Top PDF Evaluation of anti-ulcer activity of Pluchea indica (L) Less in various ulcer models in rats

Evaluation of anti-ulcer activity of Pluchea indica (L) Less in various ulcer
models in rats

Evaluation of anti-ulcer activity of Pluchea indica (L) Less in various ulcer models in rats

the method of Hayden et al (24) with some modifi- cations. SD rats of either sex weighing between 170- 200 g were divided into 5 groups of 6 animals each and fasted for 24 hours with water ad libitum prior to experiment. The animal of group 1 were pretrea- ted with vehicle (1% CMC) and the animals of group 2 was treated with standard ie ranitidine 100 mg/kg . Similarly, the animals of group 3 and 4 were pretrea- ted with PIL at 40 and 160 mg/kg respectively. Indomethacin (30 mg/kg, p.o) was administered to all the animals of group 1-4, 60 minutes after the respective treatments. The animals were sacrificed by cervical dislocation after 6 hours of indometha- cin administration and stomach was incised along the greater curvature to determine the lesion damage. The percentage protection was calculated based on the total area lesion in treated group compared with the lesion in control group.
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Anti-ulcer Activity and HPTLC Analysis of Mangifera indica L. Leaves

Anti-ulcer Activity and HPTLC Analysis of Mangifera indica L. Leaves

roots 13 . This pharmacologically- active compound has been reported to have strong antioxidant 14 , anti lipid peroxidation, radioprotective 15 , immunomodulation 16 , anti-allergic 17 , anti-inflammatory and anti-nociceptive 18 , antitumour 19 , antidiabetic 20 , antidegenerative, wound healing, hypotensive, cardiotonic, lipolytic 21 , antibone resorption 22 , antiviral 23 , antibacterial 24 , antifungal 25 , antiparasitic 26 , monoamine oxidase-inhibiting activity 27 , hepatoprotective 28 and gastroprotective 29 activities. Various parts of the plant are used as a dentifrice, antiseptic, astringent, diaphoretic, stomachic, vermifuge, tonic, laxative and diuretic and to treat diarrhea, dysentery, anaemia, asthma, bronchitis, cough, hypertension, insomnia, rheumatism, toothache, leucorrhea, haemorrhage and piles. All parts are used to treat abscesses, broken horn, rabid dog or jackal bite, tumour, snakebite, stings, datura poisoning, heat stroke, miscarriage, anthrax, blisters, wounds in the mouth, tympanitis, colic, diarrhea, glossitis, indigestion, bacillosis, bloody dysentery, liver disorders, excessive urination and tetanus. Traditionally the plant is reported to have antiulcer activity 30 . In the present study, an effort has been made to establish the scientific validity to the antiulcer property of the leaves extracts of M. indica in aspirin induced ulcer in male albino rats.
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Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats

Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats

Aphanmixis polystachya (Amoora rohituka) is a large handsome evergreen tree, with a dense spreading crown and a straight cylindrical bole up to 15m in height and 1.5-1.8m in girth. The plant is distributed in the sub-Himalayan tract from Gonda (Uttar Pradesh) eastwards to Bengal, Sikkim and Assam. Upto 6000 ft. In Western Ghats, chota Nagpur, Konkarn, Andaman's and adjoining hill ranges from the Poona District southwards to Tinnevelly up to 3500 ft. As per the literature review of Aphanmixis polystachya stem bark various type of chemical constituents like aphanmixol, aphanmixin, amoorin, rohitukin, stigma 5, 24-diene-3-β-o-β- D glucopyranoyl-o-α-L rhamnopyranoside, poriferasterol -3- rhamnoside, dihydroamoorin, etc has been reported as active constituents which are responsible for various pharmacological actions like laxative, anthelmintic, antiulcer, antitumor, antimicrobial, antifungal, anti- inflammatory action, and traditionally it was used in liver and
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Evaluation of anti inflammatory and gastric anti ulcer activity of Phyllanthus niruri L  (Euphorbiaceae) leaves in experimental rats

Evaluation of anti inflammatory and gastric anti ulcer activity of Phyllanthus niruri L (Euphorbiaceae) leaves in experimental rats

