Top PDF Evaluation of anti inflammatory activity on the leaves of Filicium decipiens in experimental animal models

Evaluation of anti inflammatory activity on the leaves of Filicium decipiens in experimental animal models

Evaluation of anti inflammatory activity on the leaves of Filicium decipiens in experimental animal models

Filicium decipiens (Family: Sapindaceae), whose common name is Japanese Fern Tree, was given its name because of the large fern like leaves. The leaves are compound and very large. Each leaf consist of 12 to 16 leaflets. Each leaflet is 4 to 6 inches in length and relatively narrow. The Japanese Fern Tree is a fairly slow grower, reaching a top size of 35 feet by 35 feet. It is evergreen, and will tolerate almost any soil conditions. Moisture requirement are average, and it is draught tolerant after it becomes established [4]. Studies undergone in the plant were comparatively low and the studies undergone showed that the plant constitutes saponins [13] and glycosides [14]. Anti-inflammatory activities of many plants have been attributed to their high sterol/ triterpenoid saponin content [12]. As there is no reference in literature regarding Filicium decipiens in their anti-inflammatory aspects, it was considered worthwhile to study the anti- inflammatory activity of ethanolic and aqueous extracts of leaves of filicium decipiens in rats.
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Analgesic and Anti-Inflammatory Activities of Ethanolic Extract of Leaves of Punica Granatum L. on Experimental Animal Models

Analgesic and Anti-Inflammatory Activities of Ethanolic Extract of Leaves of Punica Granatum L. on Experimental Animal Models

The present study was designed to evaluate the analgesic and anti-inflammatory activity of the ethanolic extracts of leaves of Punica granatum Linn. (EEPG). The extract was prepared by percolation method and acute oral toxicity test was performed as per OECD guidelines. The central analgesic activity was assessed using tail-flick method. The peripheral analgesic activity was assessed using acetic acid induced writhing method. Anti-inflammatory activity was assessed using carrageenan induced paw edema. It has been shown that EEPG (500 mg/kg s.c) and pethidine (5 mg/kg s.c) significantly increased the pain threshold as assessed by increase in the latency period or basal reaction time. Naloxone (1mg/kg s.c) was used to find the central mechanism of action. EEPG (500 mg/kg s.c) combined with naloxone (1 mg/kg s.c) significantly decreased the latency period indicating some agonistic activity of EEPG for the opioid receptors as the probable mechanism of action. EEPG(500 mg/kg p.o) and aspirin(100 mg/kg p.o) also significantly reduced acetic acid induced writhing response showing peripheral analgesic activity. It has also been shown that EEPG (500 mg/kg orally) and aspirin (100 mg/kg p.o) significantly reduced carrageenan induced paw edema. The result, thus justifies the traditional use of Punica granatum in inflammatory and painful conditions.
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In in vivo evaluation of the anti inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

In in vivo evaluation of the anti inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

Among the 13 species medicinal plants in MNZQ, M. chamomilla and Glycyrrhiza have been widely used to eliminate inflammation for centuries. Main beta-carboline alkaloids harmine can significantly de- crease xylene-induced ear edema and carrageenan- induced rat hind paw edema [43]. It was confirmed that the mechanism on anti-inflammatory activity of P. harmala alkaloids is to inhibit myeloperoxidase [31]. There are increasing evidences that flavonoids and phen- olic acids substance have good anti-inflammatory effects. The extract of Glycyrrhiza contains a large number of flavonoids, isoflavonoids, chalcones, and triterpene sapo- nins, including liquiritin, isoliquiritin, glycyrrhizic acid, and liquiritigenin, which have been demonstrated poten- tial anticancer, antiviral, and anti-inflammatory activities [44, 45]. Given its anti-inflammatory and analgesic proper- ties, M. chamomilla has been used for centuries as a medicinal plant. Among the constituents of aqueous M. chamomilla extract, the main ingredients of apigenin 7- O-glucoside, apigenin exerts strong anti-inflammatory activity against pro-inflammatory agents. In rats, apigenin 7-O-glucoside can inhibit skin inflammation caused by the application of xanthine–oxidase and cumene hydro- peroxide [45, 46]. Thus, these medicinal plants and their active components may be responsible for the anti- inflammatory activity of MNZQ.
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EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF THE NOVEL DERIVATIVES OF 1, 3, 4-OXADIAZOLE IN EXPERIMENTAL ANIMAL MODELS

EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF THE NOVEL DERIVATIVES OF 1, 3, 4-OXADIAZOLE IN EXPERIMENTAL ANIMAL MODELS

Analgesic activity was carried out by Eddy’s hot plate method. Six groups of albino mice of either sex each comprising of four animals. The derivatives of 5-[4-(morpholin-4- yl) phenyl]-1, 3, 4-oxadiazol-2-ol (SMRB5- 6A-6N) have shown a significant Analgesic activity. Results are tabulated in table No 4 and Graph No 3. The compounds SMRB5-6A and SMRB5-6F have shown potent Analgesic activity. The compounds SMRB5-6C, SMRB5-6E and SMRB5-6M showed a moderate analgesic activity. The other compound also showed a significant analgesic activity till 120 minutes 15 .
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Evaluation of Anti-Ulcer and Anti-Inflammatory Activity of  Ethanolic Extract of Solanum Pubescens Willd Leaves on  Experimental Animals.

Evaluation of Anti-Ulcer and Anti-Inflammatory Activity of Ethanolic Extract of Solanum Pubescens Willd Leaves on Experimental Animals.

List of Anti-ulcer plants Plant Family Plant part used Alpinia allughas Zingiberaceae Rhizome Alpinia galangal Zingiberaceae Rhizome Alpinia calcarata Zingiberaceae Rhizome Glycyrrhiza g[r]

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Evaluation of Anti-inflammatory and Analgesic Activities of Tithonia diversifolia in Experimental Animal Models

Evaluation of Anti-inflammatory and Analgesic Activities of Tithonia diversifolia in Experimental Animal Models

Pharmacologically, the plant has been reported for anti-inflammatory, anti-diarrhea, anti-amoebic, spasmolytic and antimalarial activities [4,5,6]. The presence of phytochemicals such as flavonoids, steroids, lignans, polyphenols, coumarins, terpenes and alkaloids in medicinal plants are scientifically proven to relieve inflammation, pain and fever. Several other reports have been made on medicinal plants with analgesic, anti-inflammatory and antidiabetic properties [7-10]. Baruah et al. [11] reported the insecticidal property of the T. diversifolia containing tagitinin A–C and F with tagitinin A. and isolation of some other chemicals such as diversifol, tithonine, and sulphurein. The tagitinin C, a sesquiterpene lactone from the plant has been reported to exhibit antiplasmodial activity and possessed cytotoxic properties in vitro [1].
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 ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CROTON SPARSIFLORUS MORONG LEAVES IN ANIMAL MODELS

 ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CROTON SPARSIFLORUS MORONG LEAVES IN ANIMAL MODELS

A depth study was carried out to find out the potential of chloroform extract of Croton (C) sparsiflorus morong. (Family-Euphorbiaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, C. Sparsiflorus Morong were extracted successively with petroleum ether (60-80°C)and chloroform in soxhlet apparatus.The chloroform extract (yield 5.60% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were put to investigate the effects of nociception, by the tail immersion and hot plate method on Swiss albino mice and anti inflammatory effect were studied by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral activity was carried out by elevated plus maze method in Swiss albino mice. Results shows that the CSCE has significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and also produced remarkable anti-inflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the CSCE has no differential anxiolysis effect when used orally. It concludes that, CSCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.
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Evaluation of anti inflammatory and gastric anti ulcer activity of Phyllanthus niruri L  (Euphorbiaceae) leaves in experimental rats

Evaluation of anti inflammatory and gastric anti ulcer activity of Phyllanthus niruri L (Euphorbiaceae) leaves in experimental rats

