[PDF] Top 20 Exploiting Population Samples to Enhance Genome-Wide Association Studies of Disease

... of population assumptions, to maxi- mize efficiency of association ...ous population data in a case–control study or using them naively to extend ...later studies employing standard analy- sis ... See full document

... of genome-wide association studies (GWAS) in population of Caucasian identified a single nucleotide polymorphism (SNP) rs17125944 in the FERMT2 gene as a new susceptibility locus for ... See full document

... the disease locus arise all the time, and (in homozygotes for recessive mutations, or heterozygotes for dominant mutations) cause ...The disease lowers an individual’s ability to survive and breed ... See full document

... case population consisted of 96 GSDs based in the UK, which were diagnosed with IBD at either the Royal Veterinary College (University of London, Uk), the Small Animal Teaching Hospital (University of Cambridge, ... See full document

... Crohn's disease. The ability of the Jewish population to maintain some power compared to the non-Jewish population could be explained by the higher prevalence of Crohn's disease observed in ... See full document

... conduct genome wide scale studies to find associations between disease phenotypes and genetic variants that may predispose to ...The studies typically use the new high-throughput ... See full document

... for population stratification in case-control studies was recently pro- posed by Epstein et ...of disease, given data on substruc- ture-informative ...of disease calculated using his or her ... See full document

... the disease of interest are compared to those in a disease-free group ...same population; (ii) isolation of DNA, genotyping and quality control measures to enrich the dataset; (iii) appropriate ... See full document

... general population cannot be adequately explained by these long QT syndrome ...general population, genome-wide association studies, in which up to one million single nucleotide ... See full document

... and association studies on a total of 32,642 subjects consisting of 4,043 LDD cases and 28,599 control ...strongest genome-wide linkage peak encompassed CHST3 from a Southern Chinese ... See full document

... with genome-wide significance for each ...and/or disease resistance will not affect ...immune, disease and production traits in indigenous village ... See full document

... A specific subset of the metabolome dealing with lipids termed lipidomics has provided important insights into how genetics contributes to modulated lipid levels. This area is of particular interest for cardiovascular ... See full document

... autoimmune disease characterized by inflammation of the synovial tissue and local articular ...damage. Studies of RA heritability in two European populations reported that 60% of the disease variance ... See full document

... a disease is usually a variant of a cross- sectional case-control study, the study design that is the familiar workhorse in biomedicine and epidemi- ology (Schlesselman, ...whole-genome association ... See full document

... landic population-based cohorts with 2,446 migraineurs and 8,534 non-migraineurs were ...cation samples derived from two population-based Dutch cohorts and one Australian Twin study totaling 2,957 ... See full document

... A majority of GWAS usually report only the most apparent molecular consequences of the sentinel variants, that is, SNPs in coding exons leading to amino-acid changes of the encoded proteins. Those typically represent ... See full document

... a genome-wide association analysis for a set of sampled and imputed SNPs with 16 conformation traits in a population of Mexican Holstein cows, revealed eight significant SNPs: one associated ... See full document

... GWAS: genome-wide association study; MLM: mixed linear models; OFA: Orthopedic Foundation for Animals; P3D: population parameter previously determined; PC: principal component; QTN: ... See full document

... A new algorithm was developed for the identification of large deletions. This takes into account paired-end reads mapping on the same chromosome but at a dis- tance that is incompatible with the expected insert size, and ... See full document

... the genome (Eyre-Walker 1993; Hwang and Green 2004; Singh et ...in studies on any ...in population genetics and experimental evolution studies (Atwell et ... See full document