[PDF] Top 20 Evaluation of HER-2/neu status in Gastric Carcinoma

... with gastric carcinoma are tested for HER-2/neu and be given the benefit of ...test HER-2/neu ...of gastric cancer patients will have amplification of ... See full document

... In this study, c-Met protein expression was determined by IHC and scored by both membranous and cytoplasmic stain- ing. In our study, c-Met overexpression was 58.7% in 125 patients. The literature reports a difference in ... See full document

... in Gastric carcinoma has been variously reported as ranging from 18 to ...with gastric cancer, a few clinical trials have been performed with these drugs but with ambiguous ...of Gastric ... See full document

... Objective: HER-2/neu status in gastric carcinomas (GCs) has not been studied before in the Egyp- tian ...of HER-2/neu and Ki-67 using immunohistochemistry ...score ... See full document

... ductal carcinoma, avoiding foci of intraductal car- cinoma for which Her-2/neu has a different clinical signifi- ...of Her-2/neu gene amplification, and it can be used ... See full document

... Gastric carcinoma is the second common cause of cancer related worldwide ...The HER-2/neu is the Human epidermal growth factor receptor-2 and it is a gene localized on chromosome ... See full document

... Background: Gastric carcinoma is a deadly disease with high ...of gastric cancer has contributed to the development of rationally designed molecular targeted therapies which will improve the survival ... See full document

... that HER-2/neu over-expression correlates with reduced benefit of adjuvant therapy as in cases of carcinoma breast with tamoxifen ...of HER-2/neu suppresses the malignant ... See full document

... breast carcinoma was used as a positive ...a Her-2/neu rabbit monoclonal antibody (clone 4B5, using the Benchmark XT; Ventana Medical Systems) and detected by ultraview universal DAB detection ... See full document

... A role for CREB in the development of tumors has been suggested since it is often overexpressed and more active in many solid and hematopoietic tumors [23-26]. This could be influenced by the modulation of signalling ... See full document

... Immunohistochemistry was performed on formalin-fixed paraffin blocks which cut at a thickness of 2 μm. These sections were deparaffinized in xylene followed by hy- dration in a graded series of alcohols. Sections ... See full document

... node status, estrogen receptor (ER)/progesterone re- ceptor (PR) status, growth factor and its receptors, proliferation activity and DNA content with tumor suppressor genes and oncogenes ...breast ... See full document

... the evaluation of HER-2/neu expression is a typical example ...that HER-2/neu ampli- fication represents a prognostic and predictive marker; its expression is associated ... See full document

... The combinatorial treatment complicated our attempts to detect vaccine-induced Her2-specific anti- bodies in the vaccinated patients. However, a recently established l-subclass specific ELISA allowed evaluation of ... See full document

... breast carcinoma and presence of hormone receptor protein, no statistically significant difference has been found between ductal type and lobular type tumors ...breast carcinoma and those with ER—negative ... See full document

... of HER-2/neu marker was examined by immunohistochemical staining by Envision method using Hercep Test Kit (Dako, Denmark) according to manufacture's ...breast carcinoma with over- expression ... See full document

... the gastric volume was smaller, its anterior surface is normal and on the right side there is a close adhesion with the inferior left liver and perforated in the ... See full document

... In addition to new classes of cytotoxic agents, there is also interest in the use of oral fluorinated pyrimidines. These are FU prodrugs that offer the ease of oral administration and mimic the benefits of long-term ... See full document

... and HER-2/ ...the evaluation of hMLH1 and hMSH2, the dysplastic glands were regarded as negative only when stromal cells or lymphocytes in the adjacent area of dysplasia showed a positive nuclear ... See full document

... proto-oncogene HER-2/neu en- codes a 185-kD transmembrane glycoprotein with tyrosine kinase activity ...[5]. HER-2/neu over-expression typically oc- curs in the placenta, ... See full document