[PDF] Top 20 Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... LAT transcripts can reactivate from explants of trigeminal ganglia derived from latently infected mice, with normal kinet- ...simian virus 40 RNA artificially ex- pressed in Xenopus laevis oocytes ... See full document
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Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
... gene transcripts were detected in cells treated with phosphonoacetic acid (400 m M) prior to infection with strain KOS(M) (data not shown) or in cells infected with IE175 (ICP4) deletion mutant KD6B11 (14, 44) ... See full document
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Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection.
... The PCR primers used were as follows: glyceraldehyde-3- phosphate dehydrogenase (GAPD) 357-bp product (sense, 5 9 - GAGGGGCCATCCACAGTCTTC-3 9 ; antisense, 5 9 -CATCA CCATCTTCCAGGAGCG-3 9 ); IP-10 431-bp product (sense, 5 ... See full document
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The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.
... HSV-1 latency-associated proteins have yet been convincingly demonstrated and antibodies raised against syn- thetic fragments of the LATs’ two ORFs did not identify pro- teins of the expected ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
... The LATs reduce ICP0, ICP4, and ICP27 mRNA levels in neuronal cell clones. To study the mechanism responsible for viral replication suppression by the LATs, we chose first to examine the influence of LATs on ICP0 gene ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... expression of cell cycle controller genes like EP300, P15, RBL1 and RBL2 were increased significantly, the cell cycle promoting genes like Mapk-1 indicated statistically significant decrease. The CyclinA2 ... See full document
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PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... Detection of latently infected neurons by means of in situ hybridization. In situ hybridization was performed with tissues from five mice per group and two mock-infected controls to detect ... See full document
12
Evidence for a Bidirectional Element Located Downstream from the Herpes Simplex Virus Type 1 Latency-Associated Promoter That Increases Its Activity during Latency
... hosts. Herpes simplex virus type 1 (HSV-1) establishes a latent infection in neurons of the peripheral nervous system in both their natural host, humans, and a variety of animal ... See full document
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A Virus with a Mutation in the ICP4-Binding Site in the L/ST Promoter of Herpes Simplex Virus Type 1, but Not a Virus with a Mutation in Open Reading Frame P, Exhibits Cell-Type-Specific Expression of γ134.5 Transcripts and Latency-Associated Transcripts
... using two genetic ...of two mutant vi- ruses: one, L/ST-n38, containing a nonsense mutation that terminates ORF-P translation at amino acid 38 but does not alter the sequence of ...wild-type ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... the virus establishes neuronal ...conclusive evidence is ...after latency had been established. Adeno-associated virus (AAV) vectors were used to deliver a ribozyme to target the ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... often associated with transcriptionally per- missive loci, and mapping the enrichment of acetyl-histone H3 has proved useful for mapping chromatin domains (7, 12, ...example, evidence suggests that in ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is restricted ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... infected trigeminal ganglia were identified by morphology and apoptotic neurons were counted (Fig. 4). Three independent experiments were performed, and approximately 1,000 neu- rons were identified and scored for ... See full document
7
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... allowing virus direct access to the nerves innervating the ...observed two different types of CGRP ⫹ FNEs. One type had a straight morphology (CGRP ⫹ long; ...second type had a short ... See full document
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Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts
... with herpes simplex virus type 1 (HSV-1) and HSV-2 is characterized by viral replication at the site of inoculation, followed by retrograde axonal transport of the virus ... See full document
7
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.
... None of the variants reported thus far contain a deletion that starts precisely at the 5' end of the 2.0-kb LAT or a deletion and/or insertion disrupting the putative ORF2 of 8071 Downlo[r] ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... In this study, a molecular genetic approach has been taken to map the reactivation phenotype within the primary LAT transcript. Using recombinants with an efficient polyadenyla- tion transcript termination signal ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...each virus are detailed in Fig. 1B. Wild-type McKrae and the marker-rescued viruses dLAT2903R and dLAT371R ... See full document
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Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... of latency, including the number of latently infected neu- rons and the number of viral genomes present in individual neurons, were ...of virus produced at 22 h pos- texplant and after hyperthermic stress ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... for two promoters capable of expressing LAT is unclear but might be explained on the basis of one possible LAT ...the virus in establishing latency. Once latency is estab- lished, LAP1 ... See full document
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