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[PDF] Top 20 Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

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Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

... The intervertebral disc (IVD) is composed of a central gel- atinous nucleus pulposus (NP), a peripherally located an- nulus fibrosus (AF), and the cranial and caudal cartilaginous endplates associated with ... See full document

13

RANK/RANKL/OPG system in the intervertebral disc.

RANK/RANKL/OPG system in the intervertebral disc.

... of RANKL on matrix metabolism, rat IVD cells were treated with exogenous ...gene expression of catabolic molecules, such as IL-1β, MMP-3 and MMP-13 by both rat AF and NP cells was not stimulated by ... See full document

11

RANK/RANKL/OPG system in the intervertebral disc

RANK/RANKL/OPG system in the intervertebral disc

... 8]. RANKL and its receptor (RANK) have been shown to play crucial roles in osteoclast differentiation and ...of RANKL to RANK activates TNF receptor-associated fac- tor (TRAF) 6, which ... See full document

10

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration

... adult intervertebral disc has little or no direct vasculature supplying it, particularly the central nucleus pulposus (NP) [13], where cell death is reported to be most common ...the intervertebral ... See full document

8

Increased caveolin 1 in intervertebral disc degeneration facilitates repair

Increased caveolin 1 in intervertebral disc degeneration facilitates repair

... the expression of the antiapoptosis protein survivin [46, ...and human IVDs, caveolin-1 expression [16] and apoptosis levels were positively correlated with IVD de- generation ...caveolin-1 ... See full document

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Lumbar intervertebral disc degeneration and related factors in Korean firefighters

Lumbar intervertebral disc degeneration and related factors in Korean firefighters

... The design of the study was cross-sectional. We selected subjects using a strati fi ed random sampling method in order to improve the representativeness of the subjects. Initially, 25 fi re stations were randomly sampled ... See full document

6

INTERVERTEBRAL DISC PATHOLOGY AND AYURVEDA .......

INTERVERTEBRAL DISC PATHOLOGY AND AYURVEDA .......

... (especially intervertebral disc), it leads to sandhigata ...of intervertebral disc pathology is ...the disc are the commonest ... See full document

10

Original Article Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration

Original Article Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration

... of Intervertebral disc degeneration (IVDD) is also companied by uncurbed inflammation, many cytokines were reported presenting in the ...degenerative intervertebral disc (IVD) is ... See full document

7

Original Article RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration

Original Article RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration

... in intervertebral disc degeneration ...RASSF7 expression level in human degenerative nucleus pulposus (NP) cells and non-degenerative NP cells and the link between RASSF7-JNK with NP ... See full document

7

Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc

Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc

... Introduction: Intervertebral disc (IVD) degeneration is considered a major underlying factor in the pathogenesis of chronic low back ...during degeneration there is ingrowth of ... See full document

11

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

... and disc height into canine, porcine and rabbit models ...degenerated intervertebral disc re- sulted in deceleration of disc height loss and increase in T2-weighted signal inten- ...and ... See full document

10

MRI AND DISCOGRAPHY OF ANNULAR TEARS AND INTERVERTEBRAL DISC DEGENERATION

MRI AND DISCOGRAPHY OF ANNULAR TEARS AND INTERVERTEBRAL DISC DEGENERATION

... Most normal discs accepted a high intradiscal pressure with no pain, but three of the nine discograms with a low pressure reproduced the patients’ typical pain. MRI is now an alternative[r] ... See full document

5

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

... as human cartilage and bone, and, interestingly, recent studies have highlighted a possible role for neurotrophins in the IVD [14- ...degenerate disc cells, mediators they hypothesised to be neu- rotrophic ... See full document

9

A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine

A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine

... lumbar disc degeneration, Pfirrmann’s classification (2001) [8] was endorsed as a valid and re- liable method of assessing the intervertebral disc degener- ation using MRI ...assessing ... See full document

6

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

... several colours can be compared to changes in the win- dow level. On the one hand, changing the window level can provide more detailed information by creating a better contrast of the annulus fibrosus and nucleus ... See full document

7

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities

... having already demonstrated its non-angiogenic potential, as well as providing an optimal environment for chondro- cyte culturing, both in vitro and in vivo. Collagen II, as a more expensive alternative to ... See full document

19

Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging

Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging

... short, eight skeletally mature female Dutch milk goats were obtained from a local farmer. During a surgical procedure three out of six lumbar IVDs in each goat were injected with chondroitinase ABC (CABC), an enzyme ... See full document

23

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration

... IVD degeneration (grade II) showed an increase rather than a decrease in bone volume or ...IVD degeneration 31,32 ...IVD degeneration, the entire IVD is replaced by nonfunctional fibrous scar ... See full document

7

The biology behind the human intervertebral disc and its endplates

The biology behind the human intervertebral disc and its endplates

... (B) intervertebral discs (IVDs), as well as the origin of sensory nerve fibres that innervate ...of expression of receptors for neurotrophic factors, pattern of expression of different ion channels ... See full document

12

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

... IVD degeneration is characterized by the reduction of water content and ECM ...this degeneration represents a loss of steady-state metabol- ism that probably results from an imbalance between anabolic and ... See full document

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