Top PDF Evaluation of Anti-Ulcer Activity of Leaf Extract of Nelumbo Nucifera in Rats

Evaluation of Anti-Ulcer Activity of Leaf Extract of Nelumbo Nucifera in Rats

Evaluation of Anti-Ulcer Activity of Leaf Extract of Nelumbo Nucifera in Rats

Nelumbo nucifera has long been used as a folk medicine in treatment of diarrhoea, fevers, bleeding and other inflammatory conditions. Therefore, the present study was designed to investigate the antiulcer effect of hydroalcoholic extract of leaves of Nelumbo nucifera. The hydroalcoholic leaf extract of Nelumbo nucifera was subjected to phytochemical screening which confirmed the presence of alkaloids, flavonoids, tannins, phytosterols and saponins. Acute gastric ulceration in rats was produced by oral administration of various noxious chemicals including indomethacin, ethanol, pylorus ligation technique and by subjecting the animals to cold restraint stress. The extract was administered in three different doses of 100, 200 and 400 mg/kg orally in all the experiments. The dose was calculated based upon acute toxicity studies. Ranitidine and Misoprostol were used as the standard drugs. The antiulcer activity was assessed by determining and comparing the ulcer index of the test group with that of the vehicle control group and standard group. The antiulcer potency was evaluated by determining and comparing the ulcer idex of the test group with that of the vehicle control group and standard group. The antiulcer activity was however less than the standard drugs. The above may be due to the presence of flavonoids, tannins and other phytoconstituents in the plant extract.
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Evaluation of anti-ulcer activity of the leaf extract of <em>Osyris quadripartita</em> Decne. (Santalaceae) in rats

Evaluation of anti-ulcer activity of the leaf extract of <em>Osyris quadripartita</em> Decne. (Santalaceae) in rats

the dose and is comparable with that of the standard drug. The repeated-dose study for ethanol-induced ulcer model showed a significant reduction in ulcer score (P < 0.001) and ulcer index (P < 0.001) in the 10-day and 20-day pretreat- ment with OQ200 and S100. This finding signifies that the extract possesses a gastroprotective effect, which is as good as the standard drug. The repeated-dose study with OQ200 showed a better reduction in percentage of ulcer inhibition, (71.48% for 10 days and 85.35% for 20 days) as compared to the single-dose study for OQ200 (54.3%) and OQ400 (62.11%). This suggests that the cumulative ulcer healing effect of the extract is better than that of the single dose in this model. The results of the present study showed that the OQ leaf extract was capable of inhibiting gastric lesions formed by ethanol. Absolute alcohol would extensively damage the gastric mucosa leading to increased infiltration of neutrophils, which are a major source of inflammatory mediators. Therefore, suppression of neutrophil infiltration during inflammation was found to enhance gastric ulcer healing. 33,34,39 OQ leaf extract has been shown to contain
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EVALUATION OF ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS

EVALUATION OF ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS

INTRODUCTION: Peptic ulcer is a conglomerate of heterogeneous disorders, which manifests itself as a break in the lining of the gastrointestinal mucosa bathed by acid and pepsin 1 . It is characterized by the disruption of the mucosal integrity of the esophagus, stomach, or duodenum. As the most common gastrointestinal disturbance, it affects 10-15% of the population at any one time

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Evaluation of the Anti Hyperlipidemic Activity of  Nelumbo nucifera  Fruit in Rabbits Fed with High Cholesterol Diet

Evaluation of the Anti Hyperlipidemic Activity of Nelumbo nucifera Fruit in Rabbits Fed with High Cholesterol Diet

A population of 28 white healthy rabbits of either sex was divided in to four groups. Control group was given gum tragacanth and 3 groups served as test groups and were given N. nucifera fruit extract 50, 100 and 200 mg/kg for 45 days. Initially animals of all four groups received high cholesterol diet (HCD) i.e. 0.125 gm/kg cholesterol in 0.5% corn oil for 30 days. All agents were given PO [16]. Blood samples were taken thrice from the ear vein of animals, 1st after 24 hours of thirty days of HCD then again after 24 hours of thirty and forty five days dosing of N. nucifera fruit extract i.e. on 31st and 46th day of experiment.
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Evaluation Of Anti -Ulcer Activity of Alcoholic Extract of Hibiscus Rosa Sinesis In Rats.

