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[PDF] Top 20 Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3

Has 10000 "Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3" found on our website. Below are the top 20 most common "Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3".

Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3

Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3

... of Sp1 or Sp3 within the specific DNA-protein complexes, we performed supershift experi- ments using Sp1- and Sp3-specific antibodies and anti-actin antibody (negative ...of Sp1 as well ... See full document

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The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3' to the TATA box.

The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3' to the TATA box.

... that Sp1 mainly bound to only one site in the LTRs (data not ...the Sp1 protein family seems to prefer the binding site located 3 9 to the TATA ...Both Sp1 and Sp3 stimulate ... See full document

11

Mechanisms of HERV-K (HML-2) Transcription during Human Mammary Epithelial Cell Transformation

Mechanisms of HERV-K (HML-2) Transcription during Human Mammary Epithelial Cell Transformation

... repetitive elements may play a role in host gene regulation, particularly through the donation of alternative promoters, enhancers, splice sites, and termination ...transcript expression of the ... See full document

16

Human-Specific Integrations of the HERV-K Endogenous Retrovirus Family

Human-Specific Integrations of the HERV-K Endogenous Retrovirus Family

... Human endogenous retroviral (HERV) elements comprise 1 to 2% of human DNA (26), but their biological relevance is largely ...the HERV-K (K denoting a lysine ... See full document

6

Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

... main HML-2 clade that integrated in the last 5 million years, ...also human-specific but are old and were copied by segmental ...conserved HML-2 env sequence was con- structed manually ... See full document

15

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

... mammalian expression vectors. Plasmid CEx30 harboring the complete HERV-K env gene was created by cloning a PCR-amplified fragment of pcE12env into the HindIII site of pRc-CMV (Invitrogen) downstream ... See full document

10

Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K–Related Sequences

Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K–Related Sequences

... the human genome (52, 53); molecular recombination among present-day HK2 proviruses produced viruses competent to replicate, providing proof of principle of the possibility of HK2 replication in ancient and ... See full document

15

Human endogenous retrovirus HERV K(HML 2) encodes a stable signal peptide with biological properties distinct from Rec

Human endogenous retrovirus HERV K(HML 2) encodes a stable signal peptide with biological properties distinct from Rec

... that HML-2 SP and Rec may have distinct biological ...Figure 2) was not ...transfected human cells with untransfected mouse ...GFPcORF expression plasmids and co-cul- tured with mouse ... See full document

20

Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription

Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription

... the human genome ...adult human tissues by epigenetic mechanisms such as DNA methylation or chromatin modifications ...of HERV transcription is possible under certain circumstances, and may ... See full document

7

Identification of an Active Reverse Transcriptase Enzyme Encoded by a Human Endogenous HERV-K Retrovirus

Identification of an Active Reverse Transcriptase Enzyme Encoded by a Human Endogenous HERV-K Retrovirus

... six HERV-K RT genes were uninterrupted, testifying to the apparent conservation of the RT open reading frame in this HERV-K ...complete HERV-K RT genes in hand, we set out to ... See full document

11

Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.

Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.

... Cloning, expression, and purification of HERV-K Gag and generation of ...full-length HERV-K gag cDNA clone (pcGU1; nucleotides [nt] 822 to 3626) was isolated from a randomly primed GH ... See full document

8

Expression pattern analysis of transcribed HERV sequences is complicated by ex vivorecombination

Expression pattern analysis of transcribed HERV sequences is complicated by ex vivorecombination

... one HML-2 provirus to an RNA tem- plate from another HML-2 provirus, forming a chimera between two different HML-2 ...another HML-2 provirus and were then ... See full document

12

Promoter expression of HERV K (HML 2) provirus derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Promoter expression of HERV K (HML 2) provirus derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

... ZR-75-1, MCF-7, T47D, SK-BR-3, Hcc1954, BT20, Hs578T, and MDA-MB-231 breast cancer cells were grown to 90% confluency. RNA was extracted and puri- fied using the RNeasy Mini Kit (Qiagen, Valencia, CA, USA, Cat. No. ... See full document

16

Vaccination directed against the human endogenous retrovirus K (HERV K) gag protein slows HERV K gag expressing cell growth in a murine model system

Vaccination directed against the human endogenous retrovirus K (HERV K) gag protein slows HERV K gag expressing cell growth in a murine model system

... Female specific pathogen-free 6–8-week-old BALB/c mice were purchased from Harlan. For tumor transplan- tations, RLZ-HKGag cells were grown to 60–80% con- fluence and detached from the culture dish via trypsin digestion. ... See full document

7

Staufen-1 Interacts with the Human Endogenous Retrovirus Family HERV-K(HML-2) Rec and Gag Proteins and Increases Virion Production

Staufen-1 Interacts with the Human Endogenous Retrovirus Family HERV-K(HML-2) Rec and Gag Proteins and Increases Virion Production

... the HERV-K113 5= UTR with the major splice donor site, a firefly luciferase gene, and the HERV-K113 gag and env genes with a splice acceptor site in env ...Rec expression from these constructs was ... See full document

12

A recurrent translocation is mediated by homologous recombination between HERV-H elements

A recurrent translocation is mediated by homologous recombination between HERV-H elements

... the HERV-Hs described here, is probably less frequent than NAHR between large seg- mental ...HERV15 elements that mediate the recurrent AZFa microdeletion leads to bet- ter sequence alignment between the ... See full document

8

Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus K (HERV K) in psoriasis

Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus K (HERV K) in psoriasis

... [11]. Human endogenous retroviruses (HERVs) might play a role in triggering these anti-viral immune responses, since the role of HERVs in the pathogenesis of autoimmune diseases has generated considerable ... See full document

8

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein

... differential expression determina- tion: ...known HERV-K (HML-2) genomes is available at the Markovitz laboratory website ...the human genome (hg19), and Cufflinks and Cuffdiff ... See full document

12

Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer

Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer

... retroviral elements make up approximately 8 percent of the human genome (33, 45), and they are generally considered to have lost the ability to replicate due to having acquired multiple ...functional ... See full document

8

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

... for expression in human cells [called HVif and Vp(h)u] and are further described elsewhere (Stephan Bour and Klaus Strebel, NIH AIDS Research and Reference Re- agent Program ...The HERV-K ... See full document

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