[PDF] Top 20 Evolution and Diversity in Human Herpes Simplex Virus Genomes

... a virus necessarily removes a variety of selection pressures and bottlenecks present in vivo and introduces new se- lection pressures unique to cell growth in ...for virus spread in humans (95–99, ... See full document

... and diversity, we created a high-throughput method for sequencing HSV from DNA swab and culture ...in human exome sequencing and oncology panels and for other herpesviruses ...HSV-2 genomes directly ... See full document

... of diversity among temporally distinct HSV-2 isolates from a single individual, and our data provide a context for future evolutionary and virulence studies, further investiga- tions of genome diversity ... See full document

... delivered herpes simplex virus genomes are subject to repression during the early stages of infection of human ...limit virus replication and lead to long-term persistence of ... See full document

... Hondo, and K. Nagashima. 1992. Detection of varicella-zoster virus DNA in human geniculate ganglia by polymerase chain reaction. J. Infect. Dis. 166: 1157–1159. FIG. 2. Copies of VZV, HSV-1, and HSV-2 genes ... See full document

... of herpes simplex virus to persist in cells depends on the extent of viral-gene expression, which may be controlled by epigenetic ...the human cytomegalovirus (HCMV) tk and gC promoters on the ... See full document

... from virus particles adsorbed to the cell surface during the initial stages of the ...viral genomes; and (iii) that they reflect an uncompacted status of the viral ...viral genomes are present in ... See full document

... recombinant virus expressed ␤ -galactosidase at day 10 ...resultant virus, in0123, was isolated and prop- agated on the complementing U2OS cell line SCP3, but un- fortunately, high-titer stocks could not be ... See full document

... HSV genomes in an experimental setting without seriously impacting the viral ...HSV genomes recovered from 4/8 uncultured buccal ...Epstein-Barr virus (EBV) genomes were readily recovered from ... See full document

... the virus and host lineages ...to human her- pesviruses than to other mammalian ...with human herpesviruses (2). Herpes simplex virus 2 (HSV-2) establishes a latent infection in ... See full document

... allow virus binding and were then moved to 37°C to allow virus ...Extracellular virus was inactivated by a low-pH buffer at the times indicated (orange ...viral genomes present was evaluated ... See full document

... viral genomes to both image, and purify replicating HSV-1 genomes for the identifi- cation of associated ...with genomes were the viral transcription factor ICP4 and the replication protein ...viral ... See full document

... a virus bearing the deletion of codons 400 to 420 of U L 15, encoding a terminase component, was ...This virus, designated vJB27, failed to replicate on noncomplementing cells but cleaved concatemeric DNA ... See full document

... Unlabeled purified nuclear RNA was isolated from cells at 45 min after infection and its sequences were compared to nuclear RNA labeled from 1 to 2 hr after infection by hybridization co[r] ... See full document

... discovered human herpesviruses, HHV-6 and HHV-7 have been associated with febrile illnesses and the childhood disease, exanthema ...This virus seems to resemble EBV in its possible oncogenic ...the ... See full document

... Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and the repl[r] ... See full document

... of herpes simplex virus type 1 (HSV-1) enter the cytosol by fusion of the viral envelopes with host cell membranes and use microtubules and microtubule motors for transport to the ...their ... See full document

... DISCUSSION We have examined the expression characteristics of a previ- ously described, HSV IE early gene mutant incapable of ex- pressing any of the five IE genes both in nonneuronal, cultured cell lines and in primary ... See full document

... We showed that the expression of a single protein, glycoprotein D (gD-l), specified by herpes simplex virus type 1 (HSV-1) renders cells resistant to infection by HSV but not to infectio[r] ... See full document

... Human embryonic lung (HEL) cells infected with human cytomegalovirus (HCMV) restricted the replication of herpes simplex virus type 1 (HSV-1).. A delay in HSV replication of 15 h as well[r] ... See full document