[PDF] Top 20 Genome wide association scan for chronic periodontitis implicates novel locus

... a genome-wide analysis. Chronic periodontitis has a prevalence of over 47% in the United States based on NHANES data [22], and in general lower sample sizes are necessary to study a common ... See full document

... The genetic variations in the adiponectin gene can affect the circulating adiponectin level and stimulation of adiponectin receptor that may affect the activity of adiponectin. This has been associated with insulin ... See full document

... conducted genome-wide admixture mapping scans in 1,737 African Americans from the Atherosclerosis Risk in Communities (ARIC) ...admixture association with either CRAE (genome-wide score ... See full document

... SNPs were assayed using Sequenom technology for the AGP samples at three centers, namely Gulbenkian, Mt. Sinai, and Oxford: DNA from 1,629 families representing numerous recruiting sites was genotyped for 54 SNPs. SNPs ... See full document

... 4q24 association marked by rs71597109 ...this locus have been associated with systemic lupus erythematosus risk 12 ...19p13.3 association marked by rs7254272 ... See full document

... The EpiPen package provides a convenient utility for con- verting, comparing, and interpreting epistatic models with more flexibility than existing software. The included util- ities are useful for performing simulation ... See full document

... Genome-wide association studies (GWAS) have conven- tionally focused on identifying associations between indi- vidual single-nucleotide polymorphisms (SNPs) and the phenotype, but there is growing ... See full document

... Genome wide analysis of the association between the TB EBV and each SNP was performed after correcting for the underlying population ...The genome wide Manhattan plot displaying the ... See full document

... an association study utilizing 6,912 SNPs obtained using a low-density bovine SNPchip, and 39,611 imputed SNPs along the bovine ...genome. Association was performed for 16 traits related to economic ... See full document

... Affymetrix Genome-Wide Human SNP ...of genome-wide association between genotyped and imputed markers and aldosterone to renin ratios was performed on the remaining 1786 subjects, using ... See full document

... the genome began with the quantitative genetic analysis of gene-expression profiles, referred to as genetical genomics [69] or expression QTL (eQTL) mapping ...Treating genome-wide gene-expression ... See full document

... located on chromosome 5q33-34, which has been implicated in AMD [52]. rs6847164 re- sides within PDE5A, a gene located on chromosome 4q27. According to the databases of NCBI and Entrez, PDE5A is involved in the ... See full document

... Genomic DNA was extracted from peripheral blood leukocytes of AD patients and healthy individuals using the Wizard genomic DNA purification kit (Cat. #A1125, Promega, USA).Genotyping of INPP5D (rs35349669) and APOE ... See full document

... the association between the IL28B gene and response, these related studies provide incontrovertible genetic evidence for a role of the IL28B gene in spontaneous and treatment-related recovery from HCV ... See full document

... In contrast to the suspected periodontal pathogens noted above, C. ochracea was significantly more prevalent and showed significantly more positive sites per patient in the con- trol group than in the ... See full document

... susceptibility locus associating with the risk of TB ...non-MHC locus can be identified in an infectious Table 3 Distribution of genotypes in cases and controls and their risks with pulmonary ... See full document

... hypospadias risk-associated SNPs for replication on the basis of the following three criteria: (i) P < 1 × 10 − 4 in the association test (370 SNPs met this criterion), (ii) linkage disequilibrium (LD) r 2 ... See full document

... significant association with the fowl typhoid spanned the AKT1 ...SAL1 locus were not identified by the genome-wide scan for layers from the second outbreak, pathway analysis revealed ... See full document

... this locus are known to affect mammographic density [27–30] which is associated with both ER-positive and ER-negative breast cancer ...this locus including ARMT1, CCDC170 , and RMND1 may also be candidates ... See full document

... Previous HLA analyses, including those reported from large collaborative GWAS efforts (representing most of our follow-up sample), have been equivocal, which likely reflects known heterogeneity at the locus and ... See full document