[PDF] Top 20 A fully human anti-CD47 blocking antibody with therapeutic potential for cancer
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A fully human anti-CD47 blocking antibody with therapeutic potential for cancer
... Physiologically, CD47 is a broadly expressed antigen, present on many different cell types in almost all tissues ...[2]. CD47 is involved in a number of cellular processes, including proliferation [3–5], ... See full document
11
Evaluation of a novel human IgG1 anti-claudin3 antibody that specifically recognizes its aberrantly localized antigen in ovarian cancer cells and that is suitable for selective drug delivery
... OSPC-2 cancer cell lines clearly demonstrated scattered focal claudin3 expression along the whole cell membrane, instead of the physiological distribution pattern of healthy cells in which the protein is strictly ... See full document
12
CD47 blocking immunotherapies stimulate macrophage mediated destruction of small cell lung cancer
... with CD47 blockade enhances phago- cytosis of SCLC. CD47-blocking therapies have been shown to enhance the response of macrophages to monoclonal antibod- ies (11), but no monoclonal antibodies are ... See full document
12
An anti-ErbB2 fully human antibody circumvents trastuzumab resistance
... valid therapeutic target [26, 27, 36, ...7F3, anti-ErbB2 antibodies specific for domain I, have been demonstrated to induce PCD, but the involving mechanisms are not yet elucidated ...breast cancer ... See full document
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Is CD47 an innate immune checkpoint for tumor evasion?
... exploit CD47 expression in order to evade immunological eradication, and its overexpression is clinically correlated with poor ...behind CD47-mediated immune evasion is that it can interact with signal ... See full document
7
ABT 874, a fully human monoclonal anti IL 12/IL 23 antibody for the potential treatment of autoimmune diseases
... diseases. Therapeutic approaches targeting p40 (eg, anti-IL-12/IL-23 p40 antibodies) can prevent the binding of IL-12 and IL-23 to IL-12Rβ1 and thus abrogate their proinflammatory effects ...a fully ... See full document
8
A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts
... The fully human CXCR4 mAb, MDX-1338, was recently shown to effectively block calcium flux and migration of cancer cells, induce apoptosis in various tumor cell lines in vitro and reduce tumor growth ... See full document
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Immunoreactivity of the fully humanized therapeutic antibody PankoMab-GEX™ is an independent prognostic marker for breast cancer patients
... mediates antibody- dependent cellular cytotoxicity (ADCC) [6], therefore being anticipated to potentially evolve as an excellent therapeutic ...proprietary human glyco- engineered production cell ... See full document
8
Interleukin-17 and type 17 helper T cells in cancer management and research
... Th17, blocking the IL-23 pathway is one of the possibilities to directly impact the IL-17 response and tumor ...the cancer of ...skin cancer, IL-23-transduced DC- based vaccine can lead to strong ... See full document
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The potential of deferasirox as a novel therapeutic modality in gastric cancer
... of human can- cers ...in cancer tissue compared with adja- cent normal tissue; moreover, NDRG1 expression has been shown to be inversely correlated with the metasta- sis of some cancers, such as prostate ... See full document
7
Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents
... a potential benefit from alemtuzumab (anti-CD52), anti-TNF antagonists (with the caveat that etanercept failed to provide benefits in a larger study), 14 mycophenolate mofetil, complement inhibitors, ... See full document
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Membrane Forces and Key Protein Determinants of Hematopoietic Cell Function: Lamins and Myosin-II in Hematopoiesis and CD47 in Immunotherapy of Cancer
... of CD47 expression without adverse effects to anucleated PB ...with CD47 knockdown tumors, growth of tumors displaying normal levels of CD47 was unaffected by antibody ...of antibody ... See full document
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CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis
... plus anti-CD47 treatment and also revealed the emergence of a distinct group of macrophages (that we termed “Phag MΦ” cluster) that are phenotypically dis- tinct from the resident macrophage clusters ...of ... See full document
22
Developing recombinant HPA 1a–specific antibodies with abrogated Fcγ receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia
... containing the human ITGB3 cDNA encoding either leucine or pro- line at position 33 (HPA-1a or -1b, respectively). Upon bone marrow recovery, the transplanted mice had a chimeric platelet population, containing ... See full document
11
Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier
... two potential B sites in this region, located between ⫺973 and ⫺962 (B 1), and ⫺ 765 and ⫺ 754 ( B 2) nucleotides upstream of the initiation codon, on the human alcam promoter (34, ... See full document
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Myeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome
... Myeloid cell leukemia-1 (Mcl-1) is encoded by the Mcl-1 gene. Alternative splicing of the gene leads to isoform 1 (longer gene product) and isoform 2 (shorter gene product) [1]. Isoform 1, an important pro-survival ... See full document
8
Evidence for Mixed Membrane Topology of the Newcastle Disease Virus Fusion Protein
... by antibody to CT ...of antibody to CT sequences on membrane fusion was ...of antibody on the fusion of RBC with Cos-7 cells expressing the HN and F ...if anti-Ftail antibody could ... See full document
13
A new approach to comparing anti-CD20 antibodies: importance of the lipid rafts in their lytic efficiency
... involves anti-CD20 monoclonal Abs (mAbs), which are directed against the CD20-expressing members of the B-cell lineage, from late pre-B-cells through mature ... See full document
11
Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer
... [20–23]. CD47/SIRPα-based therapies have been proven as an effective treatment for solid tumors and hematologic malignancies, with several clinical trials in- cluding CD47-blocking monoclonal ... See full document
11
Disease severity in K/BxN serum transfer induced arthritis is not affected by IL 33 deficiency
... On day 6 after induction of arthritis, serum IL-33 levels were similar in WT and ST2 KO mice (WT, mean: 310 ± 192 pg/ml, range < 1.61 to 1258 pg/ml; ST2KO, 447 ± 287 pg/ml, range < 1.61 to 2142 pg/ml) and ... See full document
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