Female Swiss albino rats weighing 120-150 g were used in the experiment. Animals were housed in polypropyl- ene cages in groups of six per cage and were kept in a room maintained at 25 ± 2 °C with a 12 h light-dark cycle, and were allowed to acclimatize for one week before the experiment commenced. They were given free access to standard laboratory animal feed and water ad libitum. They were fasted over night before the experi- mental procedures began and all surgeries were performed under isoflurane (5% in 100% oxygen) anesthesia. The procedures were conducted with efforts to minimize preventable harm to the rats. Animal care and research protocols were centered on values and guidelines sanctioned by the Guide for the Care and Use of Laboratory Animals (NIH publication No: 85-23, revised in 1985). The prior approval for conducting the experiments on rats was obtained from the Departmental Ethics Committee of Dhaka University.
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Evaluation of Analgesic and Anti Inflammatory Activities on Ethanolic Extract of Terminalia chebula Fruits in Experimental Animal Models

Evaluation of Analgesic and Anti Inflammatory Activities on Ethanolic Extract of Terminalia chebula Fruits in Experimental Animal Models

Phytochemical studies of Terminalia chebula fruit ex- tract show the presence of tannins like chebulic acid, chebulagic acid, chebulinic acid, corilagin, gallic acid, gallotannins and ellagic acid; fructose, amino acids, suc- cinic acid, ascorbic acid, flavonol glycosides, triterpeno- ids, coumarin, betasitosterol, resin and anthroquinone [4,6]. The fruits of Terminalia chebula have been exten- sively used in Ayurvedic, Unani and Homoeopathic medicine. It is used in combination with Bahera in a herbal formulation called “Triphala” (three fruits) [4]. The dried ripe fruits have traditionally been used in the treatment of asthma, sore throat, vomiting, hiccup, bleed- ing piles, gout, heart and bladder diseases. Its paste with water is found to be anti-inflammatory, analgesic and has purifying and healing capacity for wounds [7]. It is given as adjuvant herb in chronic fever. It has been used to treat various ailments like hemorrhoids, dental caries, bleeding gums and oral ulcers, diarrhoea, gastroenteritis, malabsorption syndrome, vesicular and renal calculi, neuropathy, paralysis, memory loss, epilepsy, depression, diabetes, tumors, skin diseases, as well as intermittent fever, rheumatism, arthritis, gout, etc. [8,9]. The plant is reported to have antibacterial, antifungal, antiviral, anti- oxidant, hepatoprotective, cardioprotective, antidiabetic, hypolipidemic, antispasmodic, and various other activi- ties [4-7]. The present study was designed to investigate the analgesic and anti-inflammatory activities of the ethanolic fruits extract of the Terminalia chebula so as to provide a scientific proof for the activity.
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EVALUATION OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY EFFECT OF THE HYDROALCOHOLIC EXTRACTS OF LEAVES AND FRUIT PEEL OF P  GRANATUM IN EXPERIMENTAL ANIMALS

EVALUATION OF ANTINOCICEPTIVE AND ANTI INFLAMMATORY EFFECT OF THE HYDROALCOHOLIC EXTRACTS OF LEAVES AND FRUIT PEEL OF P GRANATUM IN EXPERIMENTAL ANIMALS

The antinociceptive activity of leaves and fruit peel of P. granatum was assessed using the acetic acid-induced writhing test in mice [12]. Control, Test and standard drug were given orally. After 60 minutes writhing was induced by intraperitoneal injection of 1% acetic acid in volume of 0.1 ml/10 g body weight. Group 1 received 1% Carboxyl methyl cellulose (CMC) as vehicle orally and was considered as control. Groups 2 and 3 received LEPG orally at a dose of 100 and 200 mg/kg respectively. Groups 4 and 5 received PEPG orally at a dose of 100 and 200 mg/kg respectively; Group 6 received Ibuprofen 100 mg/kg and served as the standard control. In all the groups, writhing episodes i.e. stretching movements consisting of arching of the back, elongation of body and extension of hind limbs were counted for 30 minutes. All the groups received the same volume of preparations. Antinociceptive activity was expressed as the percentage inhibition of abdominal constrictions between control animals and mice pre-treated (n=6) with the extract or standard drug using the ratio: (Control mean – Treated mean) /Control mean x 100
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ANTI INFLAMMATORY EVALUATION OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA L  (ASTERACEAE) IN EXPERIMENTAL ANIMAL MODELS FROM MOROCCO

