[PDF] Top 20 G protein coupled receptor kinase activity is increased in hypertension
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G protein coupled receptor kinase activity is increased in hypertension
... 13,000 g for 3 min (at room ...40 g/liter SDS, 100 g/liter 2-mercaptoethanol, and 0.25 g/liter bromophenol blue and sonicated for 15 ...1 g/liter Coomassie brilliant blue R-250, 50% ... See full document
8
G protein coupled and tyrosine kinase receptors: evidence that activation of the insulin like growth factor I receptor is required for thrombin induced mitogenesis of rat aortic smooth muscle cells
... is increased after balloon injury (5, 11), increases in vascular load (33), and induction of hypertension ...a G-protein coupled receptor and has a well-established role in ... See full document
8
The Epstein-Barr Virus BILF1 Gene Encodes a G Protein-Coupled Receptor That Inhibits Phosphorylation of RNA-Dependent Protein Kinase
... putative G protein-coupled receptor (GPCR) gene of EBV, BILF1, has hitherto escaped attention, yet BILF1-like genes are conserved among all known lymphocryptovirus species, suggesting that ... See full document
9
The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
... an increased risk for both CD and UC ...(AC)/cAMP/Protein Kinase A (PKA) pathway through Gs proteins [5, 18] and the Rho signalling path- way via G 12/13 [5, ... See full document
11
<p>G protein-coupled receptor kinase 2 regulating β2-adrenergic receptor signaling in M2-polarized macrophages contributes to hepatocellular carcinoma progression</p>
... double staining was performed. The paraf fi n-embedded tissue was sliced into 4 μ m sections, heated at 70°C, dewaxed with xylene and rehydrated with graded alcohol washes. Subsequently, a pressure cooker was used to per- ... See full document
15
Genetic association between <em>G protein-coupled receptor kinase 6/β-arrestin 2</em> and dopamine supersensitivity psychosis in schizophrenia
... 20% increased titration of the drug, or psychotic symptoms that were new to the patient or of greater severity, which occurred immediately after a decrease in drug dosage; or 3) TD: based on the information ... See full document
7
Regulation of G protein coupled receptor kinase subtypes in activated T lymphocytes Selective increase of beta adrenergic receptor kinase 1 and 2
... GRK activity (as measured by in vitro phosphorylation of rhodopsin) was found after 48 h (331 +/- 80% of controls) and 72 h (347 +/- 86% of controls) of exposure to ...of protein kinase C (PKC) by 10 ... See full document
9
The Role of G Protein-coupled Receptor Kinases in Cancer
... phosphodiesterase activity, and suggested that GRK1 was involved in GPCR desensitization ...GPCR receptor desensitization was greatly minimized ...β-adrenergic receptor, and subsequent recruitment of ... See full document
15
Regulation of bone formation and remodeling by G protein coupled receptor 48
... and activity of osteoclasts are increased in Gpr48-deficient mice, suggesting that Gpr48 has a negative effect on bone ...hormone receptor and its role in human disease (Mak et ... See full document
10
Drosophila G protein coupled receptor kinase 2 regulates cAMP dependent Hedgehog signaling
... G-protein-coupled receptor kinases (GRKs) play a conserved role in Hedgehog (Hh) ...the G-protein-coupled receptor (GPCR) protein ...pathway activity ... See full document
10
Anabolic effects of a G protein–coupled receptor kinase inhibitor expressed in osteoblasts
... G protein–coupled receptors (GPCRs) play a key role in regulating bone ...of receptor desensitization in osteoblasts. Receptor desensitization is largely mediated by direct ... See full document
12
Update on HER 2 as a target for cancer therapy: Alternative strategies for targeting the epidermal growth factor system in cancer
... over- activity of growth factor receptors ...to increased expression of EGF-like ligands, but it appears that this may only augment cell transformation by Ras itself ...particular ... See full document
5
Developmental and tumoral vascularization is regulated by G protein–coupled receptor kinase 2
... MLECs display an activated phenotype in a signaling context of ALK1-Smad5/8 downregulation and fail to assemble mature ves- sels supports that ALK1 could be also relevant in processes related to angiogenic resolution as ... See full document
18
Protein kinase C dependent activation of cytosolic phospholipase A2 and mitogen activated protein kinase by alpha 1 adrenergic receptors in Madin Darby canine kidney cells
... a G protein-coupled receptor, the alpha 1- adrenergic receptor, promotes cellular AA release via the activation of phospholipase A2 (PLA2) in Madin-Darby canine kidney (MDCK-D1) ...the ... See full document
10
The role of Feronia in regulating growth and development in Arabidopsis thaliana roots
... Prior to analysis by MS the protein is digested with an enzyme such as trypsin which cleaves the protein at Lysine (K) and Arginine (R) amino acids. These peptides are then separated by reverse phase C18 ... See full document
356
Expression of G protein-coupled receptor 56 is associated with tumor progression in non-small-cell lung carcinoma patients
... The human lung carcinoma cell lines A549, H520, and normal bronchial epithelial cell line human bronchial epithe- lial (HBE) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). All cells ... See full document
8
Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors
... binding. Although the binding of PKC to the 1 subunit residues 405–415 did not require the presence of S409 (Fig. 1 B,C), the possibility that phosphorylation of this residue may modulate PKC binding still remains. ... See full document
9
Role of Conformational Changes in G Protein-Coupled Receptor Activation
... (CB2) receptor is an attractive target for pain ...this receptor are less likely to cause unwanted psychoactive side ...sister receptor, human cannabinoid type 1 (CB1), using the GEnSeMBLE ... See full document
232
Recent insights from molecular dynamics simulations
... simulation studies and enhanced sampling methods used to study biased G protein-coupled receptor.. 18.[r] ... See full document
20
Functional characterisation of the Anopheles leucokinins and their cognate G protein coupled receptor
... neurohormone receptor-like-encoding sequences were also identified in a survey of the GPCR repertoire of the Anopheles genome (Hill et ...a receptor for Anopheles ... See full document
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