Currently, various steroidal and non-steroidal anti- inflammatory drugs (NSAID) are being used to treat inflammatory diseases. Gastrointestinal bleeding and ulceration are the most recurrent and formidable prob- lems linked with NSAID [1]. Because of these side effects, researchers are in dire need to develop safer compounds. The gastric mucosal lesions caused by ethanol, were reported as by prying with the gastric de- fensive mechanisms [2]. While there are many products used against gastric ulcers, most of these drugs generate several adverse reactions [3]. To study the effects of drugs on the acute phase of inflammation, models were designed to induce inflammation in rat paws by injecting pro-inflammatory agents such as carrageenan, dextran, formaldehyde etc. [4]. Carrageenan-induced paw edema animal model is usually used to assess the contribution of natural products in weathering the biochemical changes associated with acute inflammation. While the carrageenan model is typically associated with activation of the cyclooxygenase pathway and is delicate to gluco- corticoids and prostaglandin synthesis antagonists, the early phase of the carrageenan reaction is due to the release of serotonin and histamine [5].
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Antiulcerogenic Activity of Alcoholic Extract of The Leaves of Tamarindus Indica (L) on Experimental Ulcer Models

Antiulcerogenic Activity of Alcoholic Extract of The Leaves of Tamarindus Indica (L) on Experimental Ulcer Models

. The results of the present study state that the ethanolic extract of TI has capacity to significantly (P>0.001) inhibit the basal gastric secretion and ulcerogenicity induced by pylorus ligation,indomethacin and cold restraint stress in rats as compared to control. Pylorus ligation(PL) induced ulcer occurs due to an increases in acid-pepsin accumulation due to pylorus obstruction and subsequence mucosal digestion [10]. Moreover, gastric acid is an important factor for the genesis of ulceration in pylorus- lighted rats [9]. The activation of the vagus-vagal reflux by stimulation of pressure receptors in the antral gastric mucosa in the hypersecretion model of ligature is believed to increase gastric acid secretion.
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Evaluation of the anti ulcer properties of aqueous leaf extract of Dialium guineense (Velvet Tamarind) on experimentally induced ulcer models in rats

Evaluation of the anti ulcer properties of aqueous leaf extract of Dialium guineense (Velvet Tamarind) on experimentally induced ulcer models in rats

1991; Deshpande et al., 2003). Therefore, agents that inhibit the effects of non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin will exhibit cytoprotection. The results obtained from using the indomethacin ulcer model showed that the extract can significantly inhibit the gastric effect of indomethacin (10mg/kg) and therefore further exhibiting cytoprotection. Generally, the activities of the extract may not be unconnected with the secretory effects of the extract. Since, gastric mucus production was significantly increased by the extract. Usually some substances like the NSAIDS produce gastric mucosal irritation in addition to various degrees of analgesic, anti-inflammatory and antipyretic effects (Neal, 1991; Steinmeyer, 2000). Leaves extract of D. guineense has been shown to contain phytochemical constituents like flavonoids which are capable of promoting gastric mucosal Table 1. Effects D. guineense aqueous leaf extract on ethanol/HCl- induced ulcers in rats
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EVALUATION OF ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS

EVALUATION OF ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS

ABSTRACT: Objective: Oecophylla smaradina (Formicidae) is an ant evaluated for its variety of medicinal uses. The objective of this study to evaluate the anti-ulcer activity using albino rats. Methods: The albino rats of either sex were divided into four groups. Ethanolic extract of Oecophylla smaradina (EEOS) was tested in the dose of 200 and 400 mg/kg p.o. respectively against by pylorus ligation induced ulcer models in albino rats. Results: Both the concentration (200 and 400 mg/kg p.o.) of extract have provided significant activity but EEOS 200 mg/kg, p.o, extracts were less effective when compared to EEOS 400 mg/kg, p.o. The antiulcer activity was accessed by evaluate the ulcer index in the test and standard drug treated group and also estimated the gastric volume, total acid, and free acid in the pylorus-ligated rats. Conclusion: The present study was revealed that ethanolic extract of Oecophylla smaradina have antiulcer activity.
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 ANTI – ULCER ACTIVITY OF POLYHERBAL FORMULATION – RO12 ON EXPERIMENTALLY INDUCED ULCER IN RATS

