[PDF] Top 20 Gastrointestinal stromal tumors: three decades of lessons

... show three different morphologic patterns; spindle cell type, epithelioid cell type and a third type, which has a mixed population of both spindle and epithelioid ... See full document

... In one patient with malignant ileal GIST, the tumor was fixed at the root of the mesentery and was infiltrating the pelvic organs, vessels and right ureter, and also had secondaries in the liver. It was locally ... See full document

... daily. Three (13%) and 14 (58%) out of 24 patients evaluable for response exhibited partial response and stable disease respectively, for a disease control rate of ... See full document

... therapy of imatinib and ipilimumab immuno- therapy was explored in metastatic or unresect- able solid tumors. Among the 26 patients three objective responses were seen, in one GIST (PR) and two melanoma ... See full document

... Results: A total of 20 patients with multiple GISTs were enrolled. There were 11 females and nine males with a median age of 59 years (range: 37 – 80 years). Of these cases, 16 were sporadic cases and four were ... See full document

... An important patient factor when considering the optimal duration of imatinib therapy is compliance with treatment and issues affecting adherence. Whatever the indication, imatinib is usually used for prolonged periods ... See full document

... Gastrointestinal stromal tumors (GISTs), although rare, are the most common submucosal tumors (SMTs) of the gastrointestinal (GI) tract ...the three key predictors of aggressive ... See full document

... of individuals currently alive who have been diagnosed with cancer at any point in time, irrespective of time since diagnosis, current treatment, or cure. Limited-duration prevalence represents the proportion of people ... See full document

... of tumors in SDH-deficient syn- dromes, including CT and CSS, can span over dozens of years ...Additionally, three males diagnosed with CT (one with a lesion “consistent with pulmonary chondroma”) were ... See full document

... GISTs in younger (under 40 years) patients are rare and not well characterized. Of the 10 GISTs in young adults, half occurred in the small bowel and had spindle cell morphology, and one case had lymph node metasta- sis. ... See full document

... Results: A total of 28 GIST patients were identified. The patients received preoperative IM treatment for a median length of 13.5 months, ranging from 5 to 37 months. PR and SD were observed in 24 (85.7%) and 4 (15.3%) ... See full document

... mesenchymal tumors located in re- gions of the gastrointestinal tract such as in the stomach (60–70 %), small intestine (20–25 %), colon and rectum (5 %), and esophagus (<5 %) ...“gastrointestinal ... See full document

... the tumors was classified into three categories, as follows: R0 (complete gross and microscopic resection), R1 (with microscopic residual lesions), and R2 resections (with retention of any gross residual ... See full document

... All patients had matching the eligibility criteria mentioned in our methodology. The diagnosis of Cd117- positive GIST was re-confirmed. All patients were subjected to surgery. The surgical approach was done for 7 ... See full document

... Pathology departments of Nuremberg Clinic center and the Erlangen University Hospital, Germany. Pathology reports have been thor- oughly evaluated for detailed gross descriptions of tumors. Only cases with ... See full document

... intestinal stromal tumor (GIST), high risk (tumor diameter 10 cm, mitotic 6/50 hpf), infiltrative tumor growth in colon muscularispropria, found no metastasis at 9 limfenode were found and the results of ... See full document

... Approximately 85% to 90% of all cases of gastrointestinal stromal tumors (GIST) are associated with gain-of-func- tion mutations in the gene KIT [1-4]. A further 5% to 10% of cases of GIST are ... See full document

... [3]. Gastrointestinal stromal tumors are specifically KIT (CD117) ...reported. Stromal tumors arising outside the gastrointestinal tract are extremely rare and are known as ... See full document

... Immunohistochemical staining demonstrated that tumor cells were positive for c-kit and CD34 expres- sion (Fig. 6c, d). The tumor cells were negative for the S-100 protein. The histological features and staining pattern ... See full document

... A diffuse large-cell lymphoma (DLCL) of B-cell origin is a lymphoid neoplasm with diverse clinical manifestations. These neoplasms present as masses and grow rapidly, and cause symptoms when they infiltrate tissues or ... See full document