[PDF] Top 20 Gut–kidney crosstalk in septic acute kidney injury

... of acute kidney injury (AKI) in the intensive care unit ...(ICU). Septic AKI is a complex and multifactorial process that is incompletely ...further gut injury and breakdown in ... See full document

... with septic AKI, our review of the availa- ble evidence would suggest that ATN might be uncommon in this ...structural injury to this ...of septic AKI – also challenge the view that ischemia and ... See full document

... with increased risk of AKI 18 and mortality. 213-215 Adequate antimicrobial dosage adjustment for patients with severe sepsis associated AKI is challenging, especially in RRT-treated patients. In addition to alteration ... See full document

... content was expressed as MDA content per g protein, determined by the Bradford assay. TNF-α and IL-6 were determined by ELISA (DY510, DY506; R&D Systems, Minneapolis, MN). Immunohistochemical analysis After fixation ... See full document

... We should consider some limitations of this study. We only included patients from a single medical center. Regarding AKI definition, we only have baseline serum creatinine of 55 % of patients who developed AKI, for the ... See full document

... The bacterial species most often involved in Gram‐negative sepsis and septic shock are Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa [13]. The lysis of these organisms results in the release of ... See full document

... of kidney function, 10 penkid might be a “connecting peptide” in the precur- sor only, presumably without a function in the blood ...the kidney and the ...Upon acute kidney dysfunc- tion, ... See full document

... Early Acute Kidney injury (PEAK) ...or septic shock on each ICU day was recorded in the database (Table ...characteristics, Acute Physiology And Chronic Health Evaluation (APACHE) II ... See full document

... comparable septic insult and indistinguishable systemic hemodynamic response, only those pigs that developed AKI had a very early increase in the plasma levels of TNF- a and ...the kidney injury ... See full document

... of septic AKI in humans should not be exclusively viewed in the context of distributive shock- associated ischemia, but rather also within the context of a dysregulated and ill-defined inflammatory response to ... See full document

... filtration rate: Q F , 300 mL/h; and dialysate flow rate: Q D , 1000 mL/h) over 24 h. The mean 24-h clearance values for TNF-α, IL-6, IL-8, and HMGB-1 were 11.4, 20.9, 17.8, and 11.2 mL/min, respectively. The cytokine- ... See full document

... attenuated kidney injury after the ...injured kidney, this level of DAO activity might not be sufficient to protect against tubular ...the gut to the circulation might compensate for decreased ... See full document

... hepatic injury after severe renal ...against gut-derived ...by gut-derived endotoxin than the kidney. However, the role of gut-derived endotoxin in renal IR-induced liver injury ... See full document

... of acute kidney injury in the patient with acute brain injury The majority of patients with acute traumatic brain in- jury are young and have normal renal ...and acute ... See full document

... in septic shock (> 65 mmHg) and cardiac output was com- parable to that of ICU patients without septic ...with septic shock with AKI than in those with no AKI or mild AKI, suggesting that renal ... See full document

... C, heart rate of more than 90 beats/min, hyperventila- tion evidenced by a respiratory rate of more than 20 breaths/min or a partial pressure of arterial carbon dioxide of less than 32 mmHg, and a white blood cell count ... See full document

... in septic shock mainly af- fected by dysfunction of the renal vascular bed rather than systemic hypotension and renal ...of septic AKI is lower WBC and platelet ... See full document

... pooled analysis evaluating 28-day mortality, HVHF was associated with a small but nonsignificant trend toward benefit compared with SVHF. The use of an extracorporeal therapy to augment in- flammatory mediator clearance ... See full document

... Haemodynamics in sepsis patients: The hemodynamic hallmark of sepsis is generalized arterial vasodilatation with an associated decrease in systemic vascular resistance. Arterial under filling due to arterial ... See full document

... Acute Kidney Injury (AKI) is one of the most challenging problems faced by clinicians in the tropics owing to its fast-changing ...with septic abortions while late peak is associated with ... See full document