 ANTI – ULCER ACTIVITY OF POLYHERBAL FORMULATION – RO12 ON EXPERIMENTALLY INDUCED ULCER IN RATS

RO12, a polyherbal formulation, is a marketed drug which has been used in various gastrointestinal problems, however, there is no such clear documentation for antiulcer activity. So, the present study was carried out to test its antiulcer activity in rats using different models. Wistar rats were grouped into four, each group with 6 animals and injected with Normal Saline (control), Ranitidine 50 mg/kg (Standard drug), RO12 aqueous extract 200mg/kg and 400mg/kg (test drug) per orally in case of pylorus ligation model. In case of ethanol induced ulcer, misoprostol 10 mcg/kg was given as standard keeping everything else same as pylorus ligation method. Acute gastric ulceration in rats was produced by oral administration of ethanol and by pylorus‐ligated technique. The results showed that in both pylorus ligation and ethanol induced ulcer models, the aqueous extract RO12 exhibited significant decrease (P<0.001) in ulcer index, ulcer score, free acidity, total acidity, pepsin content in pylorus ligation induced ulcer as well as in ethanol induced ulcer models. This study demonstrated that, RO12 polyherbal formulation possess significant antiulcer activity. The aqueous extract of RO12 possesses dose dependent antiulcer effect. Current studies confirmed the claimed antiulcer activity in selected doses (200mg/kg and 400mg/kg).
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Evaluation of Anti-Ulcer Activity of Leaf Extract of Nelumbo Nucifera in Rats

Evaluation of Anti-Ulcer Activity of Leaf Extract of Nelumbo Nucifera in Rats

Nelumbo nucifera has long been used as a folk medicine in treatment of diarrhoea, fevers, bleeding and other inflammatory conditions. Therefore, the present study was designed to investigate the antiulcer effect of hydroalcoholic extract of leaves of Nelumbo nucifera. The hydroalcoholic leaf extract of Nelumbo nucifera was subjected to phytochemical screening which confirmed the presence of alkaloids, flavonoids, tannins, phytosterols and saponins. Acute gastric ulceration in rats was produced by oral administration of various noxious chemicals including indomethacin, ethanol, pylorus ligation technique and by subjecting the animals to cold restraint stress. The extract was administered in three different doses of 100, 200 and 400 mg/kg orally in all the experiments. The dose was calculated based upon acute toxicity studies. Ranitidine and Misoprostol were used as the standard drugs. The antiulcer activity was assessed by determining and comparing the ulcer index of the test group with that of the vehicle control group and standard group. The antiulcer potency was evaluated by determining and comparing the ulcer idex of the test group with that of the vehicle control group and standard group. The antiulcer activity was however less than the standard drugs. The above may be due to the presence of flavonoids, tannins and other phytoconstituents in the plant extract.
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ANTI ULCER ACTIVITY OF AQUEOUS EXTRACT OF ANNONA SQUAMOSA LEAVES ON RATS

ANTI ULCER ACTIVITY OF AQUEOUS EXTRACT OF ANNONA SQUAMOSA LEAVES ON RATS

The anti-ulcer activity of aqueous extract of Annona squamosa leaves was investigated on a indomethacin induced ulcer models in wistar rats. In model the common parameter determined was ulcer-index. aqueous extract of dosage 175, 350 mg/kg p.o produced significant inhibition of gastric lesions induced by indomethacin induced ulcers. The extract 175mg/kg & 350mg/kg showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicate that Annona squamosa leaves extract have potential anti ulcer activity. This results may further suggests that aqueous extract was found to posses antiulcerogenic as well as ulcer healing property,which might be anti secretory activity.
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 EVALUATION OF ANTIULCER ACTIVITY OF MANGIFERA INDICA KERNEL, VITAMINS AND ZINC SULPHATE ON PYLORUS LIGATION AND ETHANOL INDUCED ULCER MODELS IN RATS

 EVALUATION OF ANTIULCER ACTIVITY OF MANGIFERA INDICA KERNEL, VITAMINS AND ZINC SULPHATE ON PYLORUS LIGATION AND ETHANOL INDUCED ULCER MODELS IN RATS

