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PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28–8 and E1L3N)
... quantitative comparison of PD-L1 IHC results obtained using three commercial antibody clones (SP142, 28–8 and E1L3N) in ...of PD-L1 expression on stromal or ... See full document
10
Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors
... ligand-1, PD-L1) expression in formalin-fixed paraffin-embedded (FFPE) samples have been developed as companion and complementary diag- nostics alongside immune checkpoint inhibitors (ICIs) targeting ... See full document
11
Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma
... a retrospective review of data from 170 patients who had undergone pulmonary resection as an initial treatment for clinical T1-2 N0 lung ...of three biomarkers using immunohistochemical analyses and ... See full document
10
Prognostic significance of PD-L1 expression in patients with gastric cancer in East Asia: a meta-analysis<div><br /></div><div><br /></div>
... ferent antibody source, type, or ...the PD-L1-negative group when mouse antibodies were used as primary anti-PD-L1 antibodies (HR ...all PD-L1-negative patients presented ... See full document
6
Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1
... of PD-L1 expression [8, 9]. Many different clones of PD-L1 antibodies have been tested in different tumors, in academic studies or clinical trials, as on different ... See full document
12
Clinical applications of PD-L1 bioassays for cancer immunotherapy
... in cancer therapy [1 – ...lung cancer as well as a variety of cancer types [4 – 10]. PD-L1 expres- sion varies due to the dynamic tumor microenvironment [11 – ...whether ... See full document
6
Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
... of PD-L1 and the mechanism of inhibition of PD-L1/PD-1 ...The PD-L1 homodimer distantly resembles that of PD-1/ PD-L1 (both proteins are characterized ... See full document
13
Modulating PD-L1 expression in multiple myeloma: an alternative strategy to target the PD-1/PD-L1 pathway
... selective expression in plasma cells, BCMA has gained interest as a target for chimeric antigen receptor (CAR) T cell ...BCMA expression by IHC or flow cytometry demonstrated antimyeloma activity, with ... See full document
16
PD-L1 expression in human cancers and its association with clinical outcomes
... lung cancer; RFS, relapse-free survival; VPSI, visceral pleural surface invasion; OS, overall survival; TNM, tumor–node–metastasis; CRC, colorectal cancer; mAb, monoclonal antibody; MMR, mismatch ... See full document
17
Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
... of PD-1- and PD-L1-targeting radiotracers could benefit many cancer ...of PD-1 and/or PD-L1 in the tumor environment using molecular imaging is predictive for the therapy ... See full document
12
Expression of PD L1 in triple negative breast cancer based on different immunohistochemical antibodies
... primary antibody incubation times and concentrations were determined by serial dilution for each immunohistochemical assay using a tissue block fixed and embedded exactly as for the ... See full document
12
PD1/PDL-1 Inhibitors: Emerging Hope for Bladder Cancer
... subtypes are more significant in luminal type II. Higher mutational load in responders and those with long survival suggested mutation load positive correlation with better response and survival. Grade 3-4 TRAEs occurred ... See full document
10
Immunotherapy in Merkel cell carcinoma: role of Avelumab
... Treatment for localized MCC includes surgery with or without radiation therapy. The cure rates are as high as 95%, but more than half of these patients later have recurrence, commonly with distant disease. Metastatic MCC ... See full document
5
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma
... CTLA-4, PD-1/PD-L1, with small molecule inhibitors of indolamine deoxygenase (IDO), have also been shown to lead to improved tumor control and in- creased IL-2 production by tumor infiltrating ... See full document
11
Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies
... in gastric carcinomas correlated with microsatellite repeats which are vulnerable to DNA damage, one of the samples which has the 118 integration breakpoints, the whole-exome sequencing showed the mutation ... See full document
10
HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1
... different cancer types on the correlations between im- mune cell infiltration and HHLA2 ...HHLA2 expression was independently corre- lated with high TIL infiltration ...HHLA2 expression and the ... See full document
11
Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors
... targeting PD-L1 immuno- therapy in ...with PD-L1 expression, which indicates an adaptive immune resistance-type mech- anism that can also be observed in ...the PD-L1 ... See full document
10
Original Article Programmed death ligand 1 expression in bladder rhabdomyosarcoma and its association with clinicopathological features
... evaluate PD-L1 expression in bladder RMS and assess its effect on patient clinico- pathological features and survival ...that PD-L1 expression tended to associate with tumor ... See full document
6
PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
... against cancer cells [7-9]. Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface of activated T-cells, as well as on B-cells and natural killers (NK) [10], binding its ... See full document
10
<p>Prognostic Significance of PD-L1 Expression and Its Tumor-Intrinsic Functions in Hypopharyngeal Squamous Cell Carcinoma</p>
... Methods: PD-L1 expression in HSCC tumor tissues and paired adjacent hypopharyngeal mucosal tissues was detected using immunohistochemistry assay, and the clinical signi fi cance of PD-L1 ... See full document
10
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