[PDF] Top 20 Functional and Structural Characterization of P[19] Rotavirus VP8* Interaction with Histo-blood Group Antigens

... The VP8* proteins did not bind to any HBGA tested in the study. P[14] VP8*, which binds to A-HBGA, was used as a positive ...4 Structural analysis of human P[19] Mc345 ...human ... See full document

... of rotavirus (RV) VP4 spike protein (VP8*) is implicated in binding to cellular receptors, thereby facilitating viral attachment and ...While VP8* of some animal RVs engage sialic acid, human RVs ... See full document

... IMPORTANCE Group/species C rotaviruses (RVCs), members of Reoviridae family, in- fect both humans and animals, but our knowledge about the host factors that con- trol host susceptibility and specificity is ...and ... See full document

... of interaction between human RVs and HBGAs in human saliva and ...of VP8* to synthetic oligosaccharides representing specific HBGAs and by blocking the binding by mono- clonal antibodies (MAbs) specific to ... See full document

... GII.12 P domain was shown to bind the B-type HBGA (B trisaccharide) by X-ray crystallography (Protein Data Bank ID 3R6K) ...GII.12 P domain B trisaccha- ride complex structure revealed that the electron ... See full document

... minimal structural binding motif, and the binding pocket was mainly negatively charged ...RHDVb P domain and H2-tri ...hydroxyl group was fixed in ␣ position in H2-tri ...the P dimer. (C) ... See full document

... In summary, we report the generation and characterization of a new panel of MAbs directed toward epitopes on the capsid of GII.4 norovirus, the predominant norovirus genotype. The VP1 domain specificity of each ... See full document

... the P domain is thought to contain the determinants for cell attachment and strain diver- ...The P domain can be further subdivided into P1 and P2 subdomains, and each subdomain likely has unique ...of ... See full document

... In the present retrospective study, we investigated whether the association between presence of HBGAs, being a secretor, and susceptibility to NV infection is specifi to the NV genotype or whether it can be generalized ... See full document

... a Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea b CRCINA, Inserm, Université d'Angers, Université de Nantes, Nantes, France ABSTRACT Some ... See full document

... The demonstration of the role of human HBGAs in TV repli- cation by the cell culture-based blocking experiments described in our study is highly significant, because such a study is impossible to carry out with human ... See full document

... nine tissues. This in turn suggests that variability in susceptibility to infection exists in the population. It is suspected that this might be comparable to the binding and susceptibility patterns identi- fied for RHDV ... See full document

... human histo-blood group antigens (HBGAs) and human milk oligosaccharides ...soluble antigens in humans, can be structurally alike, and can interact with equivalent residues at identi- ... See full document

... distal VP8* head of the spike protein ...the P[II] genogroup RVs, including the widely prevalent human RVs (P[8], P[4], and P[6]) and a rare P[19] ...porcine ... See full document

... ABH antigens were not detected on rabbit hepatocytes, a situation similar to that found in ...uses histo- blood group antigens as receptors on ... See full document

... obvious histo- blood group antigen binding pattern based on genetic identity seems to exist, although none of the sequences analyzed be- tween strains tested in this study were more than 75% identi- ... See full document

... to histo-blood group antigens present on gastrointestinal sections of secretor, but not nonsecretor, individuals ...this group also found that rNV VLPs bind to Le b ... See full document

... and rotavirus are the two most important causes of acute gastroenteritis in children ...and rotavirus recognize human histo-blood group antigens (HBGAs), and multiple binding ... See full document

... and Blood Centre of Zhejiang Province, 345 Wulin Road, Hangzhou, Zhejiang Province 310006, China 3 Received 15 April 2008/Accepted 6 August 2008 Norovirus (NoV) is a causative agent of acute ...to ... See full document

... 5.3 Conclusions The aim of the experiments described in this chapter was to study the potential function of the cytoplasmic extrusions seen in virus-infected cells. Through the use of impermeable Cell Tracker dyes for ... See full document