[PDF] Top 20 Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains
Has 10000 "Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains" found on our website. Below are the top 20 most common "Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains".
Functional Dissection of CCR5 Coreceptor Function through the Use of CD4-Independent Simian Immunodeficiency Virus Strains
... Rh CCR5 levels evaluated, including levels barely detectable by FACS ...to CCR5 and a quantitative FACS assay, we estimated that less than an average of 400 copies of CCR5 were ex- pressed on the ... See full document
12
V3 Loop-Determined Coreceptor Preference Dictates the Dynamics of CD4+-T-Cell Loss in Simian-Human Immunodeficiency Virus-Infected Macaques
... and CD4 ⫹ -T-cell depletion patterns in macaques infected with CXCR4- and CCR5-tropic viruses have also been reported previously by others (30, 31), leading to the suggestion that target cell availability ... See full document
8
A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains
... of coreceptor tropism in viral pathogenicity is ...to use low levels of CCR5 (11, 44), and an increasing replica- tive fitness (45) and relative entry efficiency of the infecting virus (26, ... See full document
11
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.
... to use the same cofactor for viral ...with CCR5 is consistent with the role of this region in determining the tropism of envelope glycoproteins for CCR5 versus ...HIV-1 strains, as well as the ... See full document
9
Unique Pattern of Convergent Envelope Evolution in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques: Association with CD4-Independent Usage of CCR5
... of virus and infected cells ...the virus inoculum and variable replicative rates within the ...The use of molecularly cloned virus allows for the study of the role of virus evolution in ... See full document
14
CD4-Independent Infection of Two CD4−/CCR5−/CXCR4+ Pre-T-Cell Lines by Human and Simian Immunodeficiency Viruses
... Coreceptor use by HIV and SIV strains for entry into A3 and A5 ...the CD4 molecule but also on the expression of chemokine coreceptors, such as CXCR4 and ...(12G5), CCR5 (2D7), CXCR1 ... See full document
6
Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells
... on CD4 for entry, certain primate immunodeficiency viruses are able to infect cells independently of ...enter CD4-negative cells by using CXCR4 (12, 24, 60). More recently, a ... See full document
8
Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
... HIV-2 strains, CCR5 and/or CXCR4 are the principal coreceptors relevant to the replica- tion of these strains in ...tropic virus in PBMC was inhibited only by very high concentrations of ... See full document
18
Mucosal Transmission and Induction of Simian AIDS by CCR5-Specific Simian/Human Immunodeficiency Virus SHIVSF162P3
... human immunodeficiency virus ...preferential use of the CCR5 coreceptor for viral ...Although simian immunodeficiency virus (SIV) infection of macaques is a ... See full document
6
Coreceptor Specificity of Temporal Variants of Simian Immunodeficiency Virus Mne
... V1 through V4 of the envelope extracellular protein (Env SU) (3–5, 11, 20, 33, 42, ...with CD4, directly interact with the Env SU protein of HIV-1 to mediate entry into target cells provided an explanation ... See full document
6
Evidence for Common Structural Determinants of Human Immunodeficiency Virus Type 1 Coreceptor Activity Provided through Functional Analysis of CCR5/CXCR4 Chimeric Coreceptors
... viral strains, which included HXB2, HT92599, and UG93053, infected cells expressing chimeras containing any one of the four CXCR4 domains within the context of CCR5 (Tables 2 and ...molecule through ... See full document
12
Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV
... with simian immunodeficiency virus (SIV) exhibit high viral loads but do not de- velop disease, whereas infection of rhesus macaques (RM) causes CD4 ⴙ T cell loss and ...receptor CCR5 ... See full document
10
Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry.
... Reporter virus pseudotyped by M-tropic (JR-FL and ADA) Env-infected ...sus CCR5 but did not infect ...rhesus CCR5. Cells not expressing a transfected coreceptor were efficiently infected only ... See full document
10
Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus
... Although CD4 tropism is conserved, rare examples of CD4- independent viruses have been described that can utilize corecep- tors, either CCR5 or CXCR4, for entry in the absence of ...viruses, ... See full document
15
CD4-Independent, CCR5-Dependent Simian Immunodeficiency Virus Infection and Chemotaxis of Human Cells
... several strains of SIV used CD4 binding regions from African green monkeys, pigtail macaques, or humans indiscriminately when transfected into macaque-derived transformed CMMT cells, in spite of pre- dicted ... See full document
5
CD4-Independent Entry and Replication of Simian Immunodeficiency Virus in Primary Rhesus Macaque Astrocytes Are Regulated by the Transmembrane Protein
... either CCR5 or CXCR4 is a pivotal determinant of viral tropism; viruses that utilize CCR5 are generally macrophage tropic, those that use CXCR4 are lymphocyte tropic, and those that utilize both ... See full document
8
Simian Immunodeficiency Virus SIVrcm, a Unique CCR2-Tropic Virus, Selectively Depletes Memory CD4+ T Cells in Pigtailed Macaques through Expanded Coreceptor Usage In Vivo
... HIV-1, independent from strain tropism (50), suggesting a role for CCR4 in HIV-1 entry ...on CD4 ⫹ T cells in peripheral blood and the intestine is lower than the overall magnitude of CD4 ⫹ T-cell ... See full document
15
N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates
... vaccinia virus early-late promoter (pSC59 [25]). Purified vaccinia virus stocks were used at a multiplicity of infection of 10 ...encoding functional gp160, from a variety of HIV-1 primary isolates, ... See full document
10
Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates
... of CCR5 until cultured, whereas microglia have high levels of CCR5 soon after purification from brain tissue ...of CCR5 may explain why the CNS is infected early during the course of HIV infection, ... See full document
9
Decreased plasticity of coreceptor use by CD4 independent SIV Envs that emerge in vivo
... of CD4+ T cells prior to infection, in which CD4-independent virus variants arose in multiple animals in association with widespread macrophage in- ...to use CCR5 in conjunction ... See full document
12
Related subjects