[PDF] Top 20 Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase
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Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase
... an NS5B CRE duplication ...the C- terminal membrane segment of human cytochrome b5 (Cb5), a prototype tail-anchored protein (8), did not yield any viable clones ...a structural interaction element in ... See full document
5
The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A
... HCV RNA replication has not yet been determined, it is known that replication takes place in two ...HCV RNA-dependent RNA polymerase NS5B, an enzyme that has been ... See full document
12
Mutagenesis Analysis of the rGTP-Specific Binding Site of Hepatitis C Virus RNA-Dependent RNA Polymerase
... HCV RNA replication. Purified recombinant NS5B lacks template specificity in vitro, as it is able to catalyze RNA polymerization on both HCV-specific RNA and nonviral RNA ... See full document
11
Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
... positive-stranded RNA viruses and may be used to define a new class of enzymes that direct de novo ...two conserved residues make a -hairpin in NS5B, (one of two -hairpins in an oth- erwise ... See full document
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Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase
... (RNA-RNA, RNA-DNA, or DNA-DNA) without exhibiting substrate specificity in vitro (19, 20, ...helicase requires a 3 ⬘ -end single-stranded overhang in order for initia- tion of duplex unwinding ... See full document
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Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.
... fundamental structural and mechanistic similar- ities which are reflected by distinct sequence motifs (for a review, see reference ...HCV NS5B with RTs and viral RdRps as a basis for site- directed ... See full document
13
Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
... hydrophobic domain at the C terminus of NS5B and mapping of a conserved LLLL motif in this domain which significantly affects the solubility on ...truncated NS5B ... See full document
6
Selection of RNA Aptamers That Are Specific and High-Affinity Ligands of the Hepatitis C Virus RNA-Dependent RNA Polymerase
... torial RNA library in which the randomized sequence is con- tained in a constant background that imposes structural con- straints on the ...process requires only four to five cycles of enrichment ... See full document
9
The Hepatitis C Virus RNA-Dependent RNA Polymerase Membrane Insertion Sequence Is a Transmembrane Segment
... The hepatitis C virus (HCV) RNA-dependent RNA poly- merase (RdRp), represented by nonstructural protein 5B (NS5B), is believed to form a membrane-associated ... See full document
6
Hepatitis C Virus RNA Replication and Virus Particle Assembly Require Specific Dimerization of the NS4A Protein Transmembrane Domain
... 2 Replication and infectivity of HCV subgenomic replicon in ...HCV replication in ...encephalomyocarditis virus. (B) Design of replication and released infectivity ...(C) ... See full document
15
De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus
... the virus (6, 50, ...most conserved regions of the viral genome and plays a pivotal role in the initiation of translation of the viral polyprotein (6, 12, 13, ...into structural (core, E1, and E2) ... See full document
13
Membrane Association of the RNA-Dependent RNA Polymerase Is Essential for Hepatitis C Virus RNA Replication
... HCV NS5B is one of the few RdRps with an experimentally determined transmembrane domain ...house virus protein A (25, ...positive-strand RNA viruses occurs by interactions with other ... See full document
7
Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation
... When C-terminal domain mutants were tested in a sub- genomic replicon system, the respective RNAs showed marked decreases in translation and replication despite having increased RdRp activity in ... See full document
12
3D–QSAR analysis of 5–cyano–6–aryl–2–thiouracil as inhibitors of Hepatitis C viral NS5B RNA–dependent RNA polymerase
... as Hepatitis C viral NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp) inhibitors have been subjected for QSAR analysis using VLife MDS ...at C–6 position of ... See full document
8
Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase
... a virus family regrouping animal (mainly vesivirus and lagovirus but also norovirus and sapovirus) and human pathogenic (exclusively norovirus [NV] and SV) ...the replication strategies of these important ... See full document
14
Mechanism of De Novo Initiation by the Hepatitis C Virus RNA-Dependent RNA Polymerase: Role of Divalent Metals
... dengue virus replicase was suggested to exist in at least two conformational states that are in dynamic equilibrium ...for RNA synthesis in vitro (22). The FIG. 10. Comparison of RNA synthesis by ⌬51 ... See full document
13
Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II
... influenza virus polymerase complex or with the indi- vidual polymerase ...influenza virus polymerase subunits copuri- fied with TAP-CTD, suggesting that the trimeric complex was the ... See full document
7
3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
... pin within the thumb domain of the NS5B polymerase posi- tions the terminal sequences of the genome so as to initiate de novo transcription from the 3⬘ terminal ...novo RNA synthesis at ... See full document
12
Analysis of astrovirus serotype 1 RNA, identification of the viral RNA-dependent RNA polymerase motif, and expression of a viral structural protein.
... A region of 600 nt encoding the RDRP motif from three of the other available human astrovirus serotypes demonstrated a high degree of homology at the nucleotide and amino acid levels Fig[r] ... See full document
7
Interaction with a Ubiquitin-Like Protein Enhances the Ubiquitination and Degradation of Hepatitis C Virus RNA-Dependent RNA Polymerase
... of hepatitis C virus (HCV) RNA-dependent RNA polymerase (NS5B), we searched for cellular proteins interacting with NS5B protein by yeast two-hybrid screening ... See full document
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