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[PDF] Top 20 Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo

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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo

Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo

... FIG. 4. RNase protection analysis mapping the transcription initi- ation sites of the precore (PC) and pregenomic (C) transcripts from the livers of HBV transgenic mice. (A) Groups of three mice of each sex and genotype ... See full document

7

In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators

In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators

... C/EBP, hepatocyte nuclear factors 3 and 4, retinoid X receptor ␣ (RXR␣), and peroxisome proliferator-activated receptor ␣ (PPAR␣), and ubiquitous transcription factors including Sp1 and RFX1 have been shown ... See full document

10

The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival

The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival

... HBV replication did not, in turn, determine whether HBV replication or expression of HBV proteins affected the PI3K/AKT pathway (43, ...ex vivo hepatocyte systems likely represent more ... See full document

14

Cytokine-Sensitive Replication of Hepatitis B Virus in Immortalized Mouse Hepatocyte Cultures

Cytokine-Sensitive Replication of Hepatitis B Virus in Immortalized Mouse Hepatocyte Cultures

... mouse hepatocyte cell culture system that replicates HBV and is sensitive to the antiviral activities of cytokines, reflecting the behavior of the virus and the cytokines in vivo (3, 4, 9, 11, 12, ... See full document

8

The Enhancer I Core Region Contributes to the Replication Level of Hepatitis B Virus In Vivo and In Vitro

The Enhancer I Core Region Contributes to the Replication Level of Hepatitis B Virus In Vivo and In Vitro

... Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular ...the virus results in the selection of escape mutants and viral ...HBV replication-competent ... See full document

10

Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice

Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice

... viral replication interme- diates in HBV transgenic ...of replication interme- diates in the liver compared with HNF1␣-expressing HBV transgenic mice ...viral replication intermediates ...detectable ... See full document

12

Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication

Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication

... Chronic hepatitis B virus (HBV) infection is associated with a 100-fold-higher risk of developing hepatocellular carcinoma (HCC) ...a nuclear localization signal, it has been proposed that HBx ... See full document

7

Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus

Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus

... FIG 2 HNF4 ␣ is not required for HCV entry or RNA replication. (A) Huh7.5.1 cells were transfected with HNF4 ␣ siRNA (siHNF4 ␣ ), CD81 siRNA (siCD81), or a scrambled siRNA (siCtrl), followed by inoculation of ... See full document

16

Novel Type of Hepatitis B Virus Mutation: Replacement Mutation Involving a Hepatocyte Nuclear Factor 1 Binding Site Tandem Repeat in Chronic Hepatitis B Virus Genotype E

Novel Type of Hepatitis B Virus Mutation: Replacement Mutation Involving a Hepatocyte Nuclear Factor 1 Binding Site Tandem Repeat in Chronic Hepatitis B Virus Genotype E

... chronic hepatitis patients who were treated with IFN ...of hepatitis, as shown in the fulminant-hepatitis case with a single HNF1 site insertion ...viral replication and progression of liver ... See full document

7

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells

... transcription factor NF- ␬ B to con- trol the expression of inflammatory cytokine genes in many types of ...␬ B, and transcription factor IRF3, all of which are required for activation of IFN- ... See full document

12

Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes

Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes

... human hepatitis B virus (HBV), the woodchuck hepatitis virus (WHV), and the duck hepatitis B virus ...necrosis factor alpha (TNF-a), induced in the liver by ... See full document

7

Alpha/Beta Interferon Differentially Modulates the Clearance of Cytoplasmic Encapsidated Replication Intermediates and Nuclear Covalently Closed Circular Hepatitis B Virus (HBV) DNA from the Livers of Hepatocyte Nuclear Factor 1α-Null HBV Transgenic Mice

Alpha/Beta Interferon Differentially Modulates the Clearance of Cytoplasmic Encapsidated Replication Intermediates and Nuclear Covalently Closed Circular Hepatitis B Virus (HBV) DNA from the Livers of Hepatocyte Nuclear Factor 1α-Null HBV Transgenic Mice

... viral replication was inhibited with nucleoside analogs, and it was estimated that the half-life of HBV CCC DNA was approximately 3 days ...woodchuck hepatitis virus and duck hepatitis ... See full document

8

Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β

Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β

... viral replication has been investi- gated in mouse ...tocyte nuclear factor 3/forkhead transcription factor family (19, 21, ...viral replication, whereas the carboxyl-ter- minal ... See full document

10

Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6

Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6

... V01460.1) replication-competent plasmid ...HNF6 inhibits HBV gene expression and replication in hepatoma ...(A, B, D, and E) or 96 h posttransfection (C and ...RI, replication ... See full document

11

Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx

Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx

... and nuclear proteins such as SMC4 and ...A, B, and C were coprecipitated with HA-JMJD5 in 293T cells expressing these proteins, the interaction between JMJD5 and HBx of genotype B was weaker than ... See full document

13

Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation

Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation

... a nuclear factor which exists abundantly in the liver and controls the transcription of many genes involved in hepatocyte function [9, ...that inhibits tumor progress in HCC [10, 13, ...HBV ... See full document

19

Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins

Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins

... As shown in Fig. 7B, the two mutations that abolished the expression of the X protein from the wild-type genome did not affect the transcription of the precore RNA and the core RNA in Huh7 cells. This was consistent with ... See full document

7

Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1α

Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1α

... We along with other groups previously reported that HCV NS5A protein is involved in mitochondrial reactive oxygen species (ROS) production (11, 13, 38). Mitochondrial ROS generation is known to induce the autophagy ... See full document

9

Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene.

Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene.

... The chloramphenicol acetyltransferase CAT-containing plasmids that were used in this study were i pTWU54, in which the cat gene is under the control of the 353-bp HindIll-HincIl DNA regi[r] ... See full document

6

The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.

The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.

... limits. We also demonstrated, for the first time, that the pre- core-mediated dominant negative effect occurred without re- ducing the steady-state level of HBV RNA, suggesting that precore gene products do not interfere ... See full document

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