[PDF] Top 20 FORMULATION AND EVALUATION OF IN SITU GELLING OCULAR SYSTEM OF OFLOXACIN

... of Ofloxacin containing polymer solutions, 0.3% of Ofloxacin was added to the chitosan/Poloxamer solutions with continuous stirring until thoroughly ...in situ gel were filled in glass vials closed ... See full document

... Buffers salts were dissolved in 75 ml of distilled water. Hydroxypropyl methyl cellulose E15LV (HPMC E15LV) was added to the buffer solution and allowed to hydrate. Then carbopol 934 was sprinkled over the solution and ... See full document

... desirable ocular dosage form would be one that could be delivered in the form of drops, creates little or no problem for vision and needs to be dosed no more frequently than once or twice daily ...In situ ... See full document

... In situ formed gels are liquid which upon insertion, experience phase conversion in the cul de sac of eye to form a visco-elastic gel and these formed gels tender a reaction to environmental ...in situ gel ... See full document

... in-situ gelling systems were prepared and instilled as drops into the eye which undergo a sol-gel transition in the ...the formulation and evaluation of flurbiprofen ocular ... See full document

... In-situ gelling systems are viscous, mucoadhesive, polymer- based liquids that exhibit sol-to-gel phase transition with its favourable residence time on the ocular surface due to change in a specific ... See full document

... all formulation was neutral and slightly alkaline in ...in situ gel expose to acidic condition, free calcium ions will be released upon breakage of complexes between calcium chloride and sodium citrate, the ... See full document

... The gelling capacity of the formulations containing different ratio of carbopol 940 and HPMC (E50LV / E4M) was evaluated. It was performed by placing a drop of polymeric solution in vials containing 1 ml of ... See full document

... mucoadhesive system of promethazine HCl in order to improve the bioavailability, and decreases the side effects as the absorbed drug avoids liver’s first pass ... See full document

... Poloxamers, commercially available as Pluronic ® , are triblock copolymers composed of polyethylene oxide (PEO) units and polypropylene oxide (PPO) units (PEO/PPO/PEO). It exhibits reverse thermal gelation under certain ... See full document

... the formulation added to 10 ml volumet- ric flask with ...LC system comprising COSMIC- SIL 100 C 18 5 µm column at room temperature with mobile phase containing HPLC grade Acetonitrile and Water in the ... See full document

... Accelerated stability studies: The optimized niosomal dispersion which had higher entrapment efficiency was placed in vials and sealed with aluminium foil for a short term accelerated stability study at 25º±2º C/ 60±5% ... See full document

... delivery system with improved mechanical and mucoadhesive properties that could provide prolonged retention time for the treatment of ocular ...poor ocular bioavailability. In-situ gels are ... See full document

... was formulation and evaluation of in situ gelling system of ...in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the ...in ... See full document

... The studies were done by placing the formulation in a circular plastic cup. This was turn placed in an invertedUSP basket kept inside a beaker containing 200ml ofsimulated tearfluid pH 7.4, stirred at37º ±1ºin a ... See full document

... in situ gels have been investigated in an attempt to extend the ocular residence time of medications for topical application to the eye 44 (Swati and Suresh, ...In situ gel formation occurs due to ... See full document

... gel formulation was drawn up using a disposable syringe and placed carefully in the dissolution ...gelled formulation and maintaining the mild agitation conditions believed to exist in ...the ... See full document

... for ocular delivery of pilocarpine; using Poloxamer 407 as a positive thermosensitive ...xyloglucan formulation enhanced the miotic response to a degree similar to that of a 25 ...the system with the ... See full document

... in situ gelling system due to its low bioavailability following oral administration 7 ; their tablet form shows low bioavailability around 34±19% and their stability in the gastric ...in situ ... See full document

... Preparation of Floating in-situ Gel: In-situ gel formulation was prepared by simply dissolving a gel-forming polymer (sodium alginate) in distilled water. A crosslinking agent (calcium carbonate) was ... See full document