[PDF] Top 20 High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis
Has 10000 "High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis" found on our website. Below are the top 20 most common "High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis".
High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis
... with MLL- PTD had shorter event-free survival (EFS) and overall survivals (OS) [7, 8, ...how MLL- PTD contributes to AML and the genetic basis of MLL- PTD associated AML is still ...of ... See full document
9
Original Article Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation
... a high risk of progression to ...T-cell acute lymphoblas- tic leukemia (T-ALL) [12], plasma cell myeloma [13], and chronic lymphocytic leukemia ...I mutation confers prolifera- tion and ... See full document
7
<p><em>BCOR</em> mutation and <em>TLS-ERG</em> expression in acute myeloid leukemia with monoclonal immunoglobulinemia</p>
... fusion gene and BCOR gene mutation also ...fusion gene is formed by the rearrangement of TLS and ERG genes on chromosomes 16 and ...TLS-ERG leukemia fusion protein inhibits E1A premRNA ... See full document
5
Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
... the mutation status of NPM1 and the pres- ence of the FLT3-ITD in the same ...as mutations give rise to heteroduplexes that form earlier melting prod- ucts allowing ready detection of mutations even ... See full document
5
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation
... CXXC5 gene encodes a transcriptional activator with a zinc-finger domain, and high expression in human acute myeloid leukemia (AML) cells is associated with adverse ...global ... See full document
18
<em>PIK3CA</em> gene mutation associated with poor prognosis of lung adenocarcinoma
... PIK3CA mutations (E542K, E545K, and E545D mutation in exon 9, H1047R and H1047L mutation in exon 20), samples were loaded, in triplicate, into 96-well reaction plates, using the AmoyDx™ PIK3CA Five ... See full document
6
Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion
... genes associated with the metabolic process were enriched in miR-99a overexpressed cells, such as ATP1B1, ATP5G1 and ...in leukemia cells may lead to the acquisition of LSC-like ...maintenance ... See full document
15
The frequency of NPM1 mutations in childhood acute myeloid leukemia
... NPM1 gene were present in 8% of AML cases in this ...NPM1 mutations have been detected, with types A, B and D being the most common ...’ mutation in one NPM1-mutated case. The majority of NPM1 ... See full document
5
Original Article High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia
... with acute myeloid leukemia ...with high expression of DUSP5P1 had higher percentage of blasts in bone marrow (BM) than those without high expression ...DUSP5P1 high expression ... See full document
8
Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
... As reported previously [1], the TCGA cohort consisted of 200 adult patients with various subtypes of de novo AML. To increase the statistical power of our analysis and encompass a broader cohort of de novo AML pa- ... See full document
10
Accumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer
... was associated with a higher risk for subsequent development of distant metastases in patients with TNBC, and this was independent of clinico- pathologic ... See full document
6
Clinical use of FLT3 inhibitors in acute myeloid leukemia
... AML with FLT3 mutation, especially FLT3-ITD, has a relatively high relapse rate. Although one could hypothesize that targeting FLT3 in the upfront treatment of FLT3-mutated AML may result in better outcome, ... See full document
12
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia
... AML: Acute myeloid leukemia; TNFRSF4: Tumor necrosis factor receptor super- family member 4; CD8+: CD8-positive; HDs: Healthy donors; MDS: Myelodys- plastic syndrome; EB: Excess blasts; DEGs: ... See full document
13
DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes
... mutated gene: it takes into consideration where the mutations are collectively found (pattern-based approach), what is the effect of mutations on protein products (protein-change approach), and what ... See full document
13
High expression of eIF3d is associated with poor prognosis in patients with gastric cancer
... GC is a highly heterogeneous disease with poor clinical outcomes. The traditional stage classification systems have limited capacity to predict the results of GC patients. More relevant studies should be ... See full document
6
DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia
... target gene via the methylation of upstream CPG islands. Gene mutation in DNA methyltransferase which alter en- zyme function have now been described in acute leukemia, Yamashita et ... See full document
5
High expression of COL10A1 is associated with poor prognosis in colorectal cancer
... The expression of COL10A1 in six cell lines – HCT116, Caco2, SW480, SW620, LoVo, and FHC – was detected by QPCR and Western blot assays. The results were accor- dant that COL10A1 was high expressed in SW480, SW620 ... See full document
11
Mitogen-activated protein kinase binding protein 1 ( MAPKBP1 is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia
... into high and low expression ...levels associated with EFS and OS in the presence of other known risk ...in gene-microRNA expression and DNA methylation ... See full document
11
An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
... independent gene expression datasets from two studies, one from The Cancer Genome Atlas (TCGA) [26] and two (GSE12417-GPL96 and GSE12417-GPL570) from the study of Metzeler et ...of gene expression profiles ... See full document
13
Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
... ITD mutations were detected by agarose gel electrophoresis of the PCR ...ITD mutation. TKD mutations were detected by electrophoresis of the amplified products following digestion with EcoRV (Thermo ... See full document
7
Related subjects