[PDF] Top 20 Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents
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Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents
... (Figure 3) are not consistent with the α v β 3 integrin expression profiles obtained using FCM (Figure ...α v β 3 integrin was similar for both NCI-H157 and U251 cell ... See full document
9
Integrin α<sub>v</sub>β<sub>3</sub>-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy
... 10 minutes was predicted to achieve 50% cell kill with untar- geted NSs, a level that would allow comparison with agents that potentially increased the efficacy of thermoablation). With a 1.2 W 75% duty cycle, 808 ... See full document
11
A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes
... for integrin α v β ...MR imaging identified the heterogeneous distribution of α v β 3-positive tumor vessels by an irregular signal intensity decrease in HaCaT-ras-A-5RT3 xenografts, ... See full document
11
Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease
... these agents are certainly not contraindicated in these disorders as long as the clinician is aware of the relatively uncommon complication of worsening airflow ... See full document
9
Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway.
... The initial study assessed efficiency of gene transfer as a function of the differentiated state of the epithelium. Xeno- grafts were seeded at subconfluent density and explanted at subsequent times, approximating ... See full document
12
Cloning of the Xenopus integrin alpha(v) subunit and analysis of its distribution during early development
... Int J De, Hiol ~2 171 179 (1998) 171 Origil/al Arlirl,' Cloning of the Xenopus integrin CJ vsubunit and analysis of its distribution during early development THOMAS O JOOS", WOLFGANG E REINTSCH, ACHIM[.] ... See full document
9
Involvement of ROS alpha v beta 3 integrin FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
... α v β 3 integrin expression mediates the effect of melatonin on FAK and Pyk2 phosphorylation It is widely known that focal adhesion kinases are media- tors of the integrin pathway and that ... See full document
11
Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery.
... a v integrins (2, 23). Adenovirus interaction with a v integrins is mediated by an RGD sequence predicted to be located at the apex of a 10-Å (1-nm) protrusion on penton base protein (13, ... See full document
7
Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5
... Because incubation of asbestos fibers with serum increases their association with cells, we asked whether a protein coat on asbestos increased internalization of fibers via specific cellular receptors. Coating ... See full document
16
Multimodality Imaging of Integrin αvβ3 Expression
... molecular imaging modalities where typically the nanoparticle itself is detected, radionuclide-based imaging detects the radiolabel rather than the ... See full document
14
Nanobiomechanical Properties of Microtubules
... Modelling protein structures and studying their dynamic behaviours using computational methods and molecular dynamics simulation (MD) have been used in recent years [13]. MD simulations have become an important tool in ... See full document
6
Insulin like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
... a v b 5 to promote spontaneous pulmonary metastasis of multiple tumor cell types in both the chick embryo and se- vere combined immune deficiency mouse/human chimeric ...a v b 5 in tumor cells promoted ... See full document
10
Peptide secondary structure mimetics: The alpha helix and beta turn
... Despite its somewhat hindered nature, the amine component of this coupling should not prevent any real difficulties, so the problem must lie in the activation and reaction of the a-chloro ... See full document
229
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity
... of alpha v integrins on the tumorigenicity of human ...lack alpha v gene expression and thus fail to express integrin alpha v beta 3 (M21-L ...identical ... See full document
6
Small surfactant-like peptides can drive soluble proteins into active aggregates
... To study the generality of this short-peptide induced protein aggregation, in this work we set out to test a third type of small peptides, i.e., surfactant-like peptides that were designed to mimic surfactants and ... See full document
8
Estimates for the commutators of operator \(V^{\alpha }\nabla ( \Delta +V)^{ \beta }\)
... operator have appeared (see [1–5]). In recent years, some researchers have studied the boundedness of the commutators generated by the operators associated with L and the BMO type space (see [6–9]). In this paper, we ... See full document
18
Treatment of marrow stroma with interferon alpha restores normal beta 1 integrin dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors Role of MIP 1 alpha
... modulating beta 1 integrin receptor ...that alpha 4 beta 1 and alpha 5 beta 1 integrin receptors were involved in the enhanced adhesion of CML progenitors, suggesting that ... See full document
10
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin α<sub>v</sub>β<sub>3</sub> for staging liver fibrosis in rat model
... All experimental procedures were carried out in strict accor- dance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by ... See full document
12
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
... RGD-containing peptide, mAb 661 to vitronectin and mAb LM609 to integrin alpha v beta ...of alpha v beta 3 on the metastatic cells as compared to the parent ... See full document
9
Solid Phase Synthesis of Modular Peptide-based Targeted Molecular Imaging Agents
... The peptide was successfully synthesized by using the methodology developed as described in Chapter 3. Each step was carefully monitored by cleaving a tiny amount of the resin with 1 % TFA and assaying the ... See full document
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