Evaluation Of Anti -Ulcer Activity of Alcoholic Extract of Hibiscus Rosa Sinesis In Rats.

Albino rats weighing between (160-200 gm were divided into 8 groups of 6 rats in each. They were fasted in individual cages with measures taken to avoid coprophagy for 24 h prior to the experiment with free access to water. Group A was served as normal control given with vehicle only. Group B with standard drug, groups C, D, E were treated with low, medium and high doses of HAHR [7, 9]. The various groups were treated with vehicle/drug/ extracts 30 min prior to pylorus ligation and the details of the protocol was given below:
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Studies on the Hypoglycemic and Hypolipidemic Effects of Nelumbo nucifera Leaf in Long Evans Rats

Studies on the Hypoglycemic and Hypolipidemic Effects of Nelumbo nucifera Leaf in Long Evans Rats

Lipid disorders are usually associated with diabetes which in turn acts as one of the prime causative factors for cardiovascular morbidity and mortality in pa- tients suffering from diabetes [1]. The most common diabetes is type II diabetes which accounts for about 90% of the diabetic population [1] affecting minimum 15 million people which is directly connected with other difficulties including hypertension, atherosclerosis and microcirculatory disorders [2]. Among all the endocrine disorders, diabetes mellitus is the most prevalent one and almost three hundred million will suffer from the disease by 2025 [3] and major portion of diabetic population will be from India, China and United States [4] [5]. Accord- ing to the current conducted epidemiological study in Bangladesh, more than 11% diabetic population are attacked by type II diabetes and the prevalence of impaired fasting glucose, which triggers the inception of diabetes, exceeds 6% in Dhaka city [6]. Therefore, it is now inevitable to move forward for a sophisti- cated oral drug that will be therapeutically effective as hypoglycemic side by side hypolipidemic agents at low cost particularly both for the developing and un- der-developed countries. For biological activities evaluation, as animal models, mainly rats, mice, rabbits or guinea pigs etc. are used. In the studies of hypogly- cemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). For the hypolipidemic activity investigation, the selected animals are normally fed high fat diet to originate hyperlipidemia inside those animals. It is known that over 400 species around the world have been enlisted to exhibit hypoglycemic hypolipidemic effects, although very limited number has been considered [7] [8] [9] [10]. Ethnopharmacological studies reveal that more 1200 plants are utilized in traditional medicine for their alleged hypogly- cemic activity [11].
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ANTI ULCER ACTIVITY OF AQUEOUS EXTRACT OF ANNONA SQUAMOSA LEAVES ON RATS

ANTI ULCER ACTIVITY OF AQUEOUS EXTRACT OF ANNONA SQUAMOSA LEAVES ON RATS

Most of the studies demonstrate the importance of natural products in drug discovery. The use of phytoconstituents as drug therapy to treat major ailments has proved to be clinically effective and less relatively toxic than the existing drugs. The acute oral toxicity study result showed that the plant leaf is safe. Peptic ulcer describes a condition in which there is a discontinuity in the entire thickness of the gastric and duodenal mucosa that persists as a result of acid and pepsin in gastric juice. Peptic ulcer disease (PUD) is a serious gastrointestinal disorder that requires a well- targeted therapeutic strategy. It includes number of drugs such as proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, Peptic ulcer occurs due to an imbalance between aggressive (acid, pepsin) and defensive (gastric mucosal barrier) factors of gastric mucosa.
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INVESTIGATING THE ANTIBACTERIAL EFFECTS OF LEAF EXTRACTS OF NELUMBO NUCIFERA ON FIVE TESTED PATHOGENS

INVESTIGATING THE ANTIBACTERIAL EFFECTS OF LEAF EXTRACTS OF NELUMBO NUCIFERA ON FIVE TESTED PATHOGENS

In conclusion, of the present investigation, Nelumbo nucifera contain potential antibacterial components that may be of great use for the development of new antimicrobial drugs against various diseases. The result also indicates that all the three extracts possess inhibitory activity against the tested organisms at highest concentration and also provides a baseline information on the possible use of this plant in the treatment of bacterial infections.

