[PDF] Top 20 MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients
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MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients
... metastatic clear cell Renal Cell Carcinoma (ccRCC), but the majority of patients show disease progression after first line therapy with a very low rate of complete or long-term ... See full document
15
Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma
... of tyrosine- kinase inhibitors (TKIs) have been developed that seek to target VEGF signaling in ...metastatic renal cell carcinoma (mRCC) ...mRCC patients who had used interferon ... See full document
5
Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma.
... between clear cell renal car- cinoma (ccRCC) primary tumours and metastases ...neous response and progression patterns of different metas- tases within individual patients during ... See full document
9
Chromophobe renal cell carcinoma with prolonged response to targeted therapy: a case report
... RCC treatment has been classically derived from clinical trials that incorporated all histologies comprising clear cell, papillary, chromophobe, and other rarer ...in patients with ... See full document
5
Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma
... Renal cell carcinoma (RCC) accounts for 2–3% of all malignant tumors in adults, and clear cell renal cell carcinoma (ccRCC) is one of the most frequent RCC subtypes ... See full document
10
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma
... treating clear cell RCC. Patients with RCC response to postoperative adjuvant chemotherapy at various levels and usually cannot achieve expected outcomes ...of cell proliferation, ... See full document
9
Identification of clear cell renal cell carcinoma and oncocytoma using a three gene promoter methylation panel
... The differential diagnosis among specific RCT subtypes can be challenging, especially in those tumors composed of cells with granular eosinophilic cytoplasm, as some morphological and immunohistochemical overlap exists ... See full document
9
Original Article MiR-212 suppressed the metastases of non-small cell lung cancer by reducing ZEB2 expression
... of miR-212 significantly decreased in NSCLC specimens compared to the adjacent non-tumor ...that miR-212 might target and regulate ZEB2 in NSCLC ...of miR-212 in NSCLC tissues were inversely ... See full document
7
Original Article Reduced expression of miR-506 in glioma is associated with advanced tumor progression and unfavorable prognosis
... using miR-506 specific ...The expression level of miR-506 was normalized internally by using the CT of ...of miR-506 expression with ... See full document
5
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
... The present population-based study represents one of the largest series to date that investigates the occurrence and role of PAI-1 in CCRCC. The PAI-1 expression was found to be significantly associated with ... See full document
5
Expression of KI67, P53 and MUC1 in Renal Cell Carcinoma in Correlation with Nuclear Grade
... of the independent prognostic marker for clear cell variety of RCCs. (121) The RCC-specific 5-year survival rate is 89% in case of grade 1 tumours, 65% in case of grade 2 tumours and 46% in case of grades ... See full document
174
Stereotactic body radiation therapy in combination with systemic therapy for metastatic renal cell carcinoma: a prospective multicentre study
... 17 patients were enrolled (14 men and 3 women, median age: ...primary renal cell carcinoma (RCC) (n=1) and locally recurrent RCC ...Radiographic response in the target lesion was seen ... See full document
6
Somatic mutations in renal cell carcinomas from Chinese patients revealed by targeted gene panel sequencing and their associations with prognosis and PD-L1 expression
... the treatment of advanced RCC and other ...T cell activity in the tumor microenvironment, and inhibition of the PD-1/PD-L1 pathway can increase the anti-tumor immune response ...point ... See full document
6
<p>MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2</p>
... the expression of miR-935 in 25 paired ccRCC tissues and 3 RCC cell ...between miR-935 expression and clinicopathological parameters is shown in Table ...of miR-935 (Figure 1A ... See full document
10
Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy
... : renal cell carcinoma; ccRCC : clear cell renal cell carcinoma; mRCC : metastatic renal cell carcinoma; pRCC : papillary renal ... See full document
15
Original Article MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2
... promote cell proliferation ...tocellular carcinoma, which predicts poor prog- nosis of hepatocellular carcinoma, and pro- Figure ...of miR-485-5p in HCC cells. A. Prediction of ... See full document
8
Profile of panobinostat and its potential for treatment in solid tumors: an update
... pan-deacetylase inhibitor that is being evaluated in both intravenous and oral formulations across multiple tumor ...the expression of otherwise repressed genes, leading to inhibition of cellular ... See full document
12
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1
... Snail expression vector (Snail), the luciferase activity was effi- ciently repressed (Figure ...the expression level of miR-199a, which was consistent with the Northern blot assay (Figure ...the ... See full document
10
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma
... and cell cycle regulation, among other processes [25, ...in cell lines of ccRCC and clinical samples in which SETD2 has been demonstrated to function as a tumor suppressor gene in renal cell ... See full document
14
Identification of biomarkers of chromophobe renal cell carcinoma by weighted gene co-expression network analysis
... 4. Lee WK, Byun SS, Kim HH, Rha KH, Hwang TK, Sung GT, Lee W, Lim JS, Jeong YB, Kwon TG. Characteristics and prognosis of chromophobe non-metastatic renal cell carcinoma: a multicenter study. Int J ... See full document
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