[PDF] Top 20 Gadd45a levels in human breast cancer are hormone receptor dependent

... modulating human breast cancer, thus far there have been no reports on whether the expression of Gadd45a is correlated with any clinicopathological ...of Gadd45a in human ... See full document

... We constructed a polytomous unconditional logistic regres- sion model for each risk factor variable, and performed case– case and case–control comparisons within the same model. For case–case comparisons, odds ratios ... See full document

... high levels of testosterone were primarily associated with increased risk of ER + /PR + and ER + /PR
cancers, as also found by the Nurses Health Study (8) and a cohort study that examined only ER + tumors ...the ... See full document

... in human breast cancer tissue are also in- versely correlated [41]; ERα seems to repress EGFR in breast cancer cells ...in breast cancer cells ... See full document

... In breast cancer lines, increased Src activity correlated with a shortened ERα t 1/2 ...ERα levels and estrogen-stimulated ERα loss was impaired by Src ...ERα levels in the BT-20 ... See full document

... Methods A recent roundtable discussion was convened by The Breast Cancer Therapy Expert Group (BCTEG) to review existing data on this topic and its impact on their current practice. Results Level 1 evidence ... See full document

... invasive breast carcinomas and their axillary lymph node metastases versus non-metastatic ...expression levels of GHR and NEDD9 proteins in both, epithelial and stromal components of axillary lymph node ... See full document

... et al. 1999). More studies are needed to decipher which, if any, of these phenotypes is associated with BRCA1’s func- tion as an ERα corepressor. Therefore, it will be necessary to perform detailed studies of the mammary ... See full document

... Metabolic and oxidative stress are a few of the other factors affecting endocrine resistance. The mechanisms are elucidated in detail below for each of these factors. Recent publications have demonstrated that ... See full document

... in breast cancer HR- negative cells might not be fully dependent on HIF activity, and that other transcription factors are potentially ...in breast cancer, respectively, for co-factors ... See full document

... tumor levels of urokinase-type plasminogen activator/plasminogen activator inhibitor type 1, denotes highly endocrine responsive ...and/or hormone receptor positivity, together with adverse ... See full document

... in breast cancer tumors, in T47-D cells, and that treatment with the cholesterol synthesis inhibitor RO reduced MPA- induced CD44 induction in these ...suppresses breast and prostate cancer ... See full document

... with breast cancer, this balanced A:B ratio is often altered, frequently due to apparent loss of PR-B ...of human tumors [9]. Therefore, loss of PR-B, as measured by protein levels in clinical ... See full document

... advanced breast cancer are widely dependent on the appropriate targeting of HRs and ...of breast cancer patients as a result of discordance between pri- mary and metastatic tumors ... See full document

... Abstract: Hormone therapy, rather than chemotherapy, is recommended for hormone-receptor positive (HR+), human epidermal receptor 2 negative (HER2−) advanced or metastatic breast ... See full document

... 4 human breast cancer cell lines after long-term estrogen deprivation ...ER levels and sensitivity to ...of hormone-independent ...a breast tumor protein signature of PI3K ... See full document

... 25. Wu H, Yang JM, Jin S, Zhang H, Hait WN: Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res 2006, 66:3015-3023. 26. Gonzalez-Angulo AM, Hennessy BT, Meric-Bernstam F, ... See full document

... this breast cancer ...(CD3+) levels in cases with high IDO1 in tumor, but not in ...high levels of T regulatory cell infiltration, as measured by FOXP3, similar to Soliman et ...negative ... See full document

... androgen receptor (AR) expression with tumor progression and disease-free survival (DFS) in breast cancer ...450 breast cancer patients. We found that breast cancers expressing ... See full document

... thyroid hormone responsive spot 14 homolog (Thrsp) and thyroid hormone receptor β1 (TRβ1) proteins in human breast cancer tissues and adjacent tissues, as well as its ... See full document