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Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats

Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats

The barks were shade dried for 2 weeks. The dried barks were further chopped into small pieces and reduced to powder. The powdered barks were divided into two parts, one part was macerated in 97% methanol for 72 hours to give the crude methanolic extract while the other part was successively and gradiently macerated for 72 hours in distilled Water. The liquid filtrates were concentrated and evaporated to dryness in vacuum 40°C using rotary evaporator. The 2% yield of each extract was calculated. The dry extracts were stored in a

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<p>Evaluation of the antidiarrheal activity of the leaf extract of <em>Parquetina nigrescens</em> and formulation into oral suspensions</p>

<p>Evaluation of the antidiarrheal activity of the leaf extract of <em>Parquetina nigrescens</em> and formulation into oral suspensions</p>

Rats of either sex were divided into four groups of fi ve rats, each. 16 The animals were fasted for 18 hrs prior to the test. Group I rats were treated with normal saline (2 mL/kg), which served ascontrol, while Group II received loperamide (5 mg/kg). Group III received 5 mg/kg extracts of Pn and Group IV received 200 mg/ mg extracts of Pn. All doses were administered orally. After 1 hr, all groups received 1 mL of castor oil orally. The animals were placed in cages lined with adsorbent papers and observed for 4 hrs for the presence of diar- rhea de fi ned as watery (wet), unformed stool. The con- trol group result was considered as 100%. The activity of each group was expressed as percent inhibition (%) of diarrhea. The percentage inhibition of defecation was calculated as follows:
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In vitro anticoagulant activity of Nelumbo nucifera leaf extracts on normal healthy blood plasma

In vitro anticoagulant activity of Nelumbo nucifera leaf extracts on normal healthy blood plasma

noticed a correlation between concentration of aqueous extract of Allium cepa and the time needed to inhibit the clot formation with a prolonged PT. That is, as concentration increases, the aqueous extract of red onion strongly inhibited the coagulation process and also increased the PT. In this investigation, an similar correlation exists between concentration of extracts and the time taken to inhibit the clot formation. This may be attributed due to the presence of several phytochemical compounds that have been noted in the extracts of leaves.

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ANTI  ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS VIRGINIANA IN RATS

ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS VIRGINIANA IN RATS

antagonists and other non-steroidal anti-inflammatory drugs has shown adverse effects, relapses, drug interactions. Medicinal plants containing active chemical constituents are useful in prevention and treatment of various diseases. Literatures suggest that herbal formulations of medicinal plants are considered to be potential source for the treatment of ulcers. This study was focused to evaluate the protective activity of Diospyros virginiana leaf and bark ethanolic extracts against HCL- ethanol induced ulcers. This plant both extracts significantly reduced the ulceration induced by acid alcohol when compared to that of standard ranitidine.
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EVALUATION OF ETHANOLIC EXTRACT OF ROOTS OF TRIANTHEMA TRIQUETRA FOR ANTI-ULCER ACTIVITY IN ALBINO RATS

EVALUATION OF ETHANOLIC EXTRACT OF ROOTS OF TRIANTHEMA TRIQUETRA FOR ANTI-ULCER ACTIVITY IN ALBINO RATS

ethanolic extract of T. triquetra 200mg/kg and 400mg/kg and ethanol orally. The gastric ulcers were induced in rats by administrating absolute ethanol (90%) (0.5ml/100g) orally, after 45 min of test dose and omeprazole treatment. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. The animals were anaesthetized after 1hr with anaesthetic ether and stomach was incised along the greater curvature and ulceration was scored.