ANTI INFLAMMATORY EVALUATION OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA L (ASTERACEAE) IN EXPERIMENTAL ANIMAL MODELS FROM MOROCCO

Matricaria chamomilla L. has been used in Moroccan traditional medicine to relieve pain, fever, inflammation. It is also used as a mild laxative and is antispasmodic, and bactericidal. The present study explored the anti-inflammatory potential of aqueous extract of Matricaria chamomilla L. (AEMC) (Asteraceae) in rodents, using standard laboratory models. This study was carried out by using female Swiss mice (25-30g) and Wistar male rats (180-220g).The aqueous extract was prepared by using maceration at room temperature (25°) over period 24 hours. The acute toxicity studies were carried out based on OECD guidelines 423. The LD50 of AEMC was found to be more than 2g/kg and did not produce mortality or changes in general behaviour of the test animals. The aqueous extract of MC was screened for it anti-inflammatory activity properties by using carrageenan and experimental trauma-induced hind paw oedema in rodents at 300 and 500 mg/kg. Indomethacin at 10 and 20 mg/kg was used as standard. From the results obtained the aqueous extract of Matricaria chamomilla L. showed significant activity comparable to the control and reference drug used in both models.
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Evaluation of the Analgesic and Antipyretic Actions of the Saraca Asoca Leaves in Experimental Animal Models

Evaluation of the Analgesic and Antipyretic Actions of the Saraca Asoca Leaves in Experimental Animal Models

The present study shows that Saraca asoca possesses analgesic activity on tail flick method. The tail flick model is an index that is used to evaluate acute pain in animals. Tail flick response is predominantly considered to be selective for centrally acting analgesic activity. The analgesic activity of Saraca asoca leaf extracts against acute inflammatory pain was compared to potent inhibitory activity of aspirin. Prostaglandin and bradykinin are important mediator in the pain process. Aspirin suppress the formation of pain substances in peripheral tissues and produced reduction in pain. Similar to Saraca asoca leaf extract suppress these substances and produces analgesic activity. [20, 21] From qualitative test presence of flavonoids in Saraca asoca leaves confirmed. Flavonoids inhibit the prostaglandin synthetase and prostaglandin show analgesic activity. In the present study, ethyl acetate extract (200 & 400 mg/kg) significantly increased the reaction time in tail flick method and shows significant analgesic activity. Similar to in antipyretic activity, fever may be as a result of infection or one of the sequelance of tissue damage, inflammation, graft rejection or other diseased states. Regulation of body temperature requires a delicate balance between the production and loss of heat. [22] Present study shows in Brewer’s yeast-induced pyrexia method the crude ethyl acetate extract at doses 200 mg/kg & 400 mg/kg produced marked antipyretic activity in Brewer’s yeast induced febrile rats. The reduction in the brewer’s yeast induced fever by the extract in this study suggests some influence on the prostaglandin in biosynthesis since it is responsible to be regulating of body temperature. [23]
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Anti-Inflammatory and Analgesic Activity of Leaves of Spilanthes Acmella (Elsa) in Experimental Animal Models

Anti-Inflammatory and Analgesic Activity of Leaves of Spilanthes Acmella (Elsa) in Experimental Animal Models

Th e anti -in flammato r y acti vit y against acut e in flam matio n was test ed b y carrageenan in du ced rat paw oedema m eth od 8 . Aft er ov erni ght fast in g acut e infl amm atio n was p rodu ced b y s ub -pl ant er inj ectio n o f 0.1 m l of freshl y p rep ared 1 % carrageen an su s pen sion in no rm al saline in th e l eft hind paw 9 o f rats in each gro up. Th e anim als were t reat ed wi th sin gl e do se o f resp ectiv e d ru g 1 h ou r b efo re carrageenan inj ectio n. Th e p aw vol um e was meas ured pleth ysmom etri call y 1 0 , ju s t befo re carrageen an i njectio n i .e. at ‘0 ’ho ur an d then at 3 r d h o ur after carrageen an injecti on. In creas e in paw ed em a was measu red as the di fference between th e two read in gs and th e p ercent age o f i nhi bitio n of p aw edema was cal cul at ed.
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ANTI-PSYCHOTIC EFFECT OF AQUEOUS LEAVES EXTRACT OF MORUS ALBA IN ANIMAL MODELS

ANTI-PSYCHOTIC EFFECT OF AQUEOUS LEAVES EXTRACT OF MORUS ALBA IN ANIMAL MODELS

Experimental Animals: Male Swiss albino mice (22-25g) and Male Wistar rats (160-180g) were used for the study. Animals were housed in a temperature (21± 2 0 C ) and light controlled room under a 12:12 h light dark cycle. Food and water were provided ad libitum. The experiment was carried out according to guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), New Delhi, India, and the Institutional Animal Ethical Committee (IAEC) approved protocol of this study.

