[PDF] Top 20 Equal synthesis of α and β globin chains in erythroid precursors in heterozygous β thalassemia
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Equal synthesis of α and β globin chains in erythroid precursors in heterozygous β thalassemia
... Equal synthesis is probably due both to a decrease in a-chain synthesis and an increase in b-chain synthesis in bone marrow erythroid cells and may contribute to the absence of overt hem[r] ... See full document
5
Loss of α hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β thalassemia
... Late-stage erythroid development is largely dedicated to the produc- tion of the oxygen carrier hemoglobin (Hb) A, a tetramer consisting of two pairs of α-globin and β-globin protein ... See full document
11
Imbalance in α and β Globin Synthesis Associated with a Hemoglobinopathy
... of globin synthesis in subjects with structurally abnormal hemoglobins have generally revealed equal production of a and b polypeptide ...of globin biosynthesis in vitro in blood and marrow ... See full document
10
Investigation of RFLP Haplotypes β- Globin Gene Cluster in Beta-Thalassemia Patients in Central Iran
... Conclusion: Our study participants like beta-thalassemia patients from Kermanshah province was found to possess a similar haplotype background for common mutations. The emergence of most prevalent mutations on ... See full document
7
Diagnostic predictibility of complete blood count (cbc) in identifying thalassemia trait in pregnant females
... of β-TT is essential for the prevention of a birth of a β-TM by genetic counselling and it can be reduced to ...detect β thalassemia trait in pregnant women attending the antenatal clinic on ... See full document
5
Scoliosis in β Thalassemia
... Rotation of the Apical Vertebra of the Major Curvature According to Nash and Moe” in fi Thalassemic Patients With Scoliosis*.. Location of Sco- Direction Grade of Rotation.[r] ... See full document
7
Immunostick Test for Detecting ζ-Globin Chains and Screening of the Southeast Asian α-Thalassemia 1 Deletion
... detect α-thalassemia 1 carriers with high sensitivity [11, ...(−-(SEA)) α-thalassemia-1 trait, ζ- globin chains have been reported to be present in red blood cells ... See full document
11
Synthesis, Reactions and Biological Importance of α, β-Unsaturated Carbodithioate Esters: A Review
... of α, β-unsaturated dithioesters [4], (iii) base catalyzed elimination of β-hydroxy dithioesters [5], and (iv) Wittig–Horner, Peterson or Mukaiyama type condensation reactions of aldehydes and ... See full document
8
Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
... chicken β-globin gene domain in red blood cells of em- bryonic and adult ...the β-globin gene cluster form a complex with the β/ε en- hancer located in the downstream portion of the ... See full document
11
Relationship of Thyroid Hormone Status with Iron Overload in the Βeta-Thalassemic Tribal Children Receiving Multiple Blood Transfusions- A Cross-Sectional Descriptive Study
... of β-thalassemia had been studied for evaluating the relationship between iron overload with thyroid ...among β-thalassemia major patients and female patients affected much in hypothyroidism ... See full document
6
Amantadine Plus Interferon-α Versus Interferon-α Monotherapy for the Treatment of Chronic Hepatitis-C Infection in β-Thalassemia Major Patients: A Randomized Double Blinded Pilot Study in Shiraz, Iran
... Materials and Methods: Forty six thalassemia major patients who were chronically infected with HCV were randomly divided into two groups. One group (22 patients) was treated by INF-α, 3 million units every ... See full document
5
Globin chain synthesis in the alpha thalassemia syndromes
... alpha thalassemia trait, and the “silent carrier” state were incubated with leucine- 14 C for definition of relative rates of production of alpha and beta chains in these ...The chains were separated ... See full document
9
Process for the synthesis of α, β unsaturated esters
... During the irradiation of 13.3 mM FeCO5 and methyl oleate in hexanes at 20° C., the highest yield 58% of the ot,[3-ester 7 Was obtained after 1 hour; this is a loWer yield than that 70% [r] ... See full document
15
Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements
... the β -globin locus for Ldb1 (A, B) or Ctcf (C, D) for mouse primary erythroid cells (A, C) and mouse fetal brain cells (B, D) from ...the β -globin locus is clearly depicted in the ... See full document
17
Non contiguous-finished genome sequence and description of Peptoniphilus obesi sp. nov.
... production, α-arabinosidase, α-glucosidase, α-fucosidase, β-galactosidase, glutamic acid de- carboxylase, 6-phospho-β-galactosidase β- glucosidase, β-glucuronidase, ... See full document
13
An erythroid chaperone that facilitates folding of α globin subunits for hemoglobin synthesis
... in erythroid cells AHSP stabilizes newly formed α-globin transiently and then passes it off to βHb to form ...heavy chains are sta- bilized in the ER by the molecular chaperone BiP ...light ... See full document
11
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... some β- thalassemia or Hb E or S carrier mothers in their reproductive life either had spontaneous abortions or neonatal deaths [Table/fig 2], [Table/fig ...or β-thalassemia in ...cell- ... See full document
9
Understanding globin regulation in β thalassemia: it’s as simple as α, β, γ, δ
... non–α-globin chains and avoid the excess α-globin toxicity primarily respon- sible for anemia in human ...of globin regulation, such as those of Han et ... See full document
5
Original Article β-thalassemia for translating human β-globin gene and RNA interference of α-globin gene expression by lentivirus vectors
... normal globin sequence that had no thalassemia through gene detection in the Guangxi Key Laboratory of ...human β-globin (American Abnova Corporation), Mouse monoclonal anti- body against ... See full document
10
Study on Clinical Profile of Beta Thalassemia Major Children
... In some of the developing countries individuals with thalassemia major are either untreated or transfused inadequately. Persistent severe anemia leads on to various consequences in these patients. The common ... See full document
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