[PDF] Top 20 Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis

... sensitive biomarkers and prognostic indicators, a long preclinical phase, and lack of effective disease modifying ...ease neuroimaging initiative (ADNI, Jack et ...the Neuroimaging society in ALS ... See full document

... 2013, 'Mutant copper-zinc superoxide dismutase SOD1 induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron p[r] ... See full document

... multiple sclerosis a both of UMN and LMN involvement may be seen in the setting of plaque formation at root exit zones, combined with central nervous system (CNS) ...so neuroimaging may be essential in the ... See full document

... immunological evaluation 24 hours after cell engraftment reported sig- nificant reduction in activated lymphocytes and cytokine production, indicating immediate immunomodulatory effects of the hMSCs ... See full document

... Markers of inflammation and immune activation in CSF Inflammation in the CNS and the systemic circulation is considered to be a key factor in the pathogenesis of ALS [26, 27]. Inflammation in ALS is resulted from ... See full document

... intensive evaluation of multiple risk factors within clinical and population-based case-control studies of ALS, where many different types of information could be collected at the time of ... See full document

... in ALS patients and are recommended for patients with severe bulbar impairment (47,48). Nocturnal pulse oximetry, which involves measuring oxygen saturation throughout the night via transcutaneous finger probes (49), and ... See full document

... candidate biomarkers (summarised in panel 2),103, 104 and 105 the revised ALS functional rating score (ALSFRS-R; panel 3) is a frequently used outcome measure in therapeutic ... See full document

... ALS: Amyotrophic lateral sclerosis; ALSFRS: ALS functional rating scale; A β -42: Amyloid beta; BDNF: Brain-derived neurotrophic factor; FTD: Frontotemporal dementia; GFAP: Glial fibrillary acidic ... See full document

... Clinical TMS studies have given incredible insight into the time frame and regional involvement of inhibitory/excitatory disturbance in the cortex (Eisen et al 1993, Zanette et al 2002b, Vucic & Kiernan 2006b, Vucic ... See full document

... of Amyotrophic Lateral Sclerosis (ALS), an adult onset progressive fatal neurodegenerative ...ideal biomarkers may offer tools for rapid diagnosis, monitoring ... See full document

... We studied 21 consecutive patients with ALS who were recruited from Department of Neurology, Indira Gandhi Medical College, Shimla, Himachal Pradesh Patients with ALS (n = 21; women = 7; men = 14; mean age = 51.28 ± ... See full document

... We demonstrated that exosomal mRNAs can feasibly be biomarkers for diagnosis of ALS. CUEDC2 was the most dramatically increased exosomal mRNA in CSF from ALS patients. At least, inflammatory cytokines such as IL-6 ... See full document

... Neuroimaging studies of the head with magnetic res- onance imaging (MRI) and angiography (MRA), and brain regional perfusion as assessed by single photon emission computed tomography (SPECT) were per- formed for ... See full document

... establish biomarkers sensitive to diagnosis, prognostic stratification and disease activity of ALS (Table ...of amyotrophic lateral sclerosis (ALS) currently depends upon the opinion of an ... See full document

... Nevertheless, there are many remaining challenges. New techniques need to be harnessed and integrated into clinical research and practice. New acquisition schemes and analysis procedures require standardization and ... See full document

... (ALS): Amyotrophic lateral sclerosis; (UMN): upper motor neurone; (LMNs): lower motor neurone; (Ub-IR): ubiquitin-immunoreactive; (TDP43-IR): TDP-43 immu- noreactive; (EMG): electromyography; (PMA): ... See full document

... AD: Alzheimer ’ s disease; aFTLD-U: Atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions; ALS: Amyotrophic lateral sclerosis; ALS-FUS: Amyotrophic lateral sclero[r] ... See full document

... familial amyotrophic lateral sclerosis (ALS) has been associated with mutations in genes encoding Cu/Zn superoxide dismutase-1 (SOD1), TARDBP, and FUS ... See full document

... Some limitations of this study include the small sample size and the adherence evaluation and data collection methods. Using dispensing dates to evaluate adherence does not take into consideration other factors ... See full document