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THE CONSTITUENTS AND PHARMACOLOGICAL PROPERTIES OF CALOTROPIS PROCERA - AN OVERVIEW

THE CONSTITUENTS AND PHARMACOLOGICAL PROPERTIES OF CALOTROPIS PROCERA - AN OVERVIEW

Calotropis procera is a soft-wooded, evergreen, perennial shrub. It has one or a few stems, few branches, and relatively few leaves, mostly concentrated near the growing tip. The bark is corky, furrowed, and light gray. A copious white sap flows whenever stems or leaves are cut. Giant milkweed has a very deep, stout taproot with few or no near-surface lateral roots. Giant milkweed roots were found to have few branches and reach depths of 1.7 to 3.0 m in Indian sandy desert soils. The opposite leaves are oblongobovate to nearly orbicular, short-pointed to blunt at the apex and have very short petioles below a nearly clasping, heart-shaped base. The leaf blades are light to dark green with nearly white veins. They are 7 to 18 cm long and 5 to 13 cm broad, slightly leathery, and have a fine coat of soft hairs that rub off. The flower clusters are umbelliform cymes that grow at or near the ends of twigs. The flowers are shallowly campanulate with five sepals that are 4 to 5 mm long, fleshy and variable in color from white to pink, often spotted or tinged with purple. The fruits are inflated, obliquely ovoid follicles that split and invert when mature to release flat, brown seeds with a tuft of white hairs at one end [50, 58-69].
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Anti-inflammatory and Anti-nociceptive activity of Rosa Canina aqueous extract in animal models

Anti-inflammatory and Anti-nociceptive activity of Rosa Canina aqueous extract in animal models

Several studies have shown in vitro the activity of Rosa canina extract on factors released in pain and inflammation. It is shown in a study that aqueous extract at concentration of 500µg/ml and higher can inhibit production of oxygen free radicals in PMNs and decrease chemotaxis in these cells [19]. Another study showed that a galactolipid as an active component is useful in reducing chemotaxis in PMNs [6]. In a study by Tanon and co-workers, Rosa hip and seeds’ extract couldn’t inhibit platelet activating factor-induced exocytosis of elastase and biosynthesis of prostaglandins[20].However, a short communication report showed that an organic solvent of rose hip extract can inhibit COX-1 and COX-2 in vitro. By the way, the aqueous extract was shown not to be effective in these studies[9]. In a cross- over trial, consumption of 45g of rose hip and seed powder over 28 days and consequent consumption of 10g of powder daily showed dose-dependent reduction of in-vitro chemotaxis of PMNs. In addition, markers of inflammation like C-reactive protein and creatinine decreased in this study [19].
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Antinociceptive, Anti-inflammatory and Antipyretic Effects of Aqueous Extracts of Morinda Lucida Leaves in Experimental Animals

Antinociceptive, Anti-inflammatory and Antipyretic Effects of Aqueous Extracts of Morinda Lucida Leaves in Experimental Animals

Morinda lucida Linn, (Rubiaceae) is a tropical plant indigenous to West Africa, has crown dense branchelets, slender leaves, with yellow wood when fresh and changes colour when exposed, and is used in folk medicine for various purposes. The antinociceptive, anti-inflammatory and antipyretic activities of aqueous extract of the leaves of Morinda lucida was studied using animal models. Results showed that the aqueous extract of M. lucida was devoid of severe toxicity (LD 50 986.6 ± 2.65 mg/kg body weight), raised the painthreshold in rats using the hotplate or thermal method, reduced drug- induced abdominal constrictions or algesic effect, reduced carrageenan-induced rat-paw oedema and demonstrated substantial antipyretic properties in vaccine-induced hyperthermia in rabbits. These results are comparable to standard non-steroidal anti-inflammary agent (acetylsalicylic acid). It is concluded that the aqueous extract of the leaves of M. lucida can demonstrate strong analgesic, anti-inflammatory and antipyretic potency comparable in a time and dose-dependent manner to a nonsteroidal anti- inflammatory drug.
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Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

