[PDF] Top 20 The functional CD8 T cell response to HIV becomes type specific in progressive disease
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The functional CD8 T cell response to HIV becomes type specific in progressive disease
... containing CD8 T cells directed against the virus are also present dur- ing chronic infection ...CTL response, which is highly focused toward a few epitopes during primary HIV infection, ... See full document
10
Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1
... although progressive increases approximately 7 years after seroconversion warranted subsequent antiretroviral therapy ...epitope-specific CD8 ⫹ T-cell popula- tions (B8-EI8 in subject ... See full document
10
Predicting the Impact of CD8+ T Cell Polyfunctionality on HIV Disease Progression
... of CD8 ⫹ T cells on virus ...and functional diversity of CD8 ⫹ T cells on HIV-1 disease progression, we extended a theoretical model on viral dynamics described previously ... See full document
12
Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice
... virus- specific CD8 ⴙ T cells are directed mainly against relatively conserved internal proteins, like nucleoprotein (NP), they are highly cross-reactive and afford protection against infection with ... See full document
11
Enhanced PD-1 Expression by T Cells in Cerebrospinal Fluid Does Not Reflect Functional Exhaustion during Chronic Human Immunodeficiency Virus Type 1 Infection
... with HIV-specific HLA class I tetramers (labeled with phycoerythrin or allophycocyanin; Beckman Coulter or NIH Tetramer Facility) at room temperature for 10 min, anti-PD-1 (Biolegend) at room temperature ... See full document
10
Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses
... antiviral CD8+ T cells in pediatric popula- ...Th1 type responses of a quality similar to those seen in adults, although emerging data from smaller stud- ies has led to a revision of these ...and ... See full document
11
Memory Phenotypes of HIV Specific CD8+ T Cell Responses Are Independent of Functional Activity as Defined by Cytokine Output
... the HIV-1 p24 clade A1 ancestral se- quence (Sigma-Genosys) were pooled in a matrix format using Deconvolute This! version ...CD3-AmCyan, CD8-APCCy7, CCR7-PeCy7, IFN γ -FITC, CD107a-PeCy5, MIP-1 β -PE, ... See full document
14
Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype
... the HIV-1 pandemic continues to climb, with a recent estimate of 33 million people living with HIV-1 ...from HIV-1 infection to the onset of AIDS varies markedly among subjects, with the average ... See full document
8
HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
... ELISPOT response pro- files of 245 natural controllers, compared to those of 96 progres- sors, against all known optimally defined epitopes, we obtained compelling evidence that a primary mechanism of control ... See full document
12
Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection
... in CD8 ⴙ T-cell responses between tissues, patient groups, and cell ...tional T-cell subsets, we performed statistical analysis using a multivariate, correlated-errors ... See full document
12
Functional impairment of Tax specific but not cytomegalovirus specific CD8+ T lymphocytes in a minor population of asymptomatic human T cell leukemia virus type 1 carriers
... as HIV and hepatitis C virus (HCV), virus-specific CTLs gradually lose their cytotoxic activity, the ability to proliferate and secrete a diverse profile of cytokines, ultimately leading to exhaustion, ... See full document
15
Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
... all HIV proteins computed in an independent subtype B infected cohort, in which there was good statistical power over a diverse array of HLA genotypes ...The specific amino acids representing the ... See full document
12
Marek’s disease in chickens: a review with focus on immunology
... hosts’ cell mediated immunity ...the disease is unknown and recombinant viruses lacking the cytoplasmic tail of ...wild type virus in both the resist- ant and susceptible chicken lines [52, ... See full document
19
Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load
... that HIV-1-specific T cells can target all HIV-1 proteins and that at least two-thirds of the expressed HIV-1 clade B sequence can be ...by HIV-1-in- fected persons at differing ... See full document
12
Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers
... ⴙ T cell responses are thought to play an important role during HIV infection, particularly in HIV controllers (HIC) in whom viral replication is spontaneously controlled without any ...that ... See full document
12
Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers
... of T-cell responses in mucosa and ...cific CD8 ⫹ T-cell responses in rectal mucosa and peripheral blood, suggesting broad dissemination of HIV-specific ... See full document
12
Investigation of the early HIV-1-specific CD8+ T cell response and the selection of escape viral variants.
... the functional status of the tetramer- binding T cells can also be ...particular response must be known for it to be ...virus-specific T cell response in a panel of ... See full document
548
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
... whether HIV-1-specific CD4 ⫹ T cells from controllers can directly exert the same effect as exoge- nous recombinant IL-21 on CD8 ⫹ T cells through IL-21 secre- ...of CD8 ⫹ ... See full document
9
Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... vitro, CD8 T cells from high Gag responders displayed an overall more polyfunctional cytokine profile upon stimulation with HIV peptide pools, with significantly more 2- and 3-function T cells ... See full document
10
Proliferation Capacity and Cytotoxic Activity Are Mediated by Functionally and Phenotypically Distinct Virus-Specific CD8 T Cells Defined by Interleukin-7Rα (CD127) and Perforin Expression
... virus-specific CD8 T cells prior stimulation with the cognate peptides and the proliferation capacity (fold increase) of virus-specific CD8 T cells after 7 days of in vitro ... See full document
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