[PDF] Top 20 Exosomes: biogenesis, biologic function and clinical potential

... that exosomes with a cell-specific cargo of proteins, lipids, and nucleic acids may act as a novel intercellular communication ...that exosomes released from parental cells may inter- act with target cells, ... See full document

... the biologic process underlying the differentiation of reticulocytes to mature ...secrete exosomes containing molecules that are essential for the adaptive immune response, specifically, dimers of the Major ... See full document

... so-called exosomes and microvesicles (EMVs) that are released via two distinct molecular mechanisms from a wide variety of tissue and blood cells into the circulation in response to normal and stress/pathogenic ... See full document

... It has been reported that blood cells and other organs can contribute to extracellular miRNAs. Pritchard et al. analyzed 79 solid tumor circulating miRNA biomarkers reported in the literature and found that 58% of them ... See full document

... coding function of circRNA, and that m 6 A-driven translation of circRNAs is potentially a general phenomenon, opens a new array of questions to reproductive physiologists: what are the function of these ... See full document

... cancer. Exosomes have been detected in many biological fluids, including urine, semen, saliva, amniotic fluid, cerebrospinal fluid, bile, ascites, tears, breast milk, and blood (2, 11, 37, ...Cancer ... See full document

... Emerging evidence has confirmed the vital paracrine effects of MSCs, especially secreted exosomes, for regu- lating osteocyte metabolism [79–81] (Fig. 2 (d)). Studies showed that the excessive production of ... See full document

... in exosomes: these miRNAs predominantly exist in the form of precursor miRNAs [28- ...outside exosomes, some researchers demonstrated that most circulating miRNAs from serum and saliva are in ... See full document

... Placenta-derived exosomes are synthesized by STB cells via the lysosomal pathway, whereby multivesicular bodies fuse with the cell membrane via exocytosis, resulting in the release of placental exosomes ... See full document

... in exosomes are present in a relatively independent special environment, having a high stability and abundance than tumor markers freely existed in tissues or body fluids, and therefore, possessing unique ... See full document

... and clinical studies have already proven exosomes to be an accessible and reliable source of biomarkers and early diagnosis of disease, with many more avenues yet to be ...explored. Exosomes bode ... See full document

... These findings were confirmed by Counchesne et al,m who reported normal brainstem auditory evoked potentials in all of the 10 non-mentally retarded autistic adolescents and young adults [r] ... See full document

... As previously mentioned, Aggarwal et al. studied the predictability of autoAbs for clinical improvement in pa- tients treated with BCD. His results indicated that auto- Abs, especially anti-synthetase (mainly ... See full document

... and biogenesis Because some mutations could prevent proper folding or insertion of newly synthesized ATPase into the endoplasmic reticulum membrane, the first step was to determine the relative amount of mutant ... See full document

... in exosomes by qPCR analyses, performed in vitro analyses and ELISA measurements, orthotopically injected cancer cells in mice, helped with the monitoring of in vivo experiments, designed the experimen- tal ... See full document

... CD45-containing exosomes from HIV-1 virion preparations ...of exosomes and HIV-1 virions produced from cells that express little or no ...exosome biogenesis in other HIV-1 target cells such as ... See full document

... Here we report three of eight patients (37.5%) with metastatic Ewing sarcoma who harbored germline mutations in the PTPRD gene. Using next-generation sequencing (NGS), two germline mutations were found in one patient, ... See full document

... Cell-cell communication can occur through various signaling molecules including chemical and electrical. Valadi et al. proposed that communication could also be mediated by exosomal RNA (mRNAs and microRNAs) [35]. ... See full document

... rOutiNe clinical prac- tice (ACTION) study aims to provide prospective, real- world data on abatacept retention in patients with RA and to identify predictors of abatacept ...recruited: biologic-naïve or ... See full document

... identify potential underly- ing mechanisms revealed that curcumin induced the expression of transcription factors (PPARc, GABPa, and TFAM) and coactivators (PGC1a) of mitochondrial bio- genesis in APOE3 ... See full document