[PDF] Top 20 Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1α
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Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1α
... HCV infection suppresses GLUT2 transcription via downregulation of HNF-1␣ expression at both transcriptional and translational levels ...a C-terminal disul- fide bond ... See full document
9
Hepatocyte nuclear factor 1α and β control terminal differentiation and cell fate commitment in the gut epithelium
... Hes1 expression contributes to the maintenance of the proliferative crypt compartment of the small intestine by inhibiting the transcription of two cyclin-dependent kinase inhibitors (Riccio et ...the ... See full document
10
Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... HNF6 reduces the steady-state levels of HBV RNA via post- transcriptional mechanisms. The pgRNA of HBV serves as the template for reverse transcription and is critical for viral replica- tion. The transcription of ... See full document
11
Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus
... ␣ downregulation resulted in rearrangement of cytosolic lipid droplets (LDs), as evidenced by the aggregation of large LDs and distorted cytosolic ...␣-regulated factor involved in VLDL secre- tion, was ... See full document
16
Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation
... HBV-induced downregulation of HNF4α could enhance the proliferation of hepatoma cells and increase their tumorigenicity both in vitro and in ...HBV expression on liver tumor progression in animal ... See full document
19
The hepatitis E virus ORF3 protein regulates the expression of liver-specific genes by modulating localization of hepatocyte nuclear factor 4
... transcription factor is expressed mainly in the liver and plays important roles in nutrient transport and metabolism, blood maintenance, immune function, liver differentiation and expression of growth ... See full document
10
Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins
... The hepatitis B virus (HBV) core promoter regulates the transcription of two related RNA products named precore RNA and core ...HBV infection converts a nuclear receptor binding site in the ... See full document
7
Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3.
... restricted expression of the ...simplex virus thymidine kinase promoter ...of expression from the HBV promoters differentially in transient-transfection analysis, it seems likely that these ... See full document
8
Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy
... ACKNOWLEDGMENTS We are grateful to C. M. Rice (Rockefeller University, New York, NY) for providing us Huh-7.5 cells and pFL-J6/JFH1. We thank Y. Kozaki and Y. Sakahara for secretarial work. This research was ... See full document
14
Hepatocyte nuclear factor 1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription
... transcription factor PPARg promotes metabolic adaptations of lipogenesis and aerobic glycolysis under the control of Akt2 activity, but the role of PPARg in liver tumorigenesis is ...with hepatocyte ... See full document
17
Hepatitis C Virus Infection Upregulates CD55 Expression on the Hepatocyte Surface and Promotes Association with Virus Particles
... that hepatitis C virus (HCV) infection of hepatocytes or HCV core protein expression in transfected hepatocytes upregulated CD55 expression at the mRNA and protein ...or ... See full document
9
Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice
... cellular gene expression rather than direct effects on viral gene expression can explain the HNF1␣- mediated alterations in HBV ...the nuclear CCC HBV DNA, these results suggest that ... See full document
12
Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... transcription factor on HBV transcription and replication observed in cell culture can be recapitulated in vivo in the HBV transgenic mouse model ...reporter gene analysis (9, ...growth factor ... See full document
7
Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees
... ISG expression during HCV infection may help resolve the cell types involved as ...cytokine gene expression as a function of viral ...of expression changes in ISGs (ISG12 [ F ] and ... See full document
14
Expression of Regeneration and Tolerance Factor Correlates Directly with Human Immunodeficiency Virus Infection and Inversely with Hepatitis C Virus Infection
... HCV ⫹ individuals, but not in those seropositive for HCV alone. This result indicates that there may be a correlation between RTF expression and HIV-associated immune activa- tion. Interestingly, as illustrated in ... See full document
6
Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
... reduce transcriptional activity in vitro, lower glucose- stimulated insulin secretion in vivo, and increase the risk of type 2 diabetes especially in the overweighs and the elders. As we know, HNF-1α is ... See full document
5
Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... inhibited HBV replication but to a considerably lesser extent than from a template that encoded the HBeAg polypeptide. This analysis indicated that HBeAg contributes to the inhibi- tion of viral replication in mouse ... See full document
10
Hepatitis C Virus Infection
... Patients should meet certain criteria for thera- py. These include medical aspects of the disease, as well as its associated social considerations. The decision to treat must evaluate overall health, age, likelihood of ... See full document
9
Hepatitis C Virus Infection
... In 1994, the first outbreak of HCV infection asso- ciated with a licensed intravenous immunoglobulin was reported in the United States. 16,17 According to the US Public Health Service, this outbreak involved ... See full document
7
The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... Though these proteins share similar DNA-binding charac- teristics, their activation domains are distinct. For the same reason, homodimers of HNF-1α and HNF-1β trigger the transcription, while heterodimers of these ... See full document
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