[PDF] Top 20 Functional analysis of a simian virus 40 super T-antigen.
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Functional analysis of a simian virus 40 super T-antigen.
... We have not compared the properties of the super and large T-antigens in the maintenance of transformation, but noted that cells transformed by the super T-antigen templates and the C120[r] ... See full document
9
Enterocyte Proliferation and Intestinal Hyperplasia Induced by Simian Virus 40 T Antigen Require a Functional J Domain
... The DNA tumor virus simian virus 40 (SV40) encodes a dominant-acting oncoprotein, large T antigen (TAg). This pro- tein is sufficient to induce transformation in multiple mamma- ... See full document
9
Analysis of Simian Virus 40 Chromosome—T-Antigen Complexes: T-Antigen Is Preferentially Associated with Early Replicating DNA Intermediates
... 281-295 0022-538X/83/100281-15S02.00/0 Copyright © 1983, American Society for Microbiology Analysis of Simian Virus 40 Chromosome-T-Antigen Complexes: T-Antigen Is Preferentially Associa[r] ... See full document
15
Mutational Analysis of Simian Virus 40 T-Antigen Primosome Activities in Viral DNA Replication
... mutant T antigens were assayed for the ability to relieve the RPA-mediated inhibition of primer synthesis and elongation (12, ...pol-prim, T antigen, unlabeled ribo- and deoxyribonucleoside ... See full document
10
Simian virus 40 large T antigen oligomers: analysis of electrophoresis in the absence of detergent.
... 711-716 0022-538X/85/120711-06$02.00/0 Copyright © 1985, American Society for Microbiology Simian Virus 40 Large T Antigen Oligomers: Analysis of Electrophoresis in the Absence of Deterg[r] ... See full document
6
Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix.
... Leakiness of the Lys-128 mutation for nuclear transport first was supported by our finding that Lys-128-mutant large T accumulated at nuclear substructures during the course of infection[r] ... See full document
9
Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.
... To establish such a system, we infected rat Flll cells with the retroviral large T expression vector pZIPTEX 7, which directs the expression of limiting amounts of large T and thus Cellu[r] ... See full document
9
Intestinal Dysplasia Induced by Simian Virus 40 T Antigen Is Independent of p53
... and T antigen-mouse monoclonal PAb419 (25); p53-rabbit poly- clonal FL-393 (sc-6243), p53-mouse monoclonal PAb240 (sc-99), MDM2-mouse monoclonal SMP14 (sc-965), p21-rabbit polyclonal M-19 (sc-471), and ... See full document
11
Induction of p53-Independent Apoptosis by Simian Virus 40 Small t Antigen
... Genetic analysis of the SV40 st death response. st is known to possess at least two functions, one attributed to its J domain and the second to its PP2A binding capacity (illustrated in the diagram in Fig. 1). We ... See full document
14
ATP-Dependent Simian Virus 40 T-Antigen–Hsc70 Complex Formation
... Simian virus 40 large T antigen is a multifunctional oncoprotein that is required for numerous viral functions and the induction of cellular ...transformation. T antigen ... See full document
10
Structure and synthesis of a simian virus 40 super T-antigen.
... DISCUSSION In productively infected permissive cells, the early region of SV40 DNA is transcribed into two mRNAs of 2.6 and 2.3 kb, which encode proteins of apparent molecular weights 17[r] ... See full document
11
Quantitative Analysis of the Binding of Simian Virus 40 Large T Antigen to DNA
... to these noncanonical sites being of an importance lesser than that of P1 to P4. We also observed that the affinity of the OBD for its target 5 ⬘ -GAGGC-3 ⬘ sequence is influenced to some extent by the nucleotide ... See full document
13
Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.
... small T antigens with the Ad5 E1B 19K amino acid se- quences was performed in order to identify sequences in SV40 large T or small t antigen which might be homologous to critical sequences in ... See full document
8
A functional simian virus 40 origin of replication is required for the generation of a super T antigen with a molecular weight of 100,000 in transformed mouse cells.
... 2 A Functional Simian Virus 40 Origin of Replication Is Required for the Generation of a Super T Antigen with a Molecular Weight of 100,000 in Transformed Mouse Cells Received 28 March 1[r] ... See full document
11
Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator.
... Positive and negative regulation of transcription in vitro: enhancer binding protein AP-2 is inhibited by SV40 T antigen.. Production of simian virus 40 large tumor antigen in bacteria: [r] ... See full document
6
Functional implications of oligomerization of simian virus 40 large T antigen during lytic virus infection.
... To determine the distribution of various forms of T antigen on the sucrose density gradients at a quantitative level, the corresponding gel bands were excised, eluted with 0.2 ml of 60% [r] ... See full document
7
Analysis of nonpermissivity in mouse cells overexpressing simian virus 40 T antigen.
... To verify that the Tag produced in the transformed mouse cells was functional for SV40 replication, we fused the different transformed lines to C6 monkey cells.. C6 cells are CV-1 monkey[r] ... See full document
7
Two separable functional domains of simian virus 40 large T antigen: carboxyl-terminal region of simian virus 40 large T antigen is required for efficient capsid protein synthesis.
... COLE',2* Department Genetics, Yale University School of Medicine, New Haven, Connecticut 065101; and Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 037562* [r] ... See full document
10
Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.
... Purified T antigens T ag were either not exposed - or exposed + to a heat shock for 10 min at 39°C, incubated in replication buffer containing plasmids with the SV40 origin of replicatio[r] ... See full document
8
Study of the Functional Activities Concomitantly Retained by the 115,000 Mr Super T Antigen, an Evolutionary Variant of Simian Virus 40 Large T Antigen Expressed in Transformed Rat Cells
... Transformation of secondary rat kidney cell cultures by recombinant DNA containing the super T antigen gene SVE 5 Kb and pSVsT or the large T antigen gene pSV1 and pSV40' DNA tested Plas[r] ... See full document
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