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[PDF] Top 20 Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma

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Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma

Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma

... that follistatin-like protein 1 (FSTL1) was frequently down-regulated in metastatic ccRCC [19]; and the C allele of rs1259293 in the coding region of FSLT1 was associated with an increased ... See full document

15

miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma

miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma

... 230-kD protein, plays a key role in Huntington’s disease [23, ...and cell cycle regulation, among other processes [25, ...a tumor suppressor role in some types of cancer; ... See full document

14

Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

... KIBRA protein levels were signifi- cantly elevated by SP1 ...The role of the SP transcription factor family in different cancers has already been highlighted [37], and there is evidence that overactivation ... See full document

10

TIKI2 is upregulated and plays an oncogenic role in renal cell carcinoma

TIKI2 is upregulated and plays an oncogenic role in renal cell carcinoma

... The role of Wnt5a in different cancers is ...of tumor-initiating cells in breast cancer [21]. In the renal cell carcinoma TCGA dataset, more than 80% of specimens had lost one or two ... See full document

8

The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1

The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1

... total protein extracts were separated and transferred to polyvinylidene fluoride mem- ...for 1 hour at room tem- perature with an appropriate secondary antibody, followed by enhanced chemiluminescence ... See full document

10

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

... : renal cell carcinoma; ccRCC : clear cell renal cell carcinoma; mRCC : metastatic renal cell carcinoma; pRCC : papillary renal ... See full document

15

Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining

Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining

... The protein 4.1 family is a cytoskeletal protein char- acterized by the presence of the FERM domain (ezrin, radixin, and ...Just like other protein ...proteins plays a key role ... See full document

14

Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors

Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors

... candidate tumor suppressor genes, mesenchyme homeobox 2 (MEOX2) and sclerostin domain containing 1 (SOSTDC1) ...2 protein is a transcription factor that inhi- bits vascular endothelial ... See full document

9

Low expression level of ASK1-interacting protein-1 correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer

Low expression level of ASK1-interacting protein-1 correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer

... we divided the patients into the AIP high-expression group and low-expression group. The Kaplan–Meier survival curve was used to demonstrate the effect of AIP1 expres- sion on overall survival (OS) and disease-free ... See full document

9

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survival

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survival

... in protein lysis system con- taining RIPA (Wuhan Boster Biological Technology, ...of protein were measured using the bicinchoninic acid kit (Beyotime Institute of Biotechnology, Haimen, China) at 562 ...for ... See full document

14

Landscape of DNA Virus Associations across Human Malignant Cancers: Analysis of 3,775 Cases Using RNA-Seq

Landscape of DNA Virus Associations across Human Malignant Cancers: Analysis of 3,775 Cases Using RNA-Seq

... The ability to identify viral integration points within the host ge- nome using RNA-Seq provides a useful tool to study DNA viruses in cancer. For instance, our findings are consistent with other reports that have ... See full document

11

Overexpression of FoxM1 is associated with tumor progression in patients with clear cell renal cell carcinoma

Overexpression of FoxM1 is associated with tumor progression in patients with clear cell renal cell carcinoma

... the protein level, western blot was performed on those 39 paired ccRCC clinical ...the protein level of FoxM1 in tumor tis- sues was significantly higher than that in adjacent non- tumor ... See full document

13

Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms

Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms

... in renal papillary adenomas, suggesting that these chromosomal alterations may be involved in early neoplastic changes in pRCC [159, ...regulates cell survival [161, ... See full document

23

REVIEW The Impact of Tumor Eco-Evolution in Tumor Sampling

REVIEW The Impact of Tumor Eco-Evolution in Tumor Sampling

... that tumor sampling must be adapted to the tumor type to be efficient because tumor evolution and the spectrum of ITH are in fact very different, as reflected by the range of evolutionary trees ... See full document

19

Single-stage laparoscopic surgery for bilateral organ tumors using a transumbilical approach with a zigzag incision: a report of two cases

Single-stage laparoscopic surgery for bilateral organ tumors using a transumbilical approach with a zigzag incision: a report of two cases

... and renal vein were identified. One renal artery was blocked, but since the kidney did not shrink, another renal artery was identified and ...the renal vein was blocked and ... See full document

5

Identification of biomarkers of chromophobe renal cell carcinoma by weighted gene co-expression network analysis

Identification of biomarkers of chromophobe renal cell carcinoma by weighted gene co-expression network analysis

... Co‑expression network construction and module analysis Firstly, expression data profile of DEGs was tested by to check if they were the good samples and good genes. Afterwards, power value was screened out by WGCNA [14] ... See full document

12

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

... binding protein 3) tops both PTA (GCH = 79) and PTB (GPS = 95), while PMPCA (peptidase (mitochondrial processing) alpha, GPS = 74) tops the normal ...binding protein (G protein), q polypeptide) GPS = ... See full document

8

Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

... Despite these challenges, researchers have begun examin- ing the novel application of VEGFR TKIs in the treatment of non-clear cell RCC and have found evidence suggestive that VEGF TKIs have therapeutic ... See full document

5

Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

Original Article VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients

... VEGFR1 plays a role in tumour progression and binds VEGFA with at least 10-fold higher-affinity than does VEGFR2, VEGFR1 is expressed at low levels in RCC ... See full document

9

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

... be tumor-type specific or reflect an alternate mechanism by which the tumor microenvironment can influence T ...T cell metabolic dysfunction. Similarly, PD-1 was elevated on ccRCC CD8 TIL and ... See full document

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