[PDF] Top 20 Extracellular Matrix Regulates Fibroblast Heterogeneity And Tumorigenesis
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Extracellular Matrix Regulates Fibroblast Heterogeneity And Tumorigenesis
... activated fibroblast heterogeneity and ECM composition could be assayed by immunofluorescence staining for FAP, αSMA, FN, and COL1 in tumors and granulation ...ECM regulates fibroblast ... See full document
103
Fibroblast growth factor 2 regulates human cardiac myofibroblast mediated extracellular matrix remodeling
... Fibrosis is a complex phenomenon. The role of LMW- FGF-2 in mediating cardiac ECM regulation and fibrosis pathways is unclear. Selected prior studies suggest that cardiac FGF-2 expression is pro-fibrotic. Li and col- ... See full document
11
Fibroblast heterogeneity: implications for human disease
... the extracellular matrix of connective tissue and play an essential role in maintaining the structural integrity of most ...of fibroblast subtypes in mice. Here, we discuss fibroblast ... See full document
11
The role of integrins in mechano-transduction leading to enhanced collagen synthesis in human cardiac fibroblasts
... It regulates protein turnover, cell growth and cell ...the extracellular matrix of the heart and vasculature - it contributes to the functional integrity of the myocardium and blood vessel ... See full document
353
The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish
... function by MO (Heasman, 2002) knockdown experiments. We found that an MO designed to knock down the 124H4 clone caused heart malformations and subsequently determined that the 124H4 clone is identical to the previously ... See full document
10
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis
... Integrins are the main cellular receptors for ECM proteins and are important components of FA [58, 67]. In addition, CAV1 is important for integrin-dependent fibronectin adhesion and focal adhesion kinase (FAK) ... See full document
23
Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis
... The experimental set up of the study had some weak- nesses. First of all, the lack of a more clinically relevant matrix as a control was a major limitation. The ideal control material for the present study would ... See full document
9
Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes
... MMP1-3-13, matrix metallopep- tidases involved in extracellular matrix degradation; CCL2-5, chemokines recruiting innate immune cells such as lymphocytes and monocytes; IL-6 and CXCL8 (also named ... See full document
17
Regulation of TGF-Β1-Induced Apoptosis and Epithelial-Mesenchymal Transition by Matrix Rigidity
... collagen matrix and found a role for the discoidin domain receptors (DDR1 and 2) in FAK degradation (Bhadriraju et ...adhesive matrix, FAK degradation is likely regulated by a different ... See full document
118
Sulforaphane has opposing effects on TNF alpha stimulated and unstimulated synoviocytes
... ECM: extracellular matrix; ELISA: enzyme-linked immunosorbent assay; FCS: foetal calf serum; FLS: fibroblast-like synoviocytes; IL-1 β : interleukin-1beta; IL-6: interleukin-6; MMP: matrix ... See full document
10
Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method
... When directing feeder-free hPSC differentiation towards ocular epithelial lineages, suspension culture as EBs greatly improved cell survival, while small molecule induction helped direct differentiation. For feeder-free ... See full document
15
Expression of CD147 and matrix metalloproteinase 11 in colorectal cancer and their relationship to clinicopathological features
... the extracellular matrix (ECM) and some other ...cellular matrix component, instead, it catalyzes the deg- radation of serine protease inhibitors, a 1-antitrypsin and insulin-like growth factor ... See full document
11
Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration
... The microfluidic flow-focusing device is applied to cell encapsulation with various junction types. To control the generation of droplets, T-junction and flow-focusing methods can be applied according to the channel ... See full document
14
Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
... and extracellular matrix (ECM) degradation, endothelial cell proliferation, migration, tube formation and maturation into functional blood ...as matrix metalloproteinases, growth factors, enzymes, ... See full document
12
Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells
... After treatment with 17β-estradiol for 13 days in SMGS growth medium, pSMCs were washed twice with PBS and then cultured in serum-free medium 231 supple- mented with 0.2% w/v lactalbumin enzymatic hydrolys- ate (catalog ... See full document
16
Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture
... ECM: extracellular matrix; EGF: epidermal growth factor; ELISA: enzyme-linked immunosorbent assay; FB: fibroblasts; FGF-2: fibroblast growth factor-2 (or fibroblast growth factor basic/FGF- ... See full document
12
Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts
... target of the integrin signaling pathway [22, 23]. It has been reported that in the process of liver fibrosis, the protein and mRNA expression levels of Cygb increase progressively [24]. Normal overexpression of Cygb ... See full document
6
Current achievements and future perspectives in whole-organ bioengineering
... Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppressive ... See full document
12
Extracellular matrix and fibroblast injection produces pterygium-like lesion in rabbits
... All procedures were conducted according to the Guide for the Care and Use of Laboratory Animals and were approved by Institutional Animal Care and Use Com- mittee. A total of six 3-month-old white New Zealand rabbits ... See full document
7
Induction of chondrogenesis of human placenta-derived mesenchymal stem cells via heparin-grafted human fibroblast derived matrix
... of matrix-bound heparin After the decellularization process was done, we found out that cells completely lost their original morphologies after detergent and enzyme treatments ... See full document
9
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