[PDF] Top 20 Genomic profiling reveals mutational landscape in parathyroid carcinomas

... Recurrently mutated genes. The landscape of somatic mutations and copy number alterations is shown in Figures 2 and 3, respectively. Assessing protein-altering somatic mutations at the gene level, there are 92 ... See full document

... Early genomic profiling studies employing targeted sequencing of selected cancer-related genes aided in the identification of some prevalent mutations in LCNECs 15–17 ...all genomic alterations in LCNECs and ... See full document

... the landscape of TMB across the spectrum of human cancer based on data from comprehensive genomic profiling (CGP) of more than 100,000 patient tumors of diverse ... See full document

... Effective treatment options for advanced salivary gland tumors are lacking. To better understand these tumors, we report their genomic landscape. We studied the molecular aberrations in 117 patients with ... See full document

... Patient with metastatic cancer TUMOR BIOPSY MOLECULAR PROFILING Histology Control CGH Transcriptomic Aberrations % of cancer and normal cells Mutational aberrations. & M[r] ... See full document

... Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin Lymphoma comprising of greater than 30% of adult non-Hodgkin Lymphomas. DLBCL represents a diverse set of lymphomas, defined as diffuse ... See full document

... of genomic features and pharmacological ...ilar genomic traits and the most effective drugs are then listed for any single cell lines, thus missing the direct asso- ciation between a specific genomic ... See full document

... Breast cancer is the most common cancer affecting women worldwide, and in Thailand [1]. It is a complex and heterogeneous disease with varied morphological manifestations, molecu- lar features, behaviors, and responses ... See full document

... 3. Kozarewa I, Rosa-Rosa JM, Wardell CP, et al. A Modified Method for Whole Exome Resequencing from Minimal Amounts of Starting DNA. PLOS ONE. 2012;7(3):e32617. 4. Mikulasova A, Wardell CP, Murison A, et al. The spectrum ... See full document

... element insertion into the intronic sequences located spotting, at least on the C57BL/6J background (Hodg- between exons 3 and 4. As a result of this insertion, Mitf kinson et al. 1993). However, unlike with Tietz syn- ... See full document

... large genomic size (~350 kbp) and complexity (61 exons), the absence of any obvious mutational hotspots or recurrent mutations, and the wide spectrum of mutation types ...of mutational clustering and ... See full document

... F IG . 1.—Genomic overview of transcription of Z. tritici isolate IPO323. Each vertical line on the outermost thick track reports the location of a Z. tritici gene on the indicated core (blue) or accessory ... See full document

... the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL ...greater ... See full document

... the mutational profile and major MM cytogenetic abnormalities (Figure ...the mutational profile and the recurrent IgH translocations was identified (Figure ... See full document

... Bignell GR, Bolli N, Borg A, Borresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjord JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M, Jager N, ... See full document

... Although human epidermal growth factor receptors have been implicated in MOT progression through amp- lification and overexpression of ERBB2 (HER2), activat- ing mutations in other family members have not been previously ... See full document

... A better solution is likely to be a web-based interactive intelligent decision support system that is dynamic and regularly updated at both global and regional scales. The key point is that increased availability of ... See full document

... hypermethylated CDKL2 and ZNF397OS , and significant CNV gains were observed for hypomethylated KCNQ2 and PTPRN2 , suggesting potential important role of CNVs in regulation these genes ’ function. Figure S4. Distribution ... See full document

... (hazard ratios [HR] of 3.17 and 17.11, respectively; P 0.001) and in models corrected for relevant clinic pathologic pa- rameters (HR 2.87 and 12.42, respectively; P 0.023). Simi- larly, candidates in GSE63885 [22] ... See full document

... PCR amplification and deletion analysis. To amplify the regions of differences in the genome of M. tuberculosis clinical isolates, PCR primers for all the 14 RDs and TbD1 regions were designed according to the method of ... See full document