-mediated activation is the relief of inhibition by RBP-J k , leading to increased transcription as a result of the binding of other transcription factors to the ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Interacts with Histone Deacetylase To Repress Transcription

Epstein-Barr Virus Nuclear Antigen 3C Interacts with Histone Deacetylase To Repress Transcription

... Consistent with these functional assays, in vitro-translated HDAC1 bound to a glutathione S-transferase (GST) fusion protein including full-length EBNA3C, and in the reciprocal experiment EBNA3C bound to a GST fusion ... See full document

10

Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA.

Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA.

... FIG. 2. GAL4-EBNA3C aa11-992 strongly represses transcription when bound to DNA. (A) The Burkitt lymphoma-derived cell line DG75 was trans- fected with 5 mg of the CAT reporter construct pUASCAT in which the GAL4- ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Interacts with and Enhances the Stability of the c-Myc Oncoprotein

Epstein-Barr Virus Nuclear Antigen 3C Interacts with and Enhances the Stability of the c-Myc Oncoprotein

... Epstein-Barr virus (EBV) was the first human DNA virus to be associated with ...EBV nuclear antigen 3C (EBNA3C) is one of a small subset of latent antigens critical for ... See full document

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Transcriptional Regulatory Properties of Epstein-Barr Virus Nuclear Antigen 3C Are Conserved in Simian Lymphocryptoviruses

Transcriptional Regulatory Properties of Epstein-Barr Virus Nuclear Antigen 3C Are Conserved in Simian Lymphocryptoviruses

... Since CtBP is generally regarded as a transcriptional repressor, it is surprising that the PLDLS motif of EBNA-3C is located within its activation domain. However, CtBP can also function as a context-specific ... See full document

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Purification of the Epstein-Barr virus-determined nuclear antigen from Epstein-Barr virus-transformed human lymphoid cell lines.

Purification of the Epstein-Barr virus-determined nuclear antigen from Epstein-Barr virus-transformed human lymphoid cell lines.

... extracts of the human lymphoid cell lines Raji, Namalwa, and B95-8/MLD by two different methods.. In the first approach, the apparently native antigen was.[r] ... See full document

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Induction of Epstein-Barr virus nuclear antigen and DNA synthesis in a human epithelial cell line after Epstein-Barr virus infection.

Induction of Epstein-Barr virus nuclear antigen and DNA synthesis in a human epithelial cell line after Epstein-Barr virus infection.

... A human epithelial line (U) was found that could be directly infected by EBV, and viral functions, the induction of EBV nuclear antigen and cellular DNA synthesis, were demonstrated.. Th[r] ... See full document

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Biochemical characterization of Epstein-Barr virus nuclear antigen 2A.

Biochemical characterization of Epstein-Barr virus nuclear antigen 2A.

... However, this partially dephosphorylated EBNA-2A migrated with an intermediate mobility compared with that of the two forms of untreated EBNA-2A (compare, for instance, lanes 5 and 6 and[r] ... See full document

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Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis.

Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis.

... However, FIE on the EBNA (+), vere the antigens nonproducer cell line, Namalwa (Fig. 3B, track en 65 and 72K, C) indicates that an antigen of similar molecular formed cell line weight (i[r] ... See full document

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Epstein-Barr Virus Nuclear Antigen 3C Activates the Latent Membrane Protein 1 Promoter in the Presence of Epstein-Barr Virus Nuclear Antigen 2 through Sequences Encompassing an Spi-1/Spi-B Binding Site

Epstein-Barr Virus Nuclear Antigen 3C Activates the Latent Membrane Protein 1 Promoter in the Presence of Epstein-Barr Virus Nuclear Antigen 2 through Sequences Encompassing an Spi-1/Spi-B Binding Site

... IRF4 binding sites in the Ig ␬ enhancer, the Spi site in the LMP-1 promoter did not support the assembly of a similar complex between Spi proteins and IRF4. Instead, our data demonstrate that the ets domains of both ... See full document

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