[PDF] Top 20 H2-Receptor Antagonistic Activity of Some N-Substituted 2-Methyl Imidazoles
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H2-Receptor Antagonistic Activity of Some N-Substituted 2-Methyl Imidazoles
... scheme, N-substituted 2-Methyl Imidazole derivatives of the type 1 (Scheme:1) have been synthesized by treating 2-methyl imidazole and various para substituted phenacyl ... See full document
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Molecular docking study on the interaction between 2-substituted-4,5-difuryl Imidazoles with different Protein Target for antileishmanial activity
... The Lamarckian Genetic Algorithm was used to explore the best conformational space for the ligand with a 50 docking runs for each ligand. The maximum numbers of generation and evaluation were set at 27000 and 2500000, ... See full document
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Design, synthesis and biological activity of novel substituted 2 Aryl sulfonyl methyl tryptamines as potential 5 HT6 Receptor ligands
... intermediate 5a. These derivatives 5a-t were oxidized and the crude product purified by flash column chromatography to obtain compounds 6 as free bases. The latter were converted to HCl salt to obtain the targeted ... See full document
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SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW [1-BENZYL-2- PHENYL-SUBSTITUTED]-1H-5, 6-SUBSTITUTED-BENZO (d) IMIDAZOLES DERIVATIVES
... on some 1-[(thio carbamoyl hydrazine carbonyl)methyl]-2-phenyl-1H- benzimidazole,N-[(2-phenylbenzimidazol-1-yl-methyl)-[1,3,4]-thiadiazole-2-yl arylamines & their in ... See full document
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW SUBSTITUTED IMIDAZOLES
... 10. Patrice Vanelle, Jacobine Meuche, José Maldonado, Michel P Crozetb, Florence Delmas and Pierre Timon-David: Functional derivatives of 5-benzo[1,3]dioxol-5-yl-1-methyl- 1H-imidazole-2- carbaldehyde and ... See full document
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3D QSAR OF N SUBSTITUTED IMIDAZOLES AS ANTIFUNGAL AGENTS
... www.wjpr.net Vol 4, Issue 1, 2015. 1688 analogues. This green contour matched with hydrophobic groups in the pharmacophoric model developed by authors of the original paper. A large green contours found to surround the ... See full document
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Effect of Histamine and Its Methyl Derivatives on Cyclic AMP Metabolism in Gastric Mucosa and Its Blockade by an H2 Receptor Antagonist
... effect. N-methyl-N¢-(2-[5-methylimidazole-4-yl- methylthio]-ethyl) -thiourea (metiamide), a new H2 receptor inhibitor, selectively blocked the stimulation of adenylate cyclase by ... See full document
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ANTI-ULCER ACTIVITY OF 1-SUBSTITUTED IMIDAZOLES AGAINST GASTRIC ULCERS IN RATS
... that imidazoles are very much effective on Histamine receptors which are found principally in the parietal ...antiulcer activity of some newly synthesized 1-substituted imidazoles ... See full document
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SYNTHESIS OF SOME NEW 2 (N SUBSTITUTED) 3H PHTHALAZIN 1, 4 DIONE DERIVATIVES FOR THEIR ANTIHYPERTENSIVE ACTIVITY
... antihypertensive activity for 2-N-substituted pthalazine 1,4-dione ...derivatives. 2-N-substituted pthalazine 1,4-dione derivatives were synthesized by taking the ... See full document
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME SUBSTITUTED 2 ((1H INDOL 4 YL)OXY) N' BENZYLIDENEACETOHYDRAZIDE
... antifungal activity of the synthesized derivatives was done in comparison with Ofloxacin and Fluconazole as standard to reveal the potency of synthesized ...good activity against all the tested bacteria and ... See full document
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A conventional synthesis and characterization of so me novel substituted N {(2 methyl/mercapto 1 H benzo[ d ]imidazol 1 yl)methyl}substituted benzenamine, N {(2 methyl/mercapto 1 H benzo[ d ]imidazol 1 yl)(substituted phenyl)methyl}substituted benzenamine as potential cytotoxic agents
... of N-{(2-Methyl/Mercapto-1H-benzo[d]imidazol-1-yl)methyl}substituted benzenamine (1a-1c) & (3a-3c), ... See full document
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ANTIMICROBIAL ACTIVITY OF SOME 2-SUBSTITUTED BENZOTHIAZOLES SYNTHESIZED FROM 2-AMINOTHIOPHENOL
... Bio-isosteric relations constitute one of the most familiar tools in medicinal chemistry. The Sulphur and Nitrogen are considered to be isosteric pair and activity is retained in the compound by such a ... See full document
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Synthesis and Antimicrobial Activity of 2 (4 ((4 substituted phenoxy)methyl) 1H 1,2,3 triazol 1 yl) N arylacetamides
... (Scheme 2) ...with 2 N hydrochloric acid, followed by saturated sodium bicarbonate solution and finally with brine ...get 2-bromo-N-arylacetamides ... See full document
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Synthesis of Substituted Imidazoles via a Multi-Component Condensation Catalyzed by p-toluene Sulfonic Acid, PTSA
... Imidazoles enjoy an outstanding status due to their biological importance. PTSA, a non toxic and inexpensive catalyst is optimized for the synthesis of tri- and tetra- substituted imidazoles. ... See full document
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Synthesis and antitubercular activity of some novel N-methyl triazolone derivatives
... The N-methyl Triazolone is prepared by methylation of triazole-5-one which was further converted in to the respective acids by reacting with p-amino benzoic acid (Mannich base ...Anti-tubercular ... See full document
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Synthesis and anti microbial activity of novel mannich bases containing 2 phenoxy 1, 3, 2 dioxa phospholanes and Indole systems
... from 2-propanol and petroleum ether (60-80 0 C) solvent mixture to afford (4R, 5R) - N’4, N’5-bis-(2-oxo indolin-3-ylidene) – 2 – phenoxy - 1, 3, 2 - Dioxaphospholane-4, ... See full document
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Synthesis, characterization and pharmacological studies of some novel 2 N (aryl substituted) 4 methyl 6 phenylpyrimidine 5 carboxylic acids
... ethyl-6-methyl-2-oxo-4-phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate (1) was prepared by the reaction of benzaldehyde, ethyl acetoacetate, urea and a catalytic amount of ...1, 2, 3, ... See full document
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Crystal structures and Hirshfeld surfaces of differently substituted (E) N′ benzylidene N methyl 2 (thiophen 2 yl)acetohydrazides
... symmetry. We may speculate that these C—H groupings have been ‘activated’ (made more acidic) by being adjacent to the electron-withdrawing cyanide group (Pedireddi & Desiraju, 1992). The chains are cross-linked by ... See full document
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Regulation of density of functional presynaptic terminals by local energy supply
... Electron microscopy and immunofluorescence in vivo Mature Sprague–Dawley rats (male, 16 months old) were fed Magnesium L-Threonate (MgT; dosage as pre- viously described) (Magceutics Inc.) in their water for 8 months ... See full document
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SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME 2-SUBSTITUTED BENZIMIDAZOLES
... Antifungal activity of synthesized compound was tested against Candida albicans and Aspergillus niger. The MIC of the synthesized compounds was determined by broth macrodilution using sterile glass test tubes ... See full document
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