[PDF] Top 20 Fundamental mechanisms and biological applications of DNA mediated charge transport

... stack; DNA binding-proteins, intervening mismatches, and base lesions can serve to attenuate charge migration ...of DNA CT to stacking perturbations has led to its application in developing novel ... See full document

... through DNA is robust in these long DNA ...mismatched DNA that is ~20% of the length establishes a new point of reference for the sensitivity of DNA CT to minor ...the biological ... See full document

... proteins, DNA, and RNA, is vital for fundamental research as well as clinical ...with biological elements provide a natural foundation for such devices because of the inherent recognition ... See full document

... in DNA is DNA-mediated charge transport ...obases, DNA can serve as a bridge in long-range electron transfer (ET) ...photocleavage mechanisms, many of which result in the ... See full document

... towards mechanisms facilitating ...genetic mechanisms must have been integrated to take control over reproduction and evolution including life’s sometimes critical and destructive exposure to maximum ... See full document

... a DNA damage response helicase from ...by DNA damaging agents and cellular ...unwinds DNA that has single-stranded overhangs with a 5′ to 3′ polarity (31). DNA-RNA hybrid duplexes that form ... See full document

... in biological networks allows the utilization of the most graphical invariants in such a way that it is possible to identify secondary RNA (Ribonucleic acid) motifs ... See full document

... PLA-PEG mediated DNA complex, the cationic surface-active agent CTAB was used to modify the surface of PLA-PEG nanoparticles to make the surface take on positive ... See full document

... sulfation, DNA repair and apo- ...and biological methods led to neonatal lethality, abnormal lung development (similar to atelectasis), and dwarfism, associa ted with changes in cartilage ... See full document

... Besides glucose, other sugars and carbon sources have been explored as substrates for biological hydrogen production such as in dark or mixed acids fermentation. 9 For example, glycerol could be fermented by ... See full document

... the space charge and surface current. The conduction of the devices is also expected to be greatly influenced by the eventual presence of Ta nanoparticles embedded in the amorphous matrix and the choice of the ... See full document

... Interestingly, in the case of the GT mismatch, the electrochemical data clearly differ from the guanine oxidation data. GT shows a very high distal/proximal oxidation ratio, while the integrated cathodic charge is ... See full document

... transporters mediated renal and hepatic uptake of catalposide, which would be excreted via renal and biliary routes with or without coupling non-CYP mediated ...the transport of catalposide (Table ... See full document

... ening, angular deformations, bond rotational barriers, etc. that are included in the potential energy functions used to describe the molecules under study. Force field parametrization is usually performed in a way that ... See full document

... important biological processes, the function of BRCA1 in homologous recombination (HR) mediated repair is considered one of the major mechanisms contributing to its tumor suppression activity, and ... See full document

... wtFc transport in the rFcRn-GFP-MDCK cells (Figure 4A). The most likely explanation is that the addition of GFP to the C-terminus of the rFcRn cytoplasmic tail interferes with the binding of downstream effectors ... See full document

... for DNA damage detection, a bound enzyme transmits an electron to another protein bound to a distal location on the ...its DNA affinity, dissociates, and re-binds to a different region of the ...the ... See full document

... Aberrant DNA methylation patterns are a prominent hallmark of cancer cells (Hanahan and Weinberg ...three DNA methyltransferases (DNMTs) that have been shown to play a prominent role in cancer-specific ... See full document

... individual DNA helices at a defined distance from the electrodes and act as electrochemical reporters for ET through the intervening DNA ...through DNA. The first observation of ET through a densely ... See full document

... Novel materials such as anionic hydrogels respond to changes in pH and salt concentra- tion by reversibly swelling to many times their original volume [26]; filaments composed of such materials have potential application ... See full document