[PDF] Top 20 Bcl-2 expression predicts sensitivity to chemotherapy in breast cancer: a systematic review and meta-analysis

... I 2 = 100% × (Q - df )/Q. I 2 values of <25% may be considered "low", values of about 50% may be considered "moderate" and values of >75% maybe considered "high" ...performed ... See full document

... intention-to-treat analysis, sample size predefinition, loss of follow-up description, adverse events reports, and whether the trial was multicenter and/or ... See full document

... The extracted records retrieved by both of the databases will be merged and duplicates will be removed on the basis of title and year of publication using MS Excel 2007. In the first phase, two reviewers with experience ... See full document

... the cancer diagnosis was considered in this ...included cancer stage which was classified as either “local disease” (confined to the breast), “regional disease” (axillary lymph node involve- ment), ... See full document

... a meta-analysis based on previous studies and not on patient ...early breast cancer studies included in present study, and patients with metastatic breast cancer may have been ... See full document

... suitable chemotherapy scheme for the asso- ciation, which are the best molecular-targeted therapies, how to determine the ideal treatment sequence, and the real impact of using targeted therapy combined with CT in ... See full document

... tin expression and clinicopathological characteristics of breast cancer patients in this ...tin expression was correlated with ER negativity, PR negativity, high Ki-67 index, and positive p53 ... See full document

... to breast cancer has grown ...on breast cancer incidence, we conducted a systematic review and meta- analysis of randomized controlled trials comparing vitamin D ... See full document

... and chemotherapy (with result- ing premature ovarian failure) have improved survival for both ...in breast cancer ...and breast cancer survivors. We will perform a systematic ... See full document

... during breast reconstructions is not very uncommon, and IMN status can also be determined by fine-needle as- piration or core biopsy or thoracic ...survival analysis cannot be per- formed and the impact of ... See full document

... to breast cancer formation and therapeutic ...other Bcl-2 family members, Mcl-1 has a short half-life and is highly regulated at the transcriptional, post-transcriptional, translational and ... See full document

... Rationale: Leptomeningeal metastasis (LM) is an important cause of mortality in patients with non-small cell lung cancer (NSCLC). As the symptoms of LM and its early clinical manifestations are nonspecific, early ... See full document

... 11 meta-analyses [21,23- ...in meta-analyses are found in our literature review without ...in breast, colon and prostate cancers with increased effects in patients with higher PA ...the ... See full document

... Data analysis required pre-analytic ...component analysis (PCA) applied to the 306 tumors and the genes of PAM50 signature [73] (Supplementary Figure ... See full document

... For immunohistochemistry (IHC) analysis, 3- μ m-thick formalin- fi xed paraf fi n-embedded sections were sub- mitted. Brie fl y, one representative section of the tissue was cut and placed on poly-L-lysine coated ... See full document

... Descriptive data are presented as absolute numbers and percentages, mean ± standard deviation – if normally distributed – or as median and range – if not normally dis- tributed. In the case of continuous parameters, a ... See full document

... for systematic reviews and primary research from 1990 in August 2011 using several sources, including specialist registers [Cochrane Database of Systematic Reviews (CDSR), The Campbell Library, Database of ... See full document

... colorectal cancer in passing [26–28], yet their results in this regard had limita- tions because of the lack of in-depth ...colorectal cancer, but they only included two papers and used OR value to evaluate ... See full document

... the breast, pCR definition was still somewhat different compared to some studies that included in situ contents and some that did ...Adjuvant chemotherapy was adminis- tered to some patients, especially ... See full document

... Contrary to expectation, manipulation and mobilisation produce short-term increases in SNS outflow. In a review of the autonomic effects of spinal mobilisation, Kingston et al. [154] concluded that mobilisation ... See full document