In this method, albino rats were fasted in individual cages for 24 hr. Ethanolic extract of Mangifera indica/standard lansoprazole / Vitamin K/Vitamin C/Zinc sulphate administered 30 min prior to pyloric ligation. Under light ether anesthesia, the abdomen was opened and pylorus was ligated. The abdomen was then sutured. At the end of 6 hours after ligation the animals were sacrificed with excess of anesthetic ether. The stomach was dissected out, gastric juice was collected, were drained into tubes and centrifuged at 1000 rpm for 10 minutes and the volume was noted. Then the contents were subjected to analysis for free and total acidity. The stomach was then washed with running water to see ulcers in the glandular portion of the stomach. The number of ulcers per stomach was noted and severity of the ulcers scored microscopically with the help of hand lens (10X) and scoring was done as following.
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Evaluation Of Anti -Ulcer Activity of Alcoholic Extract of Hibiscus Rosa Sinesis In Rats.

Evaluation Of Anti -Ulcer Activity of Alcoholic Extract of Hibiscus Rosa Sinesis In Rats.

Albino rats weighing between (160-200 gm were divided into 8 groups of 6 rats in each. They were fasted in individual cages with measures taken to avoid coprophagy for 24 h prior to the experiment with free access to water. Group A was served as normal control given with vehicle only. Group B with standard drug, groups C, D, E were treated with low, medium and high doses of HAHR [7, 9]. The various groups were treated with vehicle/drug/ extracts 30 min prior to pylorus ligation and the details of the protocol was given below:
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Antiulcer Activity of Methanolic Extract of Leaf of Tylophora Indica on Histamine and Naproxen Induced Gastric Lesions in Rats

Antiulcer Activity of Methanolic Extract of Leaf of Tylophora Indica on Histamine and Naproxen Induced Gastric Lesions in Rats

infusion of root bark were used in dysentery, asthma, and bronchitis. The root juice of other species T. fasciculata is given in milk as tonic; the leaves are pounded and used as an application to unhealthy ulcers (3). Similarly leaf extracts of T. conspicua exhibits antiulcer activity on indomethacin induced gastric ulceration and gastric acid secretion in male albino rats (4). This plant already has been reported in the treatment of bronchial asthma and immunomodulatory activity, anti-diarrhoeal, anti-inflammatory, anti-arthritic and hepatoprotective (5-9). The different medicinal uses for T. indica in folk medicine stimulated an ethnopharmacological evaluation for anti-ulcer activity. There has been no systematic study until now to show the anti-ulcer activity of T. indica. Hence the objective of present study was to investigate anti-ulcer activity of T. indica leaf using histamine and naproxen induced ulcer in rat.
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Anti-ulcer potential of saponin fraction of Trichopus zeylanicus on a various experimental animal models

Anti-ulcer potential of saponin fraction of Trichopus zeylanicus on a various experimental animal models

Background: Trichopus zeylanicus Gaertn is a perennial herb, belongs to the family Trichopodaceae, is wild plant, a rare genus, small glabrous herb growing in the Agasthyar hilly forest of Kerala. The Kani tribes of this area call this plant as “Arogyapacha” or “Arokyapachilai” in Malayalam. Objective: The present study was investigated for anti-ulcer potential of Saponin fraction of the whole plant of T. zeylanicus on various experimental animal models. Materials and Methods: Acute toxicity study of saponin fraction of T. zeylanicus (SFTZ) was carried out on female albino rat up to 2000 mg/kg as per OECD guideline No.423. The experimental animal models, i.e., ethanol induced ulcer, restrained stress induced and pyloric ligation (PL) induced ulcers model were tested for anti-ulcer activity SFTZ at three various doses of (75,150 and 300 mg/kg, p.o.,) for 5 days to Wistar Albino rat. Esomeprazole (10 mg/kg, p.o.,) was used as a reference standard for the present study. Results: Treatment of SFTZ (75,150 and 300 mg/kg, p.o.,) showed a significant dose-dependent effect in lowering ulcer index with significantly increased in percentage protection against ethanol, restrained stress and PL induced ulcer model in rats. Biochemical parameter like gastric volume, pH, free acidity, total acidity total proteins, total hexoses, hexosamine, fucose, sialic acid, and pepsin were determined in PL induce ulcer models. The result showed significantly increased in level of defensive mucin secretion in terms of total carbohydrates: Protein ratio after SFTZ treated rats in PL induce ulcer models. Conclusion: The action potential of SFTZ is positively found to be more active in alleviating the ulcer by chemical and physical induced models.
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IN VITRO EVALUATION OF ANTIULCER ACTIVITY OF MELIA AZEDARACH LINN LEAVES ON WISTAR ALBINO RATS

