[PDF] Top 20 An Exonic Splicing Silencer Downstream of the 3′ Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 Replication
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An Exonic Splicing Silencer Downstream of the 3′ Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 Replication
... pNL4- 3-transfected cells ...of virus production in pNEVM- and pNEU-transfected cells, demon- strating that decreased regulatory protein expression is not responsible for the observed defect in virus ... See full document
9
Repair of a Rev-Minus Human Immunodeficiency Virus Type 1 Mutant by Activation of a Cryptic Splice Site
... of replication-impaired HIV-1 mutants is a powerful genetic approach to dissect complex regulatory mech- anisms and to study nucleic acid and protein motifs that con- trol virus replication ... See full document
6
Regulation of vif mRNA Splicing by Human Immunodeficiency Virus Type 1 Requires 5′ Splice Site D2 and an Exonic Splicing Enhancer To Counteract Cellular Restriction Factor APOBEC3G
... ss downstream of the HIV-1 vif 3 ⬘ ss (5 ⬘ ss D2) and ESEVif exist in the HIV-1 genome to regulate the levels of vif mRNA and Vif protein in infected ...affect virus fitness in ... See full document
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Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription
... primer-binding site and 59 splice donor site, and we saw no differences in encapsidated RNA ...located downstream of the Gag initiating methio- nine (Fig. 8C). Wild-type, Dtat, or ... See full document
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A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus production.
... functional splice sites bordering exon 6D (4, ...mRNA splicing in HIV-1 strains lacking or con- taining exon 6D splice ...surrounding splice sites. In the viral context, activation of ... See full document
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Selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor.
... various splicing factors to both the 59 and 39 splice sites to form a ...in splice- osome assembly in vertebrates involves the recognition of the 5 9 splice site by the U1 small nuclear ... See full document
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Function of a Bovine Papillomavirus Type 1 Exonic Splicing Suppressor Requires a Suboptimal Upstream 3′ Splice Site
... Alternative splicing is an important mechanism for the regulation of bovine papillomavirus type 1 (BPV-1) gene expression during the virus life ...purine-rich exonic ... See full document
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Sequences Downstream of the 5′ Splice Donor Site Are Required for both Packaging and Dimerization of Human Immunodeficiency Virus Type 1 RNA
... of human immunodeficiency virus type 1 RNA are incorporated into each virus particle and are further converted to a stable dimer as the virus particle ...ⴕ splice ... See full document
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A suboptimal 5' splice site downstream of HIV 1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication
... increased splicing at HIV-1 3'ss A2 to show that increased splicing at HIV-1 3'ss A1 also disrupts virus ...Increased splicing at either 3'ss A1 or ... See full document
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RNA Splicing at Human Immunodeficiency Virus Type 1 3′ Splice Site A2 Is Regulated by Binding of hnRNP A/B Proteins to an Exonic Splicing Silencer Element
... the replication of other RNA viruses. Borna disease virus is a nonsegmented negative- strand RNA virus which replicates in the nucleus and whose RNA undergoes ...disease virus 3⬘ ... See full document
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Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication.
... between 1 22 and 1 24 by changing the A to U at 1 ...features required for TAR ...tween 1 22 and 1 24, gave rise to a revertant with a dinucle- otide transversion such that a ... See full document
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In Vitro Suppression of Human Immunodeficiency Virus Type 1 Replication by Measles Virus
... replicating virus (10, ...27), type 1/2 interferons (24), and the cytokines IL-10, IL-13, IL-16, and IL-18 (1, 2, ...HIV-1 replication by human her- pesvirus 6 has been ... See full document
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Opposite Effects of SDF-1 on Human Immunodeficiency Virus Type 1 Replication
... FIG. 3. Analysis of the effect of SDF-1 on cytosolic Gag p24 content and proviral DNA synthesis in target cells and on LTR ...for 1 h at 37°C. The cells were treated with pronase, to eliminate ... See full document
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Sustained Induction of NF-κB Is Required for Efficient Expression of Latent Human Immunodeficiency Virus Type 1
... for 1 or 6 h. Total RNA was extracted and initiated, and elongated HIV-1 mRNA transcripts were quantitated by real-time ...both 1 and 6 h after TNF- ␣ stimulation, whereas accumulation of elongated ... See full document
14
The I Domain Is Required for Efficient Plasma Membrane Binding of Human Immunodeficiency Virus Type 1 Pr55Gag
... not required for dense particle produc- ...which site-di- rected mutagenesis of conserved residues within the zinc finger domains of RSV and Moloney murine leukemia virus did not result in defects in ... See full document
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Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA
... usually required for efficient viral replication and expression, although recent reports sug- gest that transcription from nonintegrated HIV DNA appears to be a normal early step in HIV ... See full document
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Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3′ Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway
... 4. Splicing of the BPV-1 pre-mRNAs at the proximal 3⬘ splice site in cells lacking ASF/SF2 can be rescued by anti-IgM–B-cell receptor ...with 1 g of tetracycline per ml for 72 ... See full document
11
Role of the DIS hairpin in replication of human immunodeficiency virus type 1.
... FIG. 1. Models for HIV-1 RNA dimerization and ...unknown type of RNA-RNA interaction downstream of the ...the downstream DLS region (model ...motif downstream of the SD ... See full document
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Characterization of a Replication-Defective Human Immunodeficiency Virus Type 1 att Site Mutant That Is Blocked after the 3′ Processing Step of Retroviral Integration
... to replication-defective 604del ...wild type, 604del, and revE1 contained similar levels of unintegrated HIV-1 cDNA ...the 3⬘ ends of wild type, 604del, and revE1 were processed by ... See full document
6
Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
... recognition site for GalCer is located in the V3 loop of gp120 (47), although the C2 domain (amino acids 266 to 275) may also be involved ...is required for subse- quent interaction with the coreceptor ... See full document
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