[PDF] Top 20 Essential Functions of the Unique N-Terminal Region of the Varicella-Zoster Virus Glycoprotein E Ectodomain in Viral Replication and in the Pathogenesis of Skin Infection
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Essential Functions of the Unique N-Terminal Region of the Varicella-Zoster Virus Glycoprotein E Ectodomain in Viral Replication and in the Pathogenesis of Skin Infection
... most viral particles, although envelope gE was detected on fewer virions than in the rOka-infected cells, where almost every viral par- ticle was labeled ...most viral particles had gE incorporation ... See full document
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Functions of the C-Terminal Domain of Varicella-Zoster Virus Glycoprotein E in Viral Replication In Vitro and Skin and T-Cell Tropism In Vivo
... enhanced replication is ...the N terminus, accelerated growth in vitro and was associated with more-extensive infection of skin xenografts ...in skin in ...human skin cells, to ... See full document
10
Deletion of the First Cysteine-Rich Region of the Varicella-Zoster Virus Glycoprotein E Ectodomain Abolishes the gE and gI Interaction and Differentially Affects Cell-Cell Spread and Viral Entry
... unique N-terminal region (3, 4, 34, ...The unique short segment of the VZV genome en- codes only gE and gI, whereas the other alphaherpesviruses have gD, as well as gE and gI, at this ... See full document
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ORF11 Protein Interacts with the ORF9 Essential Tegument Protein in Varicella-Zoster Virus Infection
... is essential for VZV replication, whereas VP22 is dispensable, and ORF9 protein local- izes almost exclusively to the cytoplasm, while VP22 traffics be- tween the cytoplasm and nucleus ...to ... See full document
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Identification of a Hydrophobic Domain in Varicella-Zoster Virus ORF61 Necessary for ORF61 Self-Interaction, Viral Replication, and Skin Pathogenesis
... simian varicella virus (SVV), equine herpesvirus (EHV), and feline herpesvirus (FeHV) orthologs ...this region between VZV ORF61 and the SVV ortholog was ⬃ 65% compared to ⬃ 23 to 27% in EHV and FeHV ... See full document
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Cellular and Viral Factors Regulate the Varicella-Zoster Virus gE Promoter during Viral Replication
... causes varicella (chickenpox) during primary infection; VZV establishes latency in the sensory ganglia and reactivation causes herpes zoster (shingles) ...VZV glycoprotein E (gE), a ... See full document
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Glycoprotein E of Varicella-Zoster Virus Enhances Cell-Cell Contact in Polarized Epithelial Cells
... molecules E-cadherin and MDCK desmocollin (9, ...gE, E-cadherin, and desmocollin were similar in size and that these segments had regions of similarity and identity not found in comparing their cytoplasmic ... See full document
11
Characterization of Neutralizing Epitopes of Varicella-Zoster Virus Glycoprotein H
... body clones were compared with the germ line sequences listed in VBASE (VBASE Directory of Human V Gene Sequences; http://vbase.mrc-cpe.cam.ac.uk/). The original germ lines for clones 10 and 431, which recognize one ... See full document
5
Impact of Varicella-Zoster Virus on Dendritic Cell Subsets in Human Skin during Natural Infection
... of virus in human immature DC but not mature DC ...VZV skin infection and the impact VZV infection may have on DC subsets has yet to be ...the skin and which may be involved in the ... See full document
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Varicella-Zoster Virus Infection Induces Autophagy in both Cultured Cells and Human Skin Vesicles
... replicate infection was harvested to provide a baseline control, and PAA treat- ment was initiated at either 24 or 30 ...PAA-sensitive viral gene ... See full document
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Essential Role Played by the C-Terminal Domain of Glycoprotein I in Envelopment of Varicella-Zoster Virus in the trans-Golgi Network: Interactions of Glycoproteins with Tegument
... trans-Golgi network (TGN) (10, 30). An analogous mechanism has been postulated to be involved in the envelopment of pseudorabies virus (33). The glycoproteins of VZV are tar- geted to the TGN and, in infected ... See full document
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The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication.
... fected cells with an antibody specific for ORF66 protein. To produce the antibody to the ORF66 protein, the carboxyl por- tion of ORF66 was amplified from cosmid VZV MstIIA by PCR with oligonucleotides ... See full document
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Varicella zoster virus ORF 58 gene is dispensable for viral replication in cell culture
... Varicella-zoster virus (VZV) is a member of the herpesviri- dae family, and its primary infection causes varicella in ...causing zoster in aged and immunosuppressed indi- viduals ... See full document
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Hospital Infection Control for Varicella Zoster Virus Infection
... 200 VARICELLA ZOSTER VIRUS INFECTION and those with varicella are placed in strict isolation until 28 days following exposure or until all lesions are crusted.. Strict isolation requires[r] ... See full document
6
Infection of Human T Lymphocytes with Varicella-Zoster Virus: an Analysis with Viral Mutants and Clinical Isolates
... of virus in hu- man T cells in ...study infection of human lymphocytes in vitro. Infection of human cord blood mononuclear cells in vitro with recombinant Oka strain VZV (ROka) followed by ... See full document
7
Anti-Glycoprotein H Antibody Impairs the Pathogenicity of Varicella-Zoster Virus in Skin Xenografts in the SCID Mouse Model
... in viral titer and genome copy number for both antibody-treated ...of viral titers and genome copy numbers. VZV lesion spread in skin xenografts was reduced following treatment with anti-gH MAb ... See full document
12
Rapid diagnosis of varicella zoster virus infection by detection of viral deoxythymidine kinase in serum and vesicle fluid
... An investigation of 16 coded vesicle fluid specimens, taken in connection with varicella-zoster virus VZV and herpes simplex virus infections, revealed viral dTk activity in 14 samples..[r] ... See full document
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The Surface Glycoprotein of Feline Leukemia Virus Isolate FeLV-945 Is a Determinant of Altered Pathogenesis in the Presence or Absence of the Unique Viral Long Terminal Repeat
... study, virus 61E/945SL bearing both the LTR and env gene of FeLV-945 again induced non-T-cell disease, in this case a large cleaved-cell lym- phoma that involved multiple organs but excluded the ...recombinant ... See full document
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The Epstein-Barr virus glycoprotein 110 carboxy-terminal tail domain is essential for lytic virus replication.
... third glycoprotein, gp42, which has no known relatives in the other human herpesviruses (12, 14, 17, 21, 26, ...for infection of B lymphocytes but not of epithelial cells ...be essential for ... See full document
6
Molecular Analysis of Varicella Vaccines and Varicella-Zoster Virus from Vaccine-Related Skin Lesions
... German varicella sentinel (16), specimens from vaccinated individuals with rashes were subjected to VZV PCR and PSQ for differentiation between wt VZV and vaccine-type VZV by analyzing five SNP positions (nt ... See full document
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