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EVALUATION OF ANTIOXIDANT AND ANTI ULCER ACTIVITY OF SMILAX PERFOLIATA LINN

EVALUATION OF ANTIOXIDANT AND ANTI ULCER ACTIVITY OF SMILAX PERFOLIATA LINN

ABSTRACT: The leaves and fruits of Smilax perfoliata are traditionally used for treatment of various ailments such as rheumatism, lumbago, nourishing the functions of spleen, stomach, muscle and bone. The intent of the present study was to evaluate the antioxidant and anti-ulcer activity of ethanolic leaves and fruits extract of Smilax perfoliata Linn in albino rats. Gastric ulcers were induced by employing pylorus ligation method of induction. The anti-ulcer activity was analyzed by estimation of free acidity and the total acidity. The antioxidant potential was analyzed by method of DPPH free radical scavenging activity. The results obtained showed that the leaves and fruits of Smilax perfoliata possess antioxidant potential and are capable in the ministration of gastric ulcers.
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Evaluation of the anti ulcer properties of aqueous leaf extract of Dialium guineense (Velvet Tamarind) on experimentally induced ulcer models in rats

Evaluation of the anti ulcer properties of aqueous leaf extract of Dialium guineense (Velvet Tamarind) on experimentally induced ulcer models in rats

formation, reduce gastric acid secretion and inhibit pepsinogen production thereby reduced gastric lesions and ulcers. Flavonoids are among the cytoprotective materials for which antiulcerogenic efficacy has been extensively confirmed (Di Carlo et al., 1999; Borrelli et al., 2001; Galati et al., 2001). It is suggested that, these active compounds would be able to stimulate mucus, bicarbonate and the Prostaglandin secretion and counteract with the deteriorating effects of reactive oxidants in gastrointestinal lumen (Salvayre et al., 1982; Asuzu and Onu, 1990; Suja et al., 2002). Other components like alkaloids, saponins, and tannins are also present in the leaf extract of D. guineense which tend to exhibit some anti inflammatory and anti-oxidant properties (Ghosal et al., 1996; Nwaogu et al., 2007). It is obvious that the decrease in gastric ulceration, with concomitant in the gastric mucus secretion produced by the leaf extract of D. guineense in this study could be due to the presence of these components or some other mechanisms yet unidentified. This indicates that D. guineense can be subjected to further studies in order to isolate the active ingredients in the leaves as well as determine the mechanism of action of such active ingredients. These may ultimately yield better anti-ulcer agents than we have in the market today. In conclusion, the present study have established the anti-ulcer effects of aqueous extract of D. guineense leaves and further justifies the folkloric uses of the decoction of the leaves for the treatment of gastric ulcer.
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Phytochemical Screening, Isolation, and Characterization & Biological Evaluation of Ethanolic Extract of Nelumbo Nucifera Leaf.

Phytochemical Screening, Isolation, and Characterization & Biological Evaluation of Ethanolic Extract of Nelumbo Nucifera Leaf.

Yao Xue Xue Bao. 1992; 27(12):881-5. Chinese.Wang JL, Nong Y, Jing MX. : They have Liensinine(Lien), an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action, its mechanism may be related to blockade of Ca2+, Na+ influx. Lien 3 mg/kg i.v. may temporarily inhibit all parameters of haemodynamics in anesthetized or pithed rats.The inhibitory effects on LVP, +dp/dtmax and SAP in anesthetized rats are slightly stronger than those of quinidine (Qui) 3 mg/kg. Lien 1-30 mg/kg dose-dependently produced these actions.
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 INFLUENCE OF NELUMBO NUCIFERA EXTRACTS ON EXPLORATORY AND DESPAIR BEHAVIOR OF RATS

 INFLUENCE OF NELUMBO NUCIFERA EXTRACTS ON EXPLORATORY AND DESPAIR BEHAVIOR OF RATS

The present study was aimed at the experimental research of the psychotropic action of the seeds, leaves, petals and fruit extracts of Nelumbo nucifera grown in Astrakhan. In the article we study general motor activity, exploratory behavior, anxiety and behavior of despair of adult rats after treatment with extracts of seeds, leaves, petals and fruits of Nelumbo nucifera. The animals of experimental groups received intra gastric Nelumbo nucifera extracts for 14 days. Exploratory behavior and anxiety of rats were studied using Suok-test. Despair behavior of rats was studied using Porsolt test. It was found that seeds, leaves, petals and fruits extracts of Nelumbo nucifera contributed to the activation of exploratory behavior patterns and to a decrease of anxiety in animals in the Suok-test. More significantly, the behavior of animals in the Suok test was altered by the action of extracts of petals and fruits of the Nelumbo nucifera. These extracts have shown antidepressant activity in Porsolt test. The fruit extract of Nelumbo nucifera showed the most vivid antidepressant properties.
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ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF NELUMBO NUCIFERA LEAVES

ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF NELUMBO NUCIFERA LEAVES

Many common plants seen in the Kitchen gardens or in the compound or in the forests are used by the tribal as medicines. The objectives of the present investigation are to record the anti-microbial activity of the medicinal plant nelumbo Nucifera (family - Nelumbonaceae.). [1] Among the herbal medicine, lotus leave is one of the plants which have some medicinal properties in it. The lotus type which used in this research is known as sacred lotus (N.nucifera), very native to Asian, it is commonly cultivated and also used in Chinese medicine. The aim of this research is to determine whether the extract of the lotus leaf have any anti- microbial properties. There are many ways to treat or heal the disease. One of the safe methods is by treating with herbal medicine, which are derived from plants and are normally known free from side effect, toxicity effect and are very economical. Most of the people are not aware of such information. There is a belief that plants have compounds such as glycosides, carbohydrates, alkoloids, tannins, saponins, and flavonoids in them. Therefore to prove the presence of these compounds in the N. nucifera leaves certain scientific tests will be carried out on the plant, to know whether the
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COMPARATIVE EVALUATION OF THREE INDIAN MEDICINAL PLANTS FOR THEIR ANTIULCER AND ANTI- OXIDANT ACTIVITIES IN ALBINO RATDr. Shweta Sao*,  Saurabh DubeyDOWNLOAD/VIEW

COMPARATIVE EVALUATION OF THREE INDIAN MEDICINAL PLANTS FOR THEIR ANTIULCER AND ANTI- OXIDANT ACTIVITIES IN ALBINO RATDr. Shweta Sao*, Saurabh DubeyDOWNLOAD/VIEW

Ehsan Oskoueian et al 2011 reported that the latex and leaf extract of J. curcas showed highest antioxidant activity. Root and latex extracts inhibited the inducible nitric oxide synthase in macrophages RAW 264.7, comparable to L- nitro arginine methyl ester, indicating appreciable anti-inflammatory activity. Cytotoxic assays results indicated the anticancer therapeutic property of root extract against human colon adenocarcinoma (HT-29) cell lines but cytotoxic effect on human hepatocyte was high. Leon F. Villegas et al 1997 reported that J. curcas extracts shows significant wound healing activity in gastric ulcers.
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Pharmacological and therapeutic potential of Oxalis corniculata

Pharmacological and therapeutic potential of Oxalis corniculata

Bustani Hummaz (garden variety) is beneficial in the treatment of safrawi amraz (bilious diseases). Gargling with decoction of its leaves relieves marze akala (stomatitis), it has beneficial effect in treating bilious vomiting, and palpitation. Its lotion is used as a wash for snake bite, the decoction of leaves is used in treatment of Khanazir (cervical lymphadenitis) and paste of leaves is used to treat skin diseases like Quba (ringworm), Shiqaqe Nakhun and Dakhas (Koilonychia). Its local application with vinegar is useful in ailment of Azme tehal (spleenomegaly). It is also useful in treating Qarahe Isnaa shari (duodenal ulcer) and diarrhoea if cooked in Raughane Zaitoon (Olive oil) with Zeera (Cumin seed), Kishneez (Coriander seed), and Anardana (Pomegranate). It is used in Bars (leucoderma) and Qarahe Shahdia along with Rose oil and Saffron. The juice of leaves is Mukhrije Sang Gurdah wa Masana (lithotripter). It is one of the best remedy for treating Gaseeyan wa Safravi Qai (nausea and bilious vomiting), Pica (eating soil and chalk habit), Alcoholism (Wine addiction), Yarqan (Jaundice), Warme Muzmin (chronic inflammation), Ehtebase tams (Amenorrhea), Wajae Dandan (toothache), Illate Tahrike Mevi (Irritable bowel syndrome), Wajaul uzn (Otitis media), Warme Meda (Gastritis) and Gazeedane Aqarab (scorpion sting).The great Unani physician Ibne Sina (Avicenna) said that hummaz is useful in management of cuts, wounds, swelling, insect
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