Research Paper In-vitro evaluation of anti-inflammatory and anti-urolithiatic activity of Cichorium intybus leaves extract

Cichorium intybus commonly called as Chicory (Tamil name – Kasini), is an erect perennial herb belonging to the family Asteracea. Due to its prevalent distribution, different parts of the plant have been used in traditional medicines globally. Important phytochemicals that might have a positive effect in preventing many chronic diseases are distributed in the entire plant. Species belonging to the family Astereacea have been found to possess outstanding anti-inflammatory and anti- urolithiatic activities. From this hypothetical idea, an in-vitro experimental study was conducted using the leaves extract to treat urolithiasis and inflammation. In the current study, two different methods of extraction were carried out using the leaves of the plant C. intybus. The yield percentages of crude extract through maceration and from soxhlet extraction were 33 and 15.1%, respectively. The comparisons were made and the best method for extraction chosen. Further studies were carried out to test the plant extract for anti-inflammatory and anti- urolithiatic activity. The anti-inflammatory activity was studied using membrane stabilization activity and inhibition of albumin denaturation. The percentage inhibition of hemolysis obtained for membrane stabilization (49%) was compared against Aspirin (53%) used as the standard. The percentage Inhibition for albumin denaturation of C. intybus leaves extract (50%) was compared against Aspirin (55%) which was used as the standard. The results showed that the leaves of C. intybus plant possessed moderate anti-inflammatory activity. The C. intybus leaves showed good anti-urolithiatic activity against calcium oxalate and calcium phosphate stones. The percentage inhibition of mineralization of calcium oxalate stones (78%) were higher compared to calcium phosphate stones (75%). This study concludes the suitable method for the extraction of C. intybus plant. It also concludes that, the leaves extract effectively inhibit the progress of urolithiasis and inflammaiton and that it could be used as a prolific resource for drugs.
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Anti-Inflammatory and Anti-Nociceptive Activities of Heliotropium Indicum Linn. in Experimental Animal Models

Anti-Inflammatory and Anti-Nociceptive Activities of Heliotropium Indicum Linn. in Experimental Animal Models

Albino rats of Wistar strain (150 - 200 g) of both sexes and male Swiss albino mice (20 -25 g), were used to study the anti-inflammatory and anti-nociceptive activities, respectively. The animals were maintained under controlled room temperature (27°C ± 2) and relative humidity (60 - 70%) in a 12 h light-dark cycle, with free access to food and water ad libitum. The experimental procedures were carried out in strict compliance with the guidelines of the Institutional Animal Ethics Committee. Food was withdrawn 12 hrs before and during the experimental hours.
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ANTI – INFLAMMATORY ACTIVITY OF EXTRACTS OF WOODFORDIA FRUTICOSA STEMS BARK IN ANIMAL MODELS

ANTI – INFLAMMATORY ACTIVITY OF EXTRACTS OF WOODFORDIA FRUTICOSA STEMS BARK IN ANIMAL MODELS

Experimental Animals: 200-250gm Albino Wister rats were obtained from SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur; C.G. Animals were housed in groups of five in animal centre, Department of Pharmacy, at the room temperature of 25 ± 1 °C with free access to water and food. The study procedure was approved by IAEC (Institutional Animal Ethics Committee), Department of Pharmaceutical Sciences, G.G.V., Bilaspur, CG. Registration number is 994/a/Go/06/CPCSEA. For pharmacological screening of anti-inflammatory activity, albino rats were divided into six different groups. The first group served as a control group, second group was used as standard and the last four test groups which were received extracts of petroleum ether, chloroform, alcoholic and aqueous of Woodfordia fruticosa stems bark respectively at the dose of 200 mg/kg orally.
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