IN VITRO EVALUATION OF ANTIULCER ACTIVITY OF MELIA AZEDARACH LINN LEAVES ON WISTAR ALBINO RATS

In the present study, dried powder of leaves of M. azedarach were subjected to extraction using 70%v/v alcohol and chloroform water I.P. Some part of both extracts was reserved for preliminary phytochemical investigation and rest was utilized for pharmacological screening. The preliminary phytochemical investigation showed presence of alkaloids, carbohydrates, glycosides, saponins, steroids and triterpenoids. The flavonoids being the major phytoconstituent was isolated from AlcE of leaves and subjected to qualitative TLC / HPTLC and FTIR analysis. It showed the presence of phenolic functional group in the glycoside. In FTIR spectrum of isolated flavonoids, the peak at 3684.68 cm-1 indicated the O-H stretching. UV spectra are supporting the results. However, further detailed study is necessary. The pharmacological screening included evaluation of antiurolithiatic activity using 0.75% ethylene glycol induced urolithiasis model in male Wistar albino rats. The kidney stone formation induced in rats, as a result of 14 days chronic administration of 0.75% ethylene glycol, was significantly inhibited by oral administration of AqE and AlcE of M. azedarach leaves. On prophylactic treatment, AqE and AlcE of M. azedarach leaves prevented the urinary stone formation. The study was extended to evaluate the antiulcer activity of M. azedarach leaves using Aspirin induced ulceration and Pylorus-ligation model in Wistar albino rats. AqE of M. azedarach leaves exhibited significant protection against Aspirin induced ulceration and Pylorus-ligation method as compared to standard drug Omeprazole.
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ANTI  ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS VIRGINIANA IN RATS

ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS VIRGINIANA IN RATS

Diospyros virginiana is a persimmon species commonly called the American Persimmon, Common Persimmon, Eastern Persimmon, "'Simmon", "Possumwood", or "Sugar-plum". This is a well-known indigenous trees [5] , growing in woods and fields. The parts of the D.virginiana have a long history of use in the new world. Persimmon have been used medicinally as an astringent and antiseptic and for the treatment of uterine hemorrhage, diarrhea and dysentery, diphtheria, dropsy, fevers, gonorrhea, hemorrhoids, syphilis and thrush. Persimmons have been used to lubricate the lungs and strengthen the spleen and pancreas. They improve energy and contain enzymes that help damaged cells and foreign microbes be broken down. Persimmons have a special affinity for the large intestines and heart. [6] Persimmons have been also used to treat bronchitis, catarrh, cough, , goiter, hangover and hiccoughs. The bark has been used in intermittent and both it and the unripe fruit have been beneficial in various forms of disease of the bowels, chronic dysentery, and uterine hemorrhage; used in infusion, syrup, or vinous tincture. [7] This study reports the antiulcer activity of leaf and bark ethanolic extracts of Diospyros virginiana using experimental models in rats.
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GASTRO PROTECTIVE ACTIVITY OF LEAVES OF MANGIFERA INDICA IN ULCER INDUCED ALBINO RATS

GASTRO PROTECTIVE ACTIVITY OF LEAVES OF MANGIFERA INDICA IN ULCER INDUCED ALBINO RATS

From the present study, it was concluded that the ethanolic and aqueous extract of leaves of Mangifera indica exhibited remarkable gastro-protective activity in pylorus ligation, aspirin plus pylorus ligation and ethanol induced gastric ulcer models. The results of the present investigation indicates that Mangifera indica may have equal extent of therapeutic effect (gastro-protective effect) with largely used well known anti gastric ulcer drug Ranitidine. Further studies are in progress to isolate the active constituent, the exact mechanism of gastro-protective activity and chances of teratogenicity.
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Evaluation of Anti-Ulcer Activity of Pithecellobium Dulce Seeds In Albino Wistar Strain Rats

