Top PDF Generation of Antiviral Major Histocompatibility Complex Class I-Restricted T Cells in the Absence of CD8 Coreceptors
Generation of Antiviral Major Histocompatibility Complex Class I-Restricted T Cells in the Absence of CD8 Coreceptors
... MHC-I-restricted T cells is a likely consequence of inefficient thymic selection for MHC-I-restricted thymocytes in the ab- sence of CD8 ...the CD8 co- receptor, ...
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An Important Role for Major Histocompatibility Complex Class I-Restricted T Cells, and a Limited Role for Gamma Interferon, in Protection of Mice against Lethal Herpes Simplex Virus Infection
... MHC class I but that it may include induction of MHC class II, protection of neurons from apoptosis, and inhibition of HSV replication (5, 9, 10, 13, ...MHC class I expression in the ...
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Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells
... ef-specific CD8 ⫹ T lymphocytes (CD8TL) are associated with control of both simian immunodeficiency virus (SIV) (1–4) and human immunodeficiency virus type 1 (HIV-1) ...as T cell receptor-CD3 ...
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The Role of CD8+ T Cells and Major Histocompatibility Complex Class I Expression in the Central Nervous System of Mice Infected with Neurovirulent Sindbis Virus
... MHC class I mRNAs in neurons suggests that failure of NSV-infected neurons to express MHC class I pro- tein was due to a posttranscriptional block in protein expres- sion rather than a ...
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Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes.
... to major histocompatibility complex (MHC) class I molecules and are then transported to the surfaces of infected cells, where they are presented to virus- specific CD8 1 ...
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Major Histocompatibility Complex Class I Gene Controls the Generation of Gamma Interferon-Producing CD4+and CD8+ T Cells Important for Recovery from Friend Retrovirus-Induced Leukemia
... virus complex (FV) induces eryth- roleukemia and immunosuppression in immunocompetent adult mice, providing a good model for studying the immune response to retroviral ...
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Immune Modulator Adamantylamide Dipeptide Stimulates Efficient Major Histocompatibility Complex Class I-Restricted Responses in Mice
... of CD8 ⫹ IFN- ␥ -producing cells consistently increased in mice vaccinated with AdDP as the adjuvant after restimulation with the peptide encompassing the immunodominant MHC class ...
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Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation
... of CD8 ⫹ T cells in controlling HIV and simian immuno- deficiency virus (SIV) infections (12, 21, 25, 26), and, accord- ingly, research is now under way to develop vaccine modalities which elicit ...
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Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1.
... target cells expressing viral antigens were systematically identified by individually testing the effects of variations in responder cell concentration, culture medium composition, serum type, incubation time, ...
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The Virus-Specific and Allospecific Cytotoxic T-Lymphocyte Response to Lymphocytic Choriomeningitis Virus Is Modified in a Subpopulation of CD8+ T Cells Coexpressing the Inhibitory Major Histocompatibility Complex Class I Receptor Ly49G2
... with major histocompatibility (MHC) class I molecules ...entiated T-cell clones are endowed with cytolytic and gamma interferon-producing capacities, enabling them to manifest ...
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Transcriptionally Abundant Major Histocompatibility Complex Class I Alleles Are Fundamental to Nonhuman Primate Simian Immunodeficiency Virus-Specific CD8+ T Cell Responses
... that restricted SIV-specific CD8 ⫹ T cell responses were transcrip- tionally abundant by high-throughput ...SIV-specific CD8 ⫹ T cell responses, we characterized the peptide binding ...
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Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
... described CD8 1 cell-mediated protective immunity against lymphocytic choriomeningitis (LCM) virus in BALB/c mice following the injection of a portion of either the viral nucleoprotein (NP) or the glycoprotein ...
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Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire.
... A/HKx31. CD8 1 T cells were purified by nylon wool followed by panning on tissue culture flasks (Primaria; Becton Dickinson, Oxnard, ...Activated cells were purified on LSM Lympho- cyte ...
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Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice.
... splenic CD8 1 cells (Fig. 3A and B). Less than 1% of the spleen cells from noninfected KOD mice expressed CD8 ...splenic CD8 1 cells ...virus-specific, CD8 1 , L d ...
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Novel Role of CD8+ T Cells and Major Histocompatibility Complex Class I Genes in the Generation of Protective CD4+ Th1 Responses during Retrovirus Infection in Mice
... FV-erythroleukemia cells grown in the Cellmax artificial capillary cell culture system in Cellulosic MPS cartridges with a molecular mass cutoff of 30 kDa (Spectrum, Laguna Hills, ...AA41 cells were grown ...
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Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
... virus-specific T cells, among ...greatly restricted both in the amount and in the copy number of the viral genes ...forces antiviral CD4 ⫹ and CD8 ⫹ T cells directed ...
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Immunization with a Single Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Recognition Epitope of Herpes Simplex Virus Type 2 Confers Protective Immunity
... nition epitope, HSV glycoprotein B residues 498 to 505 (SSIEFARL) (gB498-505), fused to the adenovirus type 5 E3/19K endoplasmic reticulum insertion sequence (ES). Mucosal immunization of C57BL/6 mice with this ...
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Putative Immunodominant Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype
... T cells in this patient (peptides 1, 14, 43, 45, 46, 77, and 78 shown in ...1), restricted to either HLA-A2 or other HLA ...by CD8 ⫹ T cells ...
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Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells
... the CD8 ⫹ T-cell responses mounted after SIV ...SIV-specific CD8 ⫹ T-cell response has been previ- ously identified and published, and the restriction of this re- sponse was not determined ...
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Two Major Histocompatibility Complex Class I-Restricted Epitopes of the Borna Disease Virus p10 Protein Identified by Cytotoxic T Lymphocytes Induced by DNA-Based Immunization
... (anti-rat CD8; Serotec, Raleigh, ...the cells were fixed on ice for 20 min with 250 l of BD Cytofix/Cytoperm (BD Bioscience, San Jose, ...permeabilized cells were stained with fluorescein ...
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