[PDF] Top 20 Epstein-Barr Virus and the Somatic Hypermutation of Immunoglobulin Genes in Burkitt's Lymphoma Cells

... abrogate hypermutation or whether specific latency gene prod- ucts might act in concert to do so, we analyzed Ramos deriv- atives generated by de novo infection with EBV-neo, a deriv- ative of the Akata type 1 EBV ... See full document

... converted cells, the EBNA2 knockout lines, or the newly es- tablished Ava-, Oku-, and Sal-BL cells (14, ...P3HR1-converted cells and is expressed at a very low level in the nocodazole-resistant ... See full document

... Epstein-Barr virus (EBV) is present in tumor cells of more than 90% of cases of Burkitt’s lymphoma (BL) in areas of endemicity in equatorial Africa and New Guinea, as well as in tumor ... See full document

... Epstein-Barr virus (EBV) is a DNA tumor virus that is associated with the pathogenesis of endemic Burkitt’s lym- phoma, Hodgkin’s lymphoma, and posttransplant ...B cells, leading ... See full document

... tumor cells in EBVaGC tissues, indicating that EBV infection occurred in the early gastric carcinogenesis and tumor originated from the monoclonal growth of EBV infected cells ...of virus coding gene ... See full document

... cancer cells re- spond differently to the same ...of genes that may enhance a cell’s ability to survive chemotherapeutic treatment ...that cells refractory to lytic induction, via unique patterns of ... See full document

... BL cells were seeded at 9x10 4 /cm 2 in the presence of inducers or inhibitors of apoptosis, including: ionomycin (1 μ g/ml, 48 h); etoposide (50 μ M, 24 h); Fas-activating CH11 antibodies (50 ng/ml, 24 h) (all ... See full document

... simian virus 40 (SV40) promoter-driven neomycin resistance gene derived from pcDNA3 (Invitrogen) was cloned into XbaI- and XhoI-digested pBluescript II KS(⫹) (Stratagene), referred to as ...B95-8 ... See full document

... these cells than in the latently infected group I BL cells ...BL cells are clustered around positions 1 100, 1 165, and 1 195 relative to the Fp start ...Mutu cells and the long-established ... See full document

... target genes and of a subset of genes activated in GC cells but relative downregulation of other GC- associated genes, as well as of NF- ␬ B target and major histocom- patibility complex (MHC) ... See full document

... target genes, was obtained by RT-qPCR, using the specific Taqman microRNA Assays for cellular and viral miRNAs (Ap- plied Biosystems, Germany), following manufacturer’s ... See full document

... Adsorption of FITC-EBV and unlabeled EBV with SV-treated cells EBNA induction" in BJA-B cells by residual EBV' % EBNA positive Residual FITC-EBVa binding EBV adsorption with: to Raji cel[r] ... See full document

... To evaluate whether BCRF1 expression in a small fraction of cells permissive for virus replication could have a B-cell growth factor effect on neighboring latently infected cells in vivo[r] ... See full document

... However, for the following reasons we presume they represent proteolytic degradation products generated in vivo: i immunoprecipitates of COS cells electroporated with pSV2CAT a plasmid s[r] ... See full document

... The interval improvement and self-limited clinical course in our case led us to believe that her elevated ANA titers, her bone marrow granuloma were secondary to an EBV infection-related syndrome. Monospot test was not ... See full document

... In previous studies of infectious mononucleosis, we found IgM autoantibodies which react with hematopoietic cell antigens. Many of these were inhibited by synthetic glycine/alanine peptides representing the ... See full document

... EBNA genes have the Zp V3 haplotype, but the type 1 strains may have either V1 or ...EBV genes, shaded black for latent cycle genes EBNA1, EBNA3A, EBNA3B, and ... See full document

... Assay of IgA antibody to viral capsid antigen is a potentially useful adjunct in the serodiagnosis of infectious mononucleosis or recent EpsteinBarr virus infection, as are the other ant[r] ... See full document

... 3240 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The induction of the viral lytic cycle in latently Epstein-Barr virus EBV-infected B cells is initiated by activatio[r] ... See full document

... dictions of mutation involving misaligned structural intermediates mediated by either direct or inverted repeats are (1) base substitutions are templated and, hence, stron[r] ... See full document