Evaluation of Anti-Ulcer Activity of Pithecellobium Dulce Seeds In Albino Wistar Strain Rats

Pithecellobium dulce has been reported to exert several pharmacological properties such as antimicrobial, anti inflammatory, antibacterial, antioxidant, antidiabetic, hepatoprotective, activities. Despite claim of its potential in the treatment of gastric ulcer, this plant so for not been screened for anti-ulcer potential activity. Thus, we take this opportunity to report the preliminary findings on anti ulcer potential of Pithecellobiumdulce seed extracts for the first time here. The present study demonstrated the potential of EEPD and AEPD to significantly reduced gastric ulceration as indicated by the reduction in ulcer index in the pylorus induced assays. Based on further findings using the PL assay, the extracts was suggested to act by reducing the volume of gastric juice secreted, gastric free and total acidities. These results suggested that EEPD and AEPD possess anti-secretory potency as well s acid neutralizing effect. It is also possible to suggest that the observed antiulcer activity associated with P.dulce is the ability to exhibit antioxidant activity cited above. Oxidative stress, resulting from the increase production of oxygen derived free radicals (e.g. superoxide anion, hydrogen peroxide and hydroxyl radicals), has been known to take part in the pathogenesis of various diseases including gastric ulcer and antioxidants help to protect cells from damage elicited by oxidative stress while enhancing the body ’ s defence systems against degenerative diseases.
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EVALUATION OF ETHANOLIC EXTRACT OF ROOTS OF TRIANTHEMA TRIQUETRA FOR ANTI-ULCER ACTIVITY IN ALBINO RATS

EVALUATION OF ETHANOLIC EXTRACT OF ROOTS OF TRIANTHEMA TRIQUETRA FOR ANTI-ULCER ACTIVITY IN ALBINO RATS

Ulcer is an acute inflammatory lesion. It may be defined as the gradual destruction of the stomach, duodenum or both by acid gastric juice and is caused by disruptions of the gastric mucosal surface and repair system. [1] Peptic ulcer is an excoriated area of the gastric or duodenal mucosa caused by action of the gastric juice. It is a chronic and recurrent disease, and is the most predominant of the gastrointestinal diseases. Non-steroidal anti-inflammatory drugs (NSAIDS) such as indomethacin, aspirin and ibuprofen are know to cause gastric ulcer, especially when abused [2] Trianthema triquetra belonging to the family Aizoaceae is an annual herb which is traditionally used in indigenous medicine for gastric disorders and jaundice. Therefore the present study was conducted to evaluate anti-ulcer activity of Trianthema triquetra root on different ulcer models in albino rats. Due to the reported side effects of available antiulcer drugs, focus have been shifted towards natural products as the new sources of antiulcer agents. With the growing interest in natural medicine, various plants have been studied based on the traditional knowledge of their pharmacological properties and confirmed to be useful in treating and managing ulcer. [3] Furthermore, medicinal plants have been known to be amongst the most attractive sources of new drugs, and have been shown to give promising results in treatment of various diseases including gastric and duodenal ulcers. Trianthema triquetra root has been reported to show several pharmacological properties. This plant has so far not been screened for anti-ulcer activity.
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EVALUATION OF ANTIOXIDANT AND ANTI ULCER ACTIVITY OF SMILAX PERFOLIATA LINN

EVALUATION OF ANTIOXIDANT AND ANTI ULCER ACTIVITY OF SMILAX PERFOLIATA LINN

ABSTRACT: The leaves and fruits of Smilax perfoliata are traditionally used for treatment of various ailments such as rheumatism, lumbago, nourishing the functions of spleen, stomach, muscle and bone. The intent of the present study was to evaluate the antioxidant and anti-ulcer activity of ethanolic leaves and fruits extract of Smilax perfoliata Linn in albino rats. Gastric ulcers were induced by employing pylorus ligation method of induction. The anti-ulcer activity was analyzed by estimation of free acidity and the total acidity. The antioxidant potential was analyzed by method of DPPH free radical scavenging activity. The results obtained showed that the leaves and fruits of Smilax perfoliata possess antioxidant potential and are capable in the ministration of gastric ulcers.
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