[PDF] Top 20 Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
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Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
... the evolutionary process of major histocompatibility complex (MHC) class I genes in ...18 class I genes are obtained and phylogenetically examined in ... See full document
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Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity
... the evolutionary time of divergence among species (Figure ...MHC genes (left pie chart); the nonclassical MHC-E and -F genes (center pie chart, representing ‘‘internal controls’’; ...MHC ... See full document
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Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells
... nonhuman primates before advancement to clinical ...in major histocompatibility (MHC) class I ...MHC class IA alleles, Mafa-A*25 and ...MHC class I alleles would be ... See full document
9
Efficient Class I Major Histocompatibility Complex Down-Regulation by Simian Immunodeficiency Virus Nef Is Associated with a Strong Selective Advantage in Infected Rhesus Macaques
... Point mutations in nef that disrupt important functions re- vert rapidly in infected animals (6, 20). Therefore, we analyzed the stability of the Y223F substitution in vivo. As shown in Fig. 4, Nef activity in ... See full document
5
Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication
... It is becoming increasingly clear that an individual’s HLA genes can affect the outcome of human immunodeficiency vi- rus (HIV) infection. Carrington et al. demonstrated that HLA- B*35 and -Cw*04 are present at a ... See full document
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... MHC class I molecules has not been ...-B genes, but not orthologues of HLA-C ...MHC class I haplotype ...MHC class I loci ... See full document
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Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys.
... MHC class I gene ...MHC class I genes as described by Watkins et ...MHC class I proteins were gen- erated by transcription from the T7 promoter and translation in the ... See full document
6
Transcriptionally Abundant Major Histocompatibility Complex Class I Alleles Are Fundamental to Nonhuman Primate Simian Immunodeficiency Virus-Specific CD8+ T Cell Responses
... is simian immunodeficiency virus (SIV)-infected nonhuman primates ...characterize major histocompatibility complex (MHC) class I ...MHC class I proteins are ... See full document
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Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus
... auxiliary genes found in simian immunode- ficiency virus (SIV) and human immunodeficiency virus ...env genes, nef is not essential for the ability of virus to ... See full document
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Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus.
... 57, 1986 class I glycoproteins encoded by genes of the K or DL loci of the murine major histocompatibility complex MHC 13, 27, simian virus 40-transformed cell lines 14 derived from the [r] ... See full document
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
... The expression pattern of MHC-I in cortical tubers of TSC patients resembled that observed in FCD II, with MHC-I positive blood vessels, neurons and microglial cells, but not astrocytes (Figure 3H,I ... See full document
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Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... Class I heavy chain expression in cells infected by these new mutant viruses was assayed in metabolic radiolabeling-immu- noprecipitation experiments ...postinfection; class I heavy chains ... See full document
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Polymorphism in regulatory gene sequences
... To what extent are polymorphisms in the regulatory regions subject to natural selection? They could in principle be neutral, transient (reflecting allele replacement or popula- tion mixing) or balanced (through increased ... See full document
6
A major histocompatibility complex class I related Fc receptor for IgG on rat hepatocytes
... a major histocompatibility complex (MHC) class I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral ...MHC class I transcripts, FcRn DNA was ... See full document
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Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
... MHC class I alleles. Up to 96 MHC class I cDNA clones from six pigtail macaques underwent forward and reverse sequencing, generating 700- to 1,000-bp ... See full document
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Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency
... 11 genes or their products between the HLA-DQB1 and the HLA-A ...or genes for both immunodeficiencies are located within the class III region of the MHC, possibly between the C4B and C2 ... See full document
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Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor.
... Second, SV40 does not bind to cells of two different human lymphoblastoid cell lines which do not express surface class I MHC proteins because of genetic defects in the 132-microglobulin[r] ... See full document
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Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
... MHC class I expression was measured with a conformationally dependent monoclonal antibody, ...MHC class I expression compared with PBLs from normal volunteers and non-insulin- dependent ... See full document
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Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey
... Total RNA and protein were extracted from cultured iPSCs using TRIzol Reagent (Thermo Fisher Scientific, Waltham, MA) and RAPI buffer (Thermo Fisher), respectively. RNA concentrations and purities were determined using a ... See full document
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Gene conversion in the evolution of both the H-2 and Qa class I genes of the murine major histocompatibility complex.
... For each putative conversion event we have analyzed the sequences and gene regions in- volved, the apparent length of the event, and its effect on protein sequence [r] ... See full document
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