[PDF] Top 20 Gammaherpesvirus Lytic Gene Expression as Characterized by DNA Array
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Gammaherpesvirus Lytic Gene Expression as Characterized by DNA Array
... the array analysis confirms that both have the same transcriptional ...the array data strongly support this ...cDNA array for MHV-68 has been developed and used to provide an initial analysis of ... See full document
13
Development of a 950 gene DNA array for examining gene expression patterns in mouse testis
... well characterized genes expressed across many cell ...to array production is somewhat ...the expression of only those genes that are part of the transcrip- tome of the tissue of ...this gene ... See full document
10
Identification of Alternative Transcripts Encoding the Essential Murine Gammaherpesvirus Lytic Transactivator RTA
... by gene 50, is conserved among all characterized gamma- ...murine gammaherpesvirus 68 (MHV68) lacking both of the known gene 50 promoters (G50DblKo) revealed that this mutant retained the ... See full document
17
Tpl2/AP-1 Enhances Murine Gammaherpesvirus 68 Lytic Replication
... of DNA and adherent ...viral lytic gene M3 promoter ...virus lytic replication, because the expression of cellular kinases may directly affect the activity of the M3 promoter driving ... See full document
10
Murine Gammaherpesvirus 68 Has Evolved Gamma Interferon and Stat1-Repressible Promoters for the Lytic Switch Gene 50
... well- characterized model for Stat1-dependent gene activation that involves chromatin remodeling, the recruitment of transcrip- tional coactivators, cooperation with general and inducible transcription ... See full document
7
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
... are characterized as having two distinct life cycle phases: lytic replication and ...to lytic replication, are poorly ...Murine gammaherpesvirus 68 (MHV-68, or ␥ HV68) can establish de novo ... See full document
9
Amplification of JNK Signaling Is Necessary To Complete the Murine Gammaherpesvirus 68 Lytic Replication Cycle
... MHV68 DNA synthesis and possibly late gene expression remains to be deter- ...the lytic rep- lication cycle. Indeed, expression of dominant-negative c-Jun in- hibited Tpl2-related ORF50 ... See full document
10
Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68
... infection, lytic replica- tion or ...viral lytic gene expression, which ultimately leads to viral DNA replication and production of infectious ...Rta expression is suppressed, ... See full document
12
Amino Acids in the Basic Domain of Epstein-Barr Virus ZEBRA Protein Play Distinct Roles in DNA Binding, Activation of Early Lytic Gene Expression, and Promotion of Viral DNA Replication
... a DNA recognition domain enriched in basic amino acids, and a C- terminal dimerization domain, such as a “leucine zipper” or other hydrophobic coiled-coil structure (25, 38, ...The DNA recognition region of ... See full document
19
Kaposi's Sarcoma-Associated Herpesvirus ORF18 and ORF30 Are Essential for Late Gene Expression during Lytic Replication
... KSHV lytic replication system also allows us to examine the highly ordered pattern of gene expression fol- lowing ...of expression and fold change by displaying the results as percentages of ... See full document
14
Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages
... the lytic switch gene promoters in latently infected B-cell ...of lytic switch gene promoters have been identified, including ZEB1 and YY1 in EBV and the viral latency-associated nuclear ... See full document
9
Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice
... viral gene expression during lytic infection in vitro and in vivo and during latency in ...tate expression of transcripts from genes known to be ex- pressed during the lytic cycle in ... See full document
9
Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus
... viral DNA polymerase with DNA processivity activity and plays an essential role in virus genome replication ...PF-8 expression and function are RTA dependent in forming the repli- cation complex ... See full document
8
Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays
... each array ele- ment was subtracted, and the mean signal from the duplicate spots was calcu- ...viral gene and two for each cellular gene to assess hybridization ...duced expression values ... See full document
12
Relationship between Retroviral DNA Integration and Gene Expression
... (TK) gene promoter (which provides the cap site, TATA sequence, and two Sp1 ...sites). Expression of this gene is controlled by binding of the BPV E2 protein to an array of three binding sites ... See full document
8
Characterization of Gammaherpesvirus 68 Gene 50 Transcription
... the gene 50 region of the ␥HV68 genome ...to gene 50 are indicated, as are the locations of consensus poly(A) signals, which are indicated above (for those associated with the R strand of the viral genome) ... See full document
9
The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes
... 3 DNA synthesis (A), progeny production (B), viral protein expression (C), and viral mRNA levels (D) in wild-type, BDLF4 mutant, and revertant ...Viral DNA was prepared from HEK293 cells that carry ... See full document
5
The M10 Locus of Murine Gammaherpesvirus 68 Contributes to both the Lytic and the Latent Phases of Infection
... Plasmid construction. For this study, we constructed the following four dif- ferent versions of recombinant MHV-68. (i) The mutant virus ⌬M10⌬Tet was created by ET cloning (2, 34). For this purpose, the M10 region of ... See full document
10
Activation of Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Expression during Epithelial Differentiation
... KSHV DNA has been detected frequently in human saliva (6, 44), and when found, it occurs at a titer 2 to 3 log units higher than those at other anatomic sites ...support lytic replication of ...viral ... See full document
9
Antibody to a Lytic Cycle Viral Protein Decreases Gammaherpesvirus Latency in B-Cell-Deficient Mice
... of gammaherpesvirus latency and used the passive transfer of antibody to demonstrate that antibody can play a very signifi- cant role in limiting the number of cells that are latently in- fected, at least in ... See full document
9
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