[PDF] Top 20 Functional magnetic resonance: biomarkers of response in breast cancer

... of response to neoadjuvant chemo- therapy and the development of surrogate imaging ...ment response and establish parity of MRI exami- ations between ...assessing response in patients receiving ... See full document

... radiotherapy response rates can vary significantly, even between patients diagnosed with the same tumor ...on cancer biology. Biomarkers that provide prognostic or predictive information regarding a ... See full document

... The response correlated to the inhibition of Akt ser473 ...No response was seen in lumi- nal-like xenografts, which had lower baseline activity in the PI3K ...that response to PI3K inhibition was ... See full document

... a response assessment tool for NAT in breast cancer have chosen a variety of clinical outcome variables – including palpation, imaging-based size measurement change, and pathologic response – ... See full document

... Breast Cancer, Functional Magnetic Resonance Techniques, Diagnostic Imaging ...Introduction Breast cancer is the most common malignant tumor that threatens women’s ...of ... See full document

... = magnetic resonance ...of magnetic resonance imaging (MRI) of the ...improved cancer detection, diagnosis, and evaluation of response to therapy with breast MRI compared ... See full document

... tion of an intravenous Gd-based contrast agent) and diffu- sion-weighted MR imaging are used to assess the response to neoadjuvant chemotherapy (NAC). Even the weak contrast enhancement at the site of the primary ... See full document

... MRI provides powerful methods for investigating vascular changes associated with neoangiogenesis. These are already gaining currency in diagnosis, and are now being evaluated with regard to their ability to assess tumour ... See full document

... Ktrans value and more substantial drop in Ktrans and Kep at 2 weeks after therapy correlated with better clinical out- come or PFS. Our results support the hypothesis that after antiangiogenic therapy, the changes in ... See full document

... contrast-enhanced breast MRI [18] sug- gested that lesions in which contrast arrived rapidly (within approximately 2 min) and then washed out over the first 5 min probably represent cancer, whereas those ... See full document

... include breast cancer, lung cancer, colo-rectal cancer, melanoma, acute leukaemia and lymphoma (Carter, ...benefit. Response is assessed by change in size of measurable disease but this ... See full document

... with breast cancer is that the interpretation of emerging sclerotic areas in the skeleton may be a challenge, since these areas may represent disease progression due to blastic metastases or sclerosis by ... See full document

... However, the opinion of the Working Group, as expressed in the clinical practice guideline, is that these women should be screened using MRI. No changes were made. 4. One respondent pointed out that while the ... See full document

... Quantitative approaches to tCho Several diff erent quantitative approaches to tCho processing have been reported. Compared to qualitative approaches, quantitative results can be more objectively compared between diff erent ... See full document

... permeability, cancer cell dormancy, and response to radiation were not fully accounted for due to the limited immune response in this ...human cancer cell lines, yet it is resilient enough to ... See full document

... and breast cell proliferation [14, ...in cancer and breast cancer development [17] and prognosis [18], and elevated biomarkers of inflamma- tion are associated with reduced survival ... See full document

... of breast cancer (6) ...the breast can- cer and also for monitoring the response of neoadjuvant che- motherapy (7) ...to breast mass or to normal breast tissue. Also ... See full document

... Introduction Breast density has been identified as an important risk factor for developing breast ...getting breast cancer in women with high breast density is four to six times as large ... See full document

... Adjuvant Breast and Bowel Project (NSABP) B-18 and B-27 studies showed that NAC signifi - cantly increased the chance of having pathologically negative lymph ... See full document

... of cancer response to therapy and rapid evaluation of the efficacy of new anticancer drugs, the National Cancer Institute has recently established the Quantitative Imaging Network (QIN) to provide ... See full document