[PDF] Top 20 Forkhead Box Transcription Factor Regulation and Lipid Accumulation by Hepatitis C Virus

... the regulation of ␤-oxidation of fatty ...neutral lipid staining indicated that HCV infection significantly increases lipid accumulation compared to that in the mock-infected ...increased ... See full document

... FIG. 3. Clustered point mutational analysis of the minimal large surface antigen promoter. (A) Sequence (subtype ayw) of the HBV large surface antigen promoter region from 2101 to 11 (13). Coordinates are derived from ... See full document

... deactivation through nuclear export, while inhibition of Akt leads to dephosphorylation, nuclear localization and activation of FOXO3a [64]. The cytosolic retention of FOXO3a prevents the transactivation of downstream ... See full document

... host factor, while CRABP2 greatly limits the hepatitis C virus (HCV) life ...the accumulation of lipid droplets (LDs), which enhanced the efficiency of the viral life ...the ... See full document

... resistance, lipid overload, elevated inflammatory cytokines and hyperglycemia? Whether FOXO1 plays similar roles like insulin resistance, in non-obese type 1 diabetic patients given that insulin deficiency is ... See full document

... gene transcription by the mutation of the Sp1-2 site cannot be simply due to suppression of the core promoter activity, as the mutation of the Sp1-1 site, which similarly suppressed the core promoter activity, did ... See full document

... that HCV does not impair Akt kinase activity but inhibits FoxO1 phosphorylation, while HCV infection reduces FoxA2 expression in the nucleus. In addition, an interaction of the HCV core protein may interrupt 14-3-3 and ... See full document

... The DNA-binding proteins which recognize the regulatory sequence elements of the hepatitis B virus (HBV) major surface antigen promoter were examined by gel retardation analysis, using n[r] ... See full document

... a hepatitis C virus (HCV) replicon suggests that the replicon does not elicit cellular innate antiviral ...regulatory factor 1 (IRF-1) was found to be significantly lower in cells harboring ... See full document

... rows). A quantitative analysis is presented in Fig. 5G. In con- trast, expression of constitutively active Arf1 (Arf1 Q71L- GFP) or Arf1 WT-GFP in FLRP1 (Fig. 5B and C) or plain Huh7 cells (Fig. 5E and F) ... See full document

... The chemotherapy based on docetaxel may be effective, because docetaxel was reported to lack cross-resistance with other anti-tumor drugs [4]. However, the resistance to docetaxel did occur and FOXM1 was shown to be a ... See full document

... 85 2.17 Biotiniylated oligo pull down Biotiniylated oligoucleotides were coupled to streptavidin beads in a solution containing 100µl PBS, 10µl FCS, 20µl of a 50% slurry of streptavidin-agarose beads (Sigma) and 1µl of ... See full document

... For instance, the development of resistance to antiestrogen therapy remains a clinically important problem. However, a major limitation in alternative approaches to treating or pre- venting antiestrogen resistance is ... See full document

... HESCs cells, no such effects were observed in Ishikawa or HEC-50B, suggesting FOXP1 is unlikely involved in the dysfunction in PTEN. Li et al. reported that stromal cells of endometrial carcinoma promoted proliferation ... See full document

... head box of FoxQ2 proteins from various phyla was used for this analysis, including sequences from the genome of the mollusc Lottia gigantea for which we identified four putative FoxQ2 genes by bidirectional blast ... See full document

... We hypothesize that miR-122 functions to augment HCV RNA accumulation and translation via association with a ribo- nucleoprotein complex similar or identical to the miRISC. Assembly of the miR-122/Ago2 complex ... See full document

... bona-fide transcription factors that recruit Smads to certain promoters through sequence-specific DNA ...various transcription factors that do not contact ...increase transcription through chromatin ... See full document

... islets in the two sections by overlay- ing the insulin immunostaining. We rendered Pdx1 immunoreactivity as mauve pseudocolor and scored cells in which we could unambiguously identify the nucleus on both sections for ... See full document

... Kunal Baxi,* ,1,2 Ata Ghavidel, †,1 Brandon Waddell,* Troy A. Harkness, † and Carlos E. de Carvalho* ,3 *Department of Biology and † Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, ... See full document

... CD36 transcription, we generated reporter con- structs with mutations on these two sites: UMpCD36-Luc [muta- tion for AP-2(U)], DMpCD36-Luc [mutation for AP-2(D)] and BMpCD36-Luc (double